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Query: PRIM1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRIM1 0 2.304 -0.690 0.980

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRIM1 Ubiquitylation K147 1.418 _ALK(gl)EDFGFK_
PRIM1 Ubiquitylation K326 -0.141 -1.351 _SPFSVHPK(gl)TGR_
PRIM1 Ubiquitylation K377 -0.093 _ELDAISTNEEEKEENEAESDVK(gl)HR_

Background Information for PRIM1:


Pubmed-PRIM1 »
Uniprot-PRIM1 »
Biogrid-PRIM1 »
ProteomicsDB-PRIM1 »

Tumorportal-PRIM1 »
COSMIC-PRIM1 »
GenomeRNAi-PRIM1 »
Genecards-PRIM1


Protein-protein Interactions for PRIM1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MAD2L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait AKD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C6orf141 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCAF10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LIPH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCAPH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NLGN4Y Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OBFC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF31 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRIM1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DNA_primase_S IPR002755 0.17


Protein complexes (CORUM database) featuring PRIM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1098 DNA synthesome complex (13 subunits) Database 0.35
Category members Corum 1099 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 1111 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 1100 DNA polymerase alpha-primase complex Database 0
Category members Corum 1107 DNA synthesome core complex Database 0
Category members Corum 1108 DNA synthesome complex (15 subunits) Database 0


Categories featuring PRIM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_331 REACTOME_M_G1_TRANSITION 0 1.43
Category members GO Category GO:0006271 DNA strand elongation involved in DNA replication Database 1.33
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_329 KEGG_DNA_REPLICATION 0 0.95
Category members Pathway Pathway_327 REACTOME_DNA_STRAND_ELONGATION 0 0.9
Category members GO Category GO:0000722 telomere maintenance via recombination Database 0.64
Category members GO Category GO:0006270 DNA replication initiation Database 0.57
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members GO Category GO:0032201 telomere maintenance via semi-conservative replication Database 0.35
Category members Pathway Pathway_324 REACTOME_EXTENSION_OF_TELOMERES 0 0.33
Category members Pathway Pathway_318 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 0 0.25
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_311 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND 0 0.2
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members Pathway Pathway_316 REACTOME_LAGGING_STRAND_SYNTHESIS 0 0.11
Category members Pathway Pathway_312 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 0 0.11
Category members Pathway Pathway_314 REACTOME_POL_SWITCHING 0 0
Category members GO Category GO:0003896 DNA primase activity Database 0
Category members GO Category GO:0006269 DNA replication, synthesis of RNA primer Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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