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Query: AURKA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AURKA 0 -4.568 -0.450 -0.060 -2.905 -1.603

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for AURKA:


Pubmed-AURKA »
Uniprot-AURKA »
Biogrid-AURKA »
ProteomicsDB-AURKA »

Tumorportal-AURKA »
COSMIC-AURKA »
GenomeRNAi-AURKA »
Genecards-AURKA


Protein-protein Interactions for AURKA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AURKA Cat. description Hein, Mann, Cell 2015
Category members IP bait ARFGAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AURKA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C11orf48 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C16orf71 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CELA2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM131B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FEZ1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KHDRBS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIRREL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLRG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYCL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PAK7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLA2G10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP6R2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKCSH Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in AURKA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring AURKA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 631 Tacc1-chTOG-AuroraA complex Database 0.04


Categories featuring AURKA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members GO Category GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Database 2.59
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_780 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 0 2.46
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_788 REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 0 1.91
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0005876 spindle microtubule Database 0.68
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members Pathway Pathway_911 PID_AURORA_B_PATHWAY 0 0.48
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0043146 spindle stabilization Database 0.37
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_1255 BIOCARTA_RANMS_PATHWAY 0 0.35
Category members Pathway Pathway_985 PID_AURORA_A_PATHWAY 0 0.34
Category members GO Category GO:0031616 spindle pole centrosome Database 0.27
Category members GO Category GO:0046605 regulation of centrosome cycle Database 0.24
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0031647 regulation of protein stability Database 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_1028 PID_PLK1_PATHWAY 0 0.16
Category members GO Category GO:0032091 negative regulation of protein binding Database 0.08
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0007051 spindle organization Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0004712 protein serine/threonine/tyrosine kinase activity Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0030030 cell projection organization Database 0
Category members GO Category GO:0045840 positive regulation of mitosis Database 0


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