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Query: MCM7

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MCM7 0 2.366 -0.260 -0.010 0.361 -0.040
MCM7 0 2.366 -0.260 -0.010 0.592

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MCM7 Phosphorylation S121 0.902 0.509 _S(ph)PQNQYPAELMR_
MCM7 Ubiquitylation K29 -1.023 -0.094 _FLQEFYQDDELGKK(gl)QFK_
MCM7 Ubiquitylation K648 -0.422 -0.441 _DSLLGDK(gl)GQTAR_
MCM7 Ubiquitylation K159 0.038 -0.495 _ADSVGK(gl)LVTVR_
MCM7 Ubiquitylation K596 -0.751 -0.539 _REAWASK(gl)DATYTSAR_
MCM7 Ubiquitylation K627 -0.965 -0.588 _MVDVVEK(gl)EDVNEAIR_
MCM7 Ubiquitylation K28 -0.102 -0.861 _FLQEFYQDDELGK(gl)K_
MCM7 Ubiquitylation K641 -0.836 -0.945 _LMEMSK(gl)DSLLGDKGQTAR_
MCM7 Ubiquitylation K231 -0.965 _FIK(gl)FQEMK_
MCM7 Ubiquitylation K32 0.146 -0.970 _QFK(gl)YGNQLVR_
MCM7 Ubiquitylation K4 -1.164 _(ac)ALK(gl)DYALEKEK_
MCM7 Ubiquitylation K89 -1.906 -1.328 _LFADAVQELLPQYK(gl)ER_
MCM7 Ubiquitylation K10 -0.334 -1.453 _(ac)ALKDYALEK(gl)EK_
MCM7 Ubiquitylation K352 -1.468 _LAASIAPEIYGHEDVKK(gl)_
MCM7 Ubiquitylation K12 -1.492 _DYALEK(gl)EK_
MCM7 Ubiquitylation K236 -1.769 _FQEMK(gl)MQEHSDQVPVGNIPR_
MCM7 Ubiquitylation K557 -2.556 -2.098 _QPPSQFEPLDMK(gl)LMR_
MCM7 Ubiquitylation K145 -2.703 _RFELYFQGPSSNK(gl)PR_

Background Information for MCM7:


Pubmed-MCM7 »
Uniprot-MCM7 »
Biogrid-MCM7 »
ProteomicsDB-MCM7 »

Tumorportal-MCM7 »
COSMIC-MCM7 »
GenomeRNAi-MCM7 »
Genecards-MCM7


Protein-protein Interactions for MCM7
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CLSPN Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM6 Cat. description Hein, Mann, Cell 2015
Category members IP bait TIMELESS Cat. description Hein, Mann, Cell 2015
Category members IP bait ASF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASF1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GINS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H2BA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MCM10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MCM3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MCM7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSRP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MCM7
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members P-loop_NTPase IPR027417 2.83
Category members ATPase_dyneun-rel_AAA IPR011704 2.54
Category members Mg_chelatse_chII IPR000523 0.94
Category members MCM_DNA-dep_ATPase IPR001208 0.93
Category members AAA+_ATPase IPR003593 0.38
Category members MCM_4 IPR008047 0.21


Protein complexes (CORUM database) featuring MCM7
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 387 MCM complex Database 1.91
Category members Corum 2792 MCM2-MCM4-MCM6-MCM7 complex Database 0.93
Category members Corum 1452 MCM2-MCM6-MCM7 complex Database 0.52
Category members Corum 2791 MCM4-MCM6-MCM7 complex Database 0.52


Categories featuring MCM7
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_865 PID_ATR_PATHWAY 0 3.46
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0003678 DNA helicase activity Database 2.22
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_820 REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 0 1.75
Category members Pathway Pathway_787 REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 0 1.59
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_331 REACTOME_M_G1_TRANSITION 0 1.43
Category members GO Category GO:0042555 MCM complex Database 1.41
Category members GO Category GO:0015979 photosynthesis Database 1.35
Category members GO Category GO:0015995 chlorophyll biosynthetic process Database 1.35
Category members GO Category GO:0016851 magnesium chelatase activity Database 1.35
Category members GO Category GO:0006271 DNA strand elongation involved in DNA replication Database 1.33
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_864 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS 0 1.21
Category members Pathway Pathway_329 KEGG_DNA_REPLICATION 0 0.95
Category members Pathway Pathway_327 REACTOME_DNA_STRAND_ELONGATION 0 0.9
Category members Pathway Pathway_863 REACTOME_G2_M_CHECKPOINTS 0 0.74
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0006270 DNA replication initiation Database 0.57
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members Pathway Pathway_868 REACTOME_UNWINDING_OF_DNA 0 0.44
Category members Pathway Pathway_318 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 0 0.25
Category members GO Category GO:0006268 DNA unwinding involved in DNA replication Database 0.19
Category members Pathway Pathway_867 BIOCARTA_MCM_PATHWAY 0 0.1
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0042325 regulation of phosphorylation Database 0
Category members GO Category GO:0071310 cellular response to organic substance Database 0
Category members GO Category GO:0071364 cellular response to epidermal growth factor stimulus Database 0


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