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Query: BIRC5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BIRC5 0 -0.818 -0.309 -0.536

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BIRC5 Ubiquitylation K113 0.088 -0.061 _HSSGCAFLSVK(gl)K_
BIRC5 Ubiquitylation K114 -0.061 _HSSGCAFLSVK(gl)K_
BIRC5 Ubiquitylation K15 -1.446 _(ac)GAPTLPPAWQPFLK(gl)DHR_

Background Information for BIRC5:


Pubmed-BIRC5 »
Uniprot-BIRC5 »
Biogrid-BIRC5 »
ProteomicsDB-BIRC5 »

Tumorportal-BIRC5 »
COSMIC-BIRC5 »
GenomeRNAi-BIRC5 »
Genecards-BIRC5


Protein-protein Interactions for BIRC5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BIRC5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BIRC5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members BIR IPR001370 0.04


Protein complexes (CORUM database) featuring BIRC5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2579 Chromosomal passenger complex CPC (INCENP, BIRC5, AURKB) Database 0.18
Category members Corum 1087 BIRC5-AURKB-INCENP-EVI5 complex Database 0.05
Category members Corum 1116 CRM1-Survivin-AuroraB mitotic complex Database 0.05
Category members Corum 2581 RasGAP-AURKA/AURKB-survivin complex Database 0.05
Category members Corum 2582 Chromosomal passenger complex CPC (CDCA8, AURKB, BIRC5) Database 0.05
Category members Corum 1117 CRM1-Survivin mitotic complex Database 0
Category members Corum 1118 Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) Database 0
Category members Corum 1119 Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) Database 0
Category members Corum 1120 Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5) Database 0


Categories featuring BIRC5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0051087 chaperone binding Database 1.69
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0051301 cell division Database 1.15
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0000228 nuclear chromosome Database 0.89
Category members GO Category GO:0015631 tubulin binding Database 0.83
Category members Pathway Pathway_968 PID_FOXM1_PATHWAY 0 0.8
Category members GO Category GO:0008017 microtubule binding Database 0.79
Category members GO Category GO:0005876 spindle microtubule Database 0.68
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0000226 microtubule cytoskeleton organization Database 0.5
Category members Pathway Pathway_911 PID_AURORA_B_PATHWAY 0 0.48
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0030496 midbody Database 0.39
Category members Pathway Pathway_985 PID_AURORA_A_PATHWAY 0 0.34
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0000777 condensed chromosome kinetochore Database 0.32
Category members GO Category GO:0000775 chromosome, centromeric region Database 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0032133 chromosome passenger complex Database 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0008536 Ran GTPase binding Database 0.21
Category members GO Category GO:0000910 cytokinesis Database 0.15
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0048037 cofactor binding Database 0.08
Category members GO Category GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process Database 0.05
Category members GO Category GO:0045931 positive regulation of mitotic cell cycle Database 0.04
Category members GO Category GO:0005881 cytoplasmic microtubule Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_544 BIOCARTA_BCELLSURVIVAL_PATHWAY 0 0
Category members GO Category GO:0004869 cysteine-type endopeptidase inhibitor activity Database 0
Category members GO Category GO:0005814 centriole Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0031503 protein complex localization Database 0
Category members GO Category GO:0031536 positive regulation of exit from mitosis Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050897 cobalt ion binding Database 0
Category members GO Category GO:0051303 establishment of chromosome localization Database 0


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