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Query: PAK1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PAK1 0 1.345 1.190 -0.630

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PAK1 Phosphorylation T212 0.312 _SVIEPLPVT(ph)PTR_
PAK1 Phosphorylation S223 1.033 0.153 _DVATSPIS(ph)PTENNTTPPDALTR_
PAK1 Phosphorylation S174 -1.439 -0.597 _AVSETPAVPPVS(ph)EDEDDDDDDATPPPVIAPRPEHTK_
PAK1 Phosphorylation S220 -0.916 -0.774 _DVATS(ph)PISPTENNTTPPDALTR_
PAK1 Phosphorylation T219 -0.560 -0.962 _DVAT(ph)SPISPTENNTT(ph)PPDALTR_
PAK1 Phosphorylation T230 -1.418 -1.502 _DVATSPISPTENNTT(ph)PPDALTR_
PAK1 Phosphorylation T225 -1.278 _DVATSPISPT(ph)ENNTTPPDALTR_

Background Information for PAK1:


Pubmed-PAK1 »
Uniprot-PAK1 »
Biogrid-PAK1 »
ProteomicsDB-PAK1 »

Tumorportal-PAK1 »
COSMIC-PAK1 »
GenomeRNAi-PAK1 »
Genecards-PAK1


Protein-protein Interactions for PAK1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARHGEF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARHGEF7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FSD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ICAM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPXN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OR2K2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHOJ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SETX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SOX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TAS2R41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PAK1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members CRIB_dom IPR000095 0.13
Category members WASP_C IPR011026 0.08
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring PAK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PAK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_1147 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION 0 1.89
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members Pathway Pathway_962 BIOCARTA_FAS_PATHWAY 0 1.75
Category members GO Category GO:0030426 growth cone Database 1.61
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_669 PID_RAC1_PATHWAY 0 0.68
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0014704 intercalated disc Database 0.64
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members Pathway Pathway_1078 PID_S1P_S1P2_PATHWAY 0 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_963 BIOCARTA_TNFR1_PATHWAY 0 0.44
Category members Pathway Pathway_1076 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 0 0.44
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_838 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES 0 0.35
Category members Pathway Pathway_985 PID_AURORA_A_PATHWAY 0 0.34
Category members GO Category GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis Database 0.33
Category members GO Category GO:0032956 regulation of actin cytoskeleton organization Database 0.33
Category members GO Category GO:0001726 ruffle Database 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0030018 Z disc Database 0.32
Category members Pathway Pathway_548 BIOCARTA_RAC1_PATHWAY 0 0.3
Category members GO Category GO:0031532 actin cytoskeleton reorganization Database 0.29
Category members Pathway Pathway_510 SIG_CHEMOTAXIS 0 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0030425 dendrite Database 0.26
Category members Pathway Pathway_560 REACTOME_CELL_CELL_COMMUNICATION 0 0.25
Category members GO Category GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway Database 0.25
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_188 KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 0 0.24
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0030424 axon Database 0.23
Category members Pathway Pathway_701 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES 0 0.22
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members GO Category GO:0006887 exocytosis Database 0.2
Category members Pathway Pathway_573 REACTOME_TCR_SIGNALING 0 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_615 BIOCARTA_CDC42RAC_PATHWAY 0 0.18
Category members Pathway Pathway_1036 REACTOME_CD28_DEPENDENT_VAV1_PATHWAY 0 0.18
Category members Pathway Pathway_165 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0 0.18
Category members Pathway Pathway_1028 PID_PLK1_PATHWAY 0 0.16
Category members Pathway Pathway_629 PID_EPHB_FWD_PATHWAY 0 0.14
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_1041 BIOCARTA_AGR_PATHWAY 0 0.13
Category members Pathway Pathway_546 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY 0 0.13
Category members Pathway Pathway_622 REACTOME_CD28_CO_STIMULATION 0 0.13
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members Pathway Pathway_499 KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 0 0.1
Category members GO Category GO:0004702 receptor signaling protein serine/threonine kinase activity Database 0.1
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0007015 actin filament organization Database 0.08
Category members Pathway Pathway_647 BIOCARTA_NKCELLS_PATHWAY 0 0.06
Category members Pathway Pathway_620 REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 0 0.06
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members Pathway Pathway_1137 REACTOME_DSCAM_INTERACTIONS 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_511 PID_EPHA2_FWD_PATHWAY 0 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_653 BIOCARTA_MET_PATHWAY 0 0.04
Category members Pathway Pathway_434 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 0 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members GO Category GO:0033138 positive regulation of peptidyl-serine phosphorylation Database 0.03
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members GO Category GO:0005518 collagen binding Database 0.02
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0031941 filamentous actin Database 0.01
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1031 REACTOME_SIGNALING_BY_ROBO_RECEPTOR 0 0
Category members Pathway Pathway_1039 PID_P38_ALPHA_BETA_PATHWAY 0 0
Category members Pathway Pathway_1148 REACTOME_ACTIVATION_OF_RAC 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_387 ST_T_CELL_SIGNAL_TRANSDUCTION 0 0
Category members Pathway Pathway_524 BIOCARTA_FMLP_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_589 BIOCARTA_RACCYCD_PATHWAY 0 0
Category members Pathway Pathway_640 PID_NETRIN_PATHWAY 0 0
Category members Pathway Pathway_646 KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 0 0
Category members Pathway Pathway_693 BIOCARTA_PYK2_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_998 BIOCARTA_AT1R_PATHWAY 0 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0007528 neuromuscular junction development Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0016358 dendrite development Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0031295 T cell costimulation Database 0
Category members GO Category GO:0033554 cellular response to stress Database 0
Category members GO Category GO:0042060 wound healing Database 0
Category members GO Category GO:0043113 receptor clustering Database 0
Category members GO Category GO:0043507 positive regulation of JUN kinase activity Database 0
Category members GO Category GO:0048754 branching morphogenesis of an epithelial tube Database 0
Category members GO Category GO:0048812 neuron projection morphogenesis Database 0
Category members GO Category GO:0051496 positive regulation of stress fiber assembly Database 0
Category members GO Category GO:0060244 negative regulation of cell proliferation involved in contact inhibition Database 0


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