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Query: FZR1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FZR1 0 0.187 0.740 -0.470

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FZR1 Ubiquitylation K263 0.187 _GFVQIWDAAAGKK(gl)_
FZR1 Ubiquitylation K135 -0.177 _GLFTYSLSTK(gl)R_

Background Information for FZR1:


Pubmed-FZR1 »
Uniprot-FZR1 »
Biogrid-FZR1 »
ProteomicsDB-FZR1 »

Tumorportal-FZR1 »
COSMIC-FZR1 »
GenomeRNAi-FZR1 »
Genecards-FZR1


Protein-protein Interactions for FZR1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANAPC15 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANAPC16 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANAPC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BUB1B Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC16 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC23 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC26 Cat. description Hein, Mann, Cell 2015
Category members IP bait NAA11 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANAPC13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C16orf87 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDCA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTGF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CUEDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FZR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HCCS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SRP68 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FZR1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52


Protein complexes (CORUM database) featuring FZR1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring FZR1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.38
Category members GO Category GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.35
Category members GO Category GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.26
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Database 2.59
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0005680 anaphase-promoting complex Database 0.63
Category members Pathway Pathway_220 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 0 0.6
Category members Pathway Pathway_985 PID_AURORA_A_PATHWAY 0 0.34
Category members GO Category GO:0070979 protein K11-linked ubiquitination Database 0.25
Category members Pathway Pathway_1028 PID_PLK1_PATHWAY 0 0.16
Category members GO Category GO:0070306 lens fiber cell differentiation Database 0.13
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0031572 G2 DNA damage checkpoint Database 0
Category members GO Category GO:0040020 regulation of meiosis Database 0
Category members GO Category GO:0045732 positive regulation of protein catabolic process Database 0
Category members GO Category GO:0051488 activation of anaphase-promoting complex activity Database 0


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