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Query: MCM2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MCM2 2 7.110 0.740 -0.140
MCM2 2 7.110 0.740 -0.140 0.552 0.052
MCM2 2 7.110 0.740 -0.140 1.288

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MCM2 Phosphorylation S108 1.832 2.212 _AIPELDAYEAEGLALDDEDVEELTAS(ph)QR_
MCM2 Phosphorylation T106 2.035 2.162 _AIPELDAYEAEGLALDDEDVEELT(ph)ASQR_
MCM2 Phosphorylation S40 0.648 1.028 _TDALTS(ph)SPGR_
MCM2 Phosphorylation T9 0.528 0.894 _(ac)AESSESFT(ph)MASSPAQR_
MCM2 Phosphorylation S41 0.613 0.869 _RTDALTSS(ph)PGR_
MCM2 Phosphorylation S13 0.595 0.841 _(ac)AESSESFTMASS(ph)PAQR_
MCM2 Ubiquitylation K205 0.225 0.747 _ISDMCK(gl)ENR_
MCM2 Phosphorylation S12 0.027 0.508 _AESSESFTMAS(ph)SPAQR_
MCM2 Phosphorylation S139 0.404 0.482 _GLLYDS(ph)DEEDEERPAR_
MCM2 Ubiquitylation K450 0.216 0.470 _MITSLSK(gl)DQQIGEK_
MCM2 Ubiquitylation K365 -0.341 0.407 _IQESPGK(gl)VAAGR_
MCM2 Phosphorylation S27 0.076 0.378 _GNDPLTSS(ph)PGR_
MCM2 Phosphorylation S5 0.653 0.313 _(ac)AESS(ph)ESFTMASSPAQR_
MCM2 Phosphorylation S26 0.334 0.204 _GNDPLTS(ph)SPGR_
MCM2 Phosphorylation S4 0.060 -0.102 _(ac)AES(ph)SESFTM(ox)ASS(ph)PAQR_
MCM2 Ubiquitylation K946 -0.032 _FSHDLK(gl)R_

Background Information for MCM2:


Pubmed-MCM2 »
Uniprot-MCM2 »
Biogrid-MCM2 »
ProteomicsDB-MCM2 »

Tumorportal-MCM2 »
COSMIC-MCM2 »
GenomeRNAi-MCM2 »
Genecards-MCM2


Protein-protein Interactions for MCM2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CLSPN Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM6 Cat. description Hein, Mann, Cell 2015
Category members IP bait TIMELESS Cat. description Hein, Mann, Cell 2015
Category members IP bait ASF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASF1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait H2AFX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait H2AFY2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H2BA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait L3MBTL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MCM3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NAA40 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPIN2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSRP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MCM2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members P-loop_NTPase IPR027417 2.83
Category members ATPase_dyneun-rel_AAA IPR011704 2.54
Category members Mg_chelatse_chII IPR000523 0.94
Category members MCM_DNA-dep_ATPase IPR001208 0.93
Category members ATPase_AAA-3 IPR011703 0.65


Protein complexes (CORUM database) featuring MCM2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 387 MCM complex Database 1.91
Category members Corum 5611 Emerin complex 24 Database 1.05
Category members Corum 2792 MCM2-MCM4-MCM6-MCM7 complex Database 0.93
Category members Corum 1452 MCM2-MCM6-MCM7 complex Database 0.52


Categories featuring MCM2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0006334 nucleosome assembly Database 3.77
Category members Pathway Pathway_865 PID_ATR_PATHWAY 0 3.46
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0003678 DNA helicase activity Database 2.22
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_820 REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 0 1.75
Category members Pathway Pathway_787 REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 0 1.59
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_331 REACTOME_M_G1_TRANSITION 0 1.43
Category members GO Category GO:0042555 MCM complex Database 1.41
Category members GO Category GO:0015979 photosynthesis Database 1.35
Category members GO Category GO:0015995 chlorophyll biosynthetic process Database 1.35
Category members GO Category GO:0016851 magnesium chelatase activity Database 1.35
Category members GO Category GO:0006271 DNA strand elongation involved in DNA replication Database 1.33
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_864 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS 0 1.21
Category members Pathway Pathway_329 KEGG_DNA_REPLICATION 0 0.95
Category members GO Category GO:0042393 histone binding Database 0.94
Category members Pathway Pathway_327 REACTOME_DNA_STRAND_ELONGATION 0 0.9
Category members Pathway Pathway_863 REACTOME_G2_M_CHECKPOINTS 0 0.74
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0006270 DNA replication initiation Database 0.57
Category members Pathway Pathway_868 REACTOME_UNWINDING_OF_DNA 0 0.44
Category members Pathway Pathway_318 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 0 0.25
Category members GO Category GO:0006268 DNA unwinding involved in DNA replication Database 0.19
Category members GO Category GO:0071353 cellular response to interleukin-4 Database 0.19
Category members Pathway Pathway_867 BIOCARTA_MCM_PATHWAY 0 0.1
Category members GO Category GO:0003688 DNA replication origin binding Database 0
Category members GO Category GO:0005664 nuclear origin of replication recognition complex Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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