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Query: AURKB

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AURKB 0 -1.063 -0.840 1.170 -0.562 -0.744 -0.302

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
AURKB Ubiquitylation K287 -0.625 _IVK(gl)VDLK_
AURKB Ubiquitylation K168 -0.421 -1.027 _ELQK(gl)SCTFDEQR_
AURKB Ubiquitylation K164 -1.041 _GELYK(gl)ELQK_
AURKB Ubiquitylation K87 -0.700 -1.401 _GK(gl)FGNVYLAR_
AURKB Ubiquitylation K56 -2.018 -2.920 _SNVQPTAAPGQK(gl)VMENSSGTPDILTR_

Background Information for AURKB:


Pubmed-AURKB »
Uniprot-AURKB »
Biogrid-AURKB »
ProteomicsDB-AURKB »

Tumorportal-AURKB »
COSMIC-AURKB »
GenomeRNAi-AURKB »
Genecards-AURKB


Protein-protein Interactions for AURKB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AURKB Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait TFG Cat. description Hein, Mann, Cell 2015
Category members IP bait AURKB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in AURKB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring AURKB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2579 Chromosomal passenger complex CPC (INCENP, BIRC5, AURKB) Database 0.18
Category members Corum 1087 BIRC5-AURKB-INCENP-EVI5 complex Database 0.05
Category members Corum 1116 CRM1-Survivin-AuroraB mitotic complex Database 0.05
Category members Corum 2581 RasGAP-AURKA/AURKB-survivin complex Database 0.05
Category members Corum 2582 Chromosomal passenger complex CPC (CDCA8, AURKB, BIRC5) Database 0.05
Category members Corum 1118 Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) Database 0
Category members Corum 1119 Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) Database 0


Categories featuring AURKB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Database 2.59
Category members Pathway Pathway_780 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 0 2.46
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members Pathway Pathway_788 REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 0 1.91
Category members Pathway Pathway_968 PID_FOXM1_PATHWAY 0 0.8
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0034644 cellular response to UV Database 0.49
Category members Pathway Pathway_911 PID_AURORA_B_PATHWAY 0 0.48
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0043146 spindle stabilization Database 0.37
Category members GO Category GO:0032467 positive regulation of cytokinesis Database 0.35
Category members Pathway Pathway_985 PID_AURORA_A_PATHWAY 0 0.34
Category members GO Category GO:0032133 chromosome passenger complex Database 0.29
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0000910 cytokinesis Database 0.15
Category members GO Category GO:0036089 cleavage furrow formation Database 0.09
Category members GO Category GO:0032091 negative regulation of protein binding Database 0.08
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0000780 condensed nuclear chromosome, centromeric region Database 0
Category members GO Category GO:0000779 condensed chromosome, centromeric region Database 0
Category members GO Category GO:0002903 negative regulation of B cell apoptotic process Database 0
Category members GO Category GO:0004712 protein serine/threonine/tyrosine kinase activity Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0008608 attachment of spindle microtubules to kinetochore Database 0
Category members GO Category GO:0010369 chromocenter Database 0
Category members GO Category GO:0016570 histone modification Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0034501 protein localization to kinetochore Database 0
Category members GO Category GO:0035174 histone serine kinase activity Database 0
Category members GO Category GO:0043988 histone H3-S28 phosphorylation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051256 spindle midzone assembly involved in mitosis Database 0
Category members GO Category GO:0051983 regulation of chromosome segregation Database 0


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