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Query: ARHGEF7

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ARHGEF7 0 2.728 -0.410 -0.070

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ARHGEF7 Phosphorylation S50 1.374 1.424 _IKS(ph)FDSLGSQSLHTR_
ARHGEF7 Phosphorylation S415 0.662 0.947 _M(ox)S(ph)GFIYQGK_
ARHGEF7 Phosphorylation S600 0.797 _S(ph)TAALEEDAQILK_
ARHGEF7 Phosphorylation T601 0.797 _S(ph)TAALEEDAQILK_
ARHGEF7 Phosphorylation S154 -0.198 0.140 _SGTLKS(ph)PPK_
ARHGEF7 Phosphorylation S635 0.061 -0.203 _KES(ph)APQVLLPEEEKIIVEETK_

Background Information for ARHGEF7:


Pubmed-ARHGEF7 »
Uniprot-ARHGEF7 »
Biogrid-ARHGEF7 »
ProteomicsDB-ARHGEF7 »

Tumorportal-ARHGEF7 »
COSMIC-ARHGEF7 »
GenomeRNAi-ARHGEF7 »
Genecards-ARHGEF7


Protein-protein Interactions for ARHGEF7
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PAK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC33A1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZBTB48 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARHGEF7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C1orf106 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAMK4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GIT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ICAM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPXN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCKIPSD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POTEB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYNC Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ARHGEF7
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members CH-domain IPR001715 0.63
Category members PH_domain IPR001849 0.14
Category members SH3_2 IPR011511 0.08
Category members DH-domain IPR000219 0.05
Category members SH3_domain IPR001452 0
Category members SH3-like_bac-type IPR003646 0


Protein complexes (CORUM database) featuring ARHGEF7
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 930 Scrib-beta-PIX-GIT1 complex Database 0.32


Categories featuring ARHGEF7
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0005938 cell cortex Database 2.26
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members Pathway Pathway_240 BIOCARTA_PAR1_PATHWAY 0 1.11
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0030032 lamellipodium assembly Database 0.66
Category members GO Category GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway Database 0.64
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_677 BIOCARTA_MYOSIN_PATHWAY 0 0.53
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_985 PID_AURORA_A_PATHWAY 0 0.34
Category members GO Category GO:0001726 ruffle Database 0.33
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members GO Category GO:0043547 positive regulation of GTPase activity Database 0.21
Category members GO Category GO:0035023 regulation of Rho protein signal transduction Database 0.17
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0005089 Rho guanyl-nucleotide exchange factor activity Database 0.08
Category members Pathway Pathway_293 PID_CDC42_REG_PATHWAY 0 0.05
Category members Pathway Pathway_1157 PID_RAC1_REG_PATHWAY 0 0
Category members Pathway Pathway_538 PID_ERBB1_INTERNALIZATION_PATHWAY 0 0
Category members GO Category GO:0005085 guanyl-nucleotide exchange factor activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0


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