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Query: MCM4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MCM4 0 3.588 0.700 0.170 0.876 0.344 -0.023 0.237 0.753

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MCM4 Phosphorylation S26 -0.380 0.511 _ATPAQTPRS(ph)EDAR_
MCM4 Phosphorylation S131 0.424 0.474 _GLQVDLQS(ph)DGAAAEDIVASEQSLGQK_
MCM4 Ubiquitylation K220 -0.271 0.326 _SFDK(gl)NLYR_
MCM4 Phosphorylation S326 0.118 0.226 _IAEPS(ph)VCGR_
MCM4 Ubiquitylation K746 -0.079 _LAEAHAK(gl)VR_
MCM4 Ubiquitylation K478 -0.439 _LASALAPSIYEHEDIKK(gl)_
MCM4 Ubiquitylation K409 0.140 -0.445 _VSNVK(gl)SVYK_
MCM4 Ubiquitylation K353 -0.534 _SLFSDKQMIK(gl)_
MCM4 Ubiquitylation K762 -0.483 -0.551 _VEAIDVEEAK(gl)R_
MCM4 Ubiquitylation K450 -0.607 _VELLK(gl)ELSR_
MCM4 Ubiquitylation K549 -0.023 -0.647 _GSSAVGLTAYVMK(gl)DPETR_
MCM4 Ubiquitylation K770 -0.963 -0.688 _EALK(gl)QSATDPR_
MCM4 Ubiquitylation K752 -0.885 -0.700 _LSNK(gl)VEAIDVEEAK(gl)R_
MCM4 Ubiquitylation K536 -0.941 -0.853 _GQYTSGK(gl)GSSAVGLTAYVMKDPETR_
MCM4 Ubiquitylation K814 -1.087 _GK(gl)TPALK_
MCM4 Ubiquitylation K628 -1.124 -3.224 _TSVLAAANPIESQWNPKK(gl)_
MCM4 Ubiquitylation K858 0.042 _ALADDDFLTVTGK(gl)TVR_

Background Information for MCM4:


Pubmed-MCM4 »
Uniprot-MCM4 »
Biogrid-MCM4 »
ProteomicsDB-MCM4 »

Tumorportal-MCM4 »
COSMIC-MCM4 »
GenomeRNAi-MCM4 »
Genecards-MCM4


Protein-protein Interactions for MCM4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CLSPN Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM6 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP153 Cat. description Hein, Mann, Cell 2015
Category members IP bait ASF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASF1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CENPA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait H2AFX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait H2AFY2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H2BA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait L3MBTL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MCM10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MCM3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSRP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MCM4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members P-loop_NTPase IPR027417 2.83
Category members ATPase_dyneun-rel_AAA IPR011704 2.54
Category members Mg_chelatse_chII IPR000523 0.94
Category members MCM_DNA-dep_ATPase IPR001208 0.93
Category members ATPase_AAA-3 IPR011703 0.65
Category members MCM_4 IPR008047 0.21


Protein complexes (CORUM database) featuring MCM4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 387 MCM complex Database 1.91
Category members Corum 5611 Emerin complex 24 Database 1.05
Category members Corum 2792 MCM2-MCM4-MCM6-MCM7 complex Database 0.93
Category members Corum 2791 MCM4-MCM6-MCM7 complex Database 0.52


Categories featuring MCM4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0003678 DNA helicase activity Database 2.22
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_820 REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 0 1.75
Category members Pathway Pathway_787 REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 0 1.59
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_331 REACTOME_M_G1_TRANSITION 0 1.43
Category members GO Category GO:0042555 MCM complex Database 1.41
Category members GO Category GO:0015979 photosynthesis Database 1.35
Category members GO Category GO:0015995 chlorophyll biosynthetic process Database 1.35
Category members GO Category GO:0016851 magnesium chelatase activity Database 1.35
Category members GO Category GO:0006271 DNA strand elongation involved in DNA replication Database 1.33
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_864 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS 0 1.21
Category members Pathway Pathway_329 KEGG_DNA_REPLICATION 0 0.95
Category members Pathway Pathway_327 REACTOME_DNA_STRAND_ELONGATION 0 0.9
Category members Pathway Pathway_863 REACTOME_G2_M_CHECKPOINTS 0 0.74
Category members GO Category GO:0006270 DNA replication initiation Database 0.57
Category members Pathway Pathway_868 REACTOME_UNWINDING_OF_DNA 0 0.44
Category members Pathway Pathway_318 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 0 0.25
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members GO Category GO:0006268 DNA unwinding involved in DNA replication Database 0.19
Category members Pathway Pathway_867 BIOCARTA_MCM_PATHWAY 0 0.1


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