bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: MCM6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MCM6 2 12.361 -0.170 -0.180 1.067 0.473 -0.065

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MCM6 Phosphorylation S13 4.283 4.775 _(ac)M(ox)DLAAAAEPGAGS(ph)QHLEVRDEVAEK_
MCM6 Phosphorylation S758 0.528 2.700 _EIES(ph)EIDSEEELINK_
MCM6 Phosphorylation S762 1.561 1.325 _EIESEIDS(ph)EEELINK_
MCM6 Ubiquitylation K197 0.461 0.797 _FLLDTNK(gl)SR_
MCM6 Ubiquitylation K332 0.272 0.709 _NQMTVK(gl)EWEK_
MCM6 Ubiquitylation K611 1.032 0.016 _DGSGVTK(gl)SSWR_
MCM6 Ubiquitylation K654 0.288 -0.028 _LLNK(gl)SIIR_
MCM6 Ubiquitylation K744 -0.152 -0.415 _KVEEEEDESALK(gl)R_
MCM6 Ubiquitylation K517 0.150 -0.502 _SLK(gl)QNINLSAPIMSR_
MCM6 Ubiquitylation K95 0.656 _ALK(gl)TFVK_
MCM6 Ubiquitylation K422 0.854 _AVYTSGK(gl)ASSAAGLTAAVVR_
MCM6 Ubiquitylation K490 0.630 _AGVK(gl)ATLNAR_
MCM6 Ubiquitylation K643 -0.198 _MHCCDEVQPK(gl)HVK_
MCM6 Ubiquitylation K775 0.748 _IIEK(gl)VIHR_

Background Information for MCM6:


Pubmed-MCM6 »
Uniprot-MCM6 »
Biogrid-MCM6 »
ProteomicsDB-MCM6 »

Tumorportal-MCM6 »
COSMIC-MCM6 »
GenomeRNAi-MCM6 »
Genecards-MCM6


Protein-protein Interactions for MCM6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLSPN Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MCM6 Cat. description Hein, Mann, Cell 2015
Category members IP bait TIMELESS Cat. description Hein, Mann, Cell 2015
Category members IP bait ASF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASF1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait H2AFX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H2BA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H4A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MCM10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MCM3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPIN2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSRP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MCM6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members P-loop_NTPase IPR027417 2.83
Category members Mg_chelatse_chII IPR000523 0.94
Category members MCM_DNA-dep_ATPase IPR001208 0.93


Protein complexes (CORUM database) featuring MCM6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 387 MCM complex Database 1.91
Category members Corum 5611 Emerin complex 24 Database 1.05
Category members Corum 2792 MCM2-MCM4-MCM6-MCM7 complex Database 0.93
Category members Corum 1452 MCM2-MCM6-MCM7 complex Database 0.52
Category members Corum 2791 MCM4-MCM6-MCM7 complex Database 0.52


Categories featuring MCM6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0003678 DNA helicase activity Database 2.22
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_820 REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 0 1.75
Category members Pathway Pathway_787 REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 0 1.59
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_331 REACTOME_M_G1_TRANSITION 0 1.43
Category members GO Category GO:0042555 MCM complex Database 1.41
Category members GO Category GO:0015979 photosynthesis Database 1.35
Category members GO Category GO:0015995 chlorophyll biosynthetic process Database 1.35
Category members GO Category GO:0016851 magnesium chelatase activity Database 1.35
Category members GO Category GO:0006271 DNA strand elongation involved in DNA replication Database 1.33
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_864 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS 0 1.21
Category members Pathway Pathway_329 KEGG_DNA_REPLICATION 0 0.95
Category members Pathway Pathway_327 REACTOME_DNA_STRAND_ELONGATION 0 0.9
Category members Pathway Pathway_863 REACTOME_G2_M_CHECKPOINTS 0 0.74
Category members GO Category GO:0006270 DNA replication initiation Database 0.57
Category members Pathway Pathway_868 REACTOME_UNWINDING_OF_DNA 0 0.44
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_318 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 0 0.25
Category members GO Category GO:0006268 DNA unwinding involved in DNA replication Database 0.19
Category members Pathway Pathway_867 BIOCARTA_MCM_PATHWAY 0 0.1


.

© Copyright Svejstrup Laboratory 2015