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Query: CHEK1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CHEK1 2 6.092 -1.170 1.560

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CHEK1 Phosphorylation S317 1.903 _HIQSNLDFS(ph)PVNSASSEENVK_
CHEK1 Phosphorylation S300 1.091 _VTSGGVS(ph)ESPSGFSK_
CHEK1 Phosphorylation S296 -0.098 0.184 _VTS(ph)GGVSESPSGFSK_
CHEK1 Phosphorylation S302 1.750 _VTSGGVSES(ph)PSGFSK_
CHEK1 Ubiquitylation K53 0.879 _AVDCPENIK(gl)K_
CHEK1 Ubiquitylation K54 0.738 _AVDCPENIKK(gl)_
CHEK1 Ubiquitylation K399 -0.582 _ETCEK(gl)LGYQWK_

Background Information for CHEK1:


Pubmed-CHEK1 »
Uniprot-CHEK1 »
Biogrid-CHEK1 »
ProteomicsDB-CHEK1 »

Tumorportal-CHEK1 »
COSMIC-CHEK1 »
GenomeRNAi-CHEK1 »
Genecards-CHEK1


Protein-protein Interactions for CHEK1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHEK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BCL2L14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHRNA9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTSE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ERCC6L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-DRB5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL13RA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LDLRAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NAT9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NELL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLA2G10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RACGAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCEAL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UNC5CL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAV1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CHEK1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring CHEK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2171 Ubiquitin E3 ligase (CHEK1, CUL4A) Database 0.34
Category members Corum 2714 Ubiquitin E3 ligase (CHEK1, CUL1) Database 0.34


Categories featuring CHEK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_865 PID_ATR_PATHWAY 0 3.46
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0000785 chromatin Database 2.59
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0000077 DNA damage checkpoint Database 2.04
Category members Pathway Pathway_798 REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT 0 1.64
Category members GO Category GO:0000794 condensed nuclear chromosome Database 1.58
Category members Pathway Pathway_864 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS 0 1.21
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members GO Category GO:0005657 replication fork Database 0.95
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_863 REACTOME_G2_M_CHECKPOINTS 0 0.74
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0048096 chromatin-mediated maintenance of transcription Database 0.6
Category members Pathway Pathway_979 BIOCARTA_ATRBRCA_PATHWAY 0 0.6
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members Pathway Pathway_980 BIOCARTA_ATM_PATHWAY 0 0.46
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members Pathway Pathway_982 BIOCARTA_G2_PATHWAY 0 0.24
Category members Pathway Pathway_1248 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT 0 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0035402 histone kinase activity (H3-T11 specific) Database 0.18
Category members GO Category GO:0000781 chromosome, telomeric region Database 0.16
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0045839 negative regulation of mitosis Database 0.08
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0010569 regulation of double-strand break repair via homologous recombination Database 0.01
Category members GO Category GO:0018107 peptidyl-threonine phosphorylation Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1030 BIOCARTA_RB_PATHWAY 0 0
Category members Pathway Pathway_1249 PID_CIRCADIAN_PATHWAY 0 0
Category members Pathway Pathway_972 SA_G2_AND_M_PHASES 0 0
Category members GO Category GO:0006975 DNA damage induced protein phosphorylation Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0031572 G2 DNA damage checkpoint Database 0
Category members GO Category GO:0046602 regulation of mitotic centrosome separation Database 0
Category members GO Category GO:0071260 cellular response to mechanical stimulus Database 0
Category members GO Category GO:0071310 cellular response to organic substance Database 0
Category members GO Category GO:0071313 cellular response to caffeine Database 0


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