bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: MCM3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MCM3 1 9.101 -1.860 3.650 1.197 0.554 0.207

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MCM3 Ubiquitylation K311 0.886 1.210 _TVLIACNVK(gl)QMSK_
MCM3 Phosphorylation S713 0.697 _S(ph)EDESETEDEEEKSQEDQEQK_
MCM3 Phosphorylation T209 0.700 0.517 _RYSDLTT(ph)LVAFPSSSVYPTK_
MCM3 Phosphorylation S717 0.009 0.302 _SEDES(ph)ETEDEEEK_
MCM3 Ubiquitylation K480 0.706 0.010 _VTIAK(gl)AGIHAR_
MCM3 Phosphorylation T767 -0.699 -0.088 _DGDSYDPYDFSDTEEEMPQVHT(ph)PK_
MCM3 Phosphorylation S205 0.571 -0.326 _RYS(ph)DLTTLVAFPSSSVYPTK_
MCM3 Ubiquitylation K781 -0.081 -0.408 _ESQK(gl)VELSESR_
MCM3 Phosphorylation S756 -0.581 -0.455 _DGDSYDPYDFS(ph)DTEEEMPQVHTPK_
MCM3 Ubiquitylation K293 0.760 -0.751 _K(gl)GGYTSGTFR_
MCM3 Ubiquitylation K198 -0.209 -1.171 _SVHYCPATKK(gl)_
MCM3 Ubiquitylation K508 -0.031 _YDQYK(gl)TPMENIGLQDSLLSR_
MCM3 Phosphorylation T758 -0.622 _DGDSYDPYDFS(ph)DTEEEM(ox)PQVHTPK_
MCM3 Ubiquitylation K777 -0.521 _TADSQETK(gl)ESQKVELSESR_

Background Information for MCM3:


Pubmed-MCM3 »
Uniprot-MCM3 »
Biogrid-MCM3 »
ProteomicsDB-MCM3 »

Tumorportal-MCM3 »
COSMIC-MCM3 »
GenomeRNAi-MCM3 »
Genecards-MCM3


Protein-protein Interactions for MCM3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CLSPN Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM6 Cat. description Hein, Mann, Cell 2015
Category members IP bait TIMELESS Cat. description Hein, Mann, Cell 2015
Category members IP bait TIPIN Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM188A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NAGK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RABGGTB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TIPIN Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MCM3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members P-loop_NTPase IPR027417 2.83
Category members Mg_chelatse_chII IPR000523 0.94
Category members MCM_DNA-dep_ATPase IPR001208 0.93
Category members AAA+_ATPase IPR003593 0.38


Protein complexes (CORUM database) featuring MCM3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 387 MCM complex Database 1.91
Category members Corum 5449 Splicing-associated factors complex Database 0.5


Categories featuring MCM3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0003678 DNA helicase activity Database 2.22
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_820 REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 0 1.75
Category members Pathway Pathway_787 REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 0 1.59
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_331 REACTOME_M_G1_TRANSITION 0 1.43
Category members GO Category GO:0042555 MCM complex Database 1.41
Category members GO Category GO:0015979 photosynthesis Database 1.35
Category members GO Category GO:0015995 chlorophyll biosynthetic process Database 1.35
Category members GO Category GO:0016851 magnesium chelatase activity Database 1.35
Category members GO Category GO:0006271 DNA strand elongation involved in DNA replication Database 1.33
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_864 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS 0 1.21
Category members Pathway Pathway_329 KEGG_DNA_REPLICATION 0 0.95
Category members Pathway Pathway_327 REACTOME_DNA_STRAND_ELONGATION 0 0.9
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_863 REACTOME_G2_M_CHECKPOINTS 0 0.74
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0006270 DNA replication initiation Database 0.57
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members Pathway Pathway_868 REACTOME_UNWINDING_OF_DNA 0 0.44
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_318 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 0 0.25
Category members Pathway Pathway_867 BIOCARTA_MCM_PATHWAY 0 0.1
Category members GO Category GO:0005658 alpha DNA polymerase:primase complex Database 0


.

© Copyright Svejstrup Laboratory 2015