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Query: CDT1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDT1 1 -2.375 -0.050 -0.180

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDT1 Ubiquitylation K377 3.560 _MEK(gl)ALSQLALR_
CDT1 Ubiquitylation K24 -3.025 1.688 _IAPPK(gl)LACR_
CDT1 Ubiquitylation K259 1.150 _SVPTFK(gl)DGTR_
CDT1 Ubiquitylation K218 0.676 _SETPTFAK(gl)VQR_
CDT1 Ubiquitylation K522 0.136 _TDTYVK(gl)LDK_
CDT1 Ubiquitylation K102 0.013 _NVGQIK(gl)TVYPASYR_
CDT1 Phosphorylation S318 -2.552 -0.359 _AFLASLS(ph)PAMVVPEDQLTR_
CDT1 Phosphorylation S316 -0.503 _AFLAS(ph)LSPAMVVPEDQLTR_
CDT1 Phosphorylation T29 -0.527 _T(ph)PSPARPALR_
CDT1 Phosphorylation S411 -1.380 _PALPATPPATPPAAS(ph)PSALK_
CDT1 Phosphorylation S73 -1.743 _LRLS(ph)VDEVSSPSTPEAPDIPACPSPGQK_
CDT1 Phosphorylation S93 -2.789 _LSVDEVSSPSTPEAPDIPACPS(ph)PGQK_

Background Information for CDT1:


Pubmed-CDT1 »
Uniprot-CDT1 »
Biogrid-CDT1 »
ProteomicsDB-CDT1 »

Tumorportal-CDT1 »
COSMIC-CDT1 »
GenomeRNAi-CDT1 »
Genecards-CDT1


Protein-protein Interactions for CDT1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCNA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GMNN Cat. description Hein, Mann, Cell 2015
Category members IP bait OSGEP Cat. description Hein, Mann, Cell 2015
Category members IP bait SLAIN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait VPS4B Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CKS1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CKS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GMNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDT1
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring CDT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2172 Ubiquitin E3 ligase (CDT1, DDB1, CUL4A, RBX1) Database 0.04


Categories featuring CDT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_820 REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 0 1.75
Category members Pathway Pathway_787 REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 0 1.59
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_331 REACTOME_M_G1_TRANSITION 0 1.43
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_828 REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX 0 0.82
Category members Pathway Pathway_326 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION 0 0.49
Category members Disease phenotype Ear-patella-short_stature_syndrome Ear-patella-short stature syndrome Database 0.4
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members GO Category GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Database 0.34
Category members Pathway Pathway_318 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 0 0.25
Category members Pathway Pathway_778 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX 0 0.1
Category members Pathway Pathway_867 BIOCARTA_MCM_PATHWAY 0 0.1
Category members GO Category GO:0033262 regulation of nuclear cell cycle DNA replication Database 0.08
Category members GO Category GO:0030174 regulation of DNA-dependent DNA replication initiation Database 0.04
Category members GO Category GO:0000076 DNA replication checkpoint Database 0


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