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Query: POLE

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
POLE 0 -0.869 -0.404 0.128 -0.376 -0.212
POLE 0 -0.869 -0.273

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
POLE Ubiquitylation K436 -0.163 _DSYLPVGSHNLK(gl)AAAK_
POLE Ubiquitylation K1587 -0.722 _FLLAYK(gl)EER_
POLE Ubiquitylation K187 -0.801 _EISPAVKK(gl)_
POLE Ubiquitylation K1573 -0.910 _AETDLK(gl)TICR_
POLE Ubiquitylation K1385 -1.054 -0.957 _VAK(gl)AEEGASYR_
POLE Ubiquitylation K2135 -0.740 -1.214 _VLSLDTNITNQVNK(gl)LNR_
POLE Ubiquitylation K1081 -1.440 _LAEFLGDQMVK(gl)DAGLSCR_
POLE Ubiquitylation K1061 -1.582 _KLEDYGEQK(gl)STSISTAK_
POLE Ubiquitylation K2121 0.432 _YVCK(gl)VLSLDTNITNQVNK_

Background Information for POLE:


Pubmed-POLE »
Uniprot-POLE »
Biogrid-POLE »
ProteomicsDB-POLE »

Tumorportal-POLE »
COSMIC-POLE »
GenomeRNAi-POLE »
Genecards-POLE


Protein-protein Interactions for POLE
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C16orf45 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKKL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNAJC7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS3BP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LYPD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBBX Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in POLE
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DNA-dir_DNA_pol_B_exonuc IPR006133 0
Category members DNA-dir_DNA_pol_B_multi_dom IPR006134 0
Category members DNA-dir_DNA_pol_B IPR006172 0
Category members RNaseH-like_dom IPR012337 0


Protein complexes (CORUM database) featuring POLE
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1004 RC complex during S-phase of cell cycle Database 0.79
Category members Corum 1005 RC complex during G2/M-phase of cell cycle Database 0.67
Category members Corum 1099 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 1111 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 1108 DNA synthesome complex (15 subunits) Database 0


Categories featuring POLE
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members Pathway Pathway_344 REACTOME_GLOBAL_GENOMIC_NER_GG_NER 0 3.29
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_331 REACTOME_M_G1_TRANSITION 0 1.43
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_329 KEGG_DNA_REPLICATION 0 0.95
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0000722 telomere maintenance via recombination Database 0.64
Category members GO Category GO:0006270 DNA replication initiation Database 0.57
Category members GO Category GO:0006287 base-excision repair, gap-filling Database 0.48
Category members GO Category GO:0032201 telomere maintenance via semi-conservative replication Database 0.35
Category members Pathway Pathway_324 REACTOME_EXTENSION_OF_TELOMERES 0 0.33
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members Pathway Pathway_318 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 0 0.25
Category members GO Category GO:0006297 nucleotide-excision repair, DNA gap filling Database 0.25
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members Pathway Pathway_333 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER 0 0.08
Category members GO Category GO:0006139 nucleobase-containing compound metabolic process Database 0.08
Category members Pathway Pathway_334 KEGG_BASE_EXCISION_REPAIR 0 0
Category members GO Category GO:0000731 DNA synthesis involved in DNA repair Database 0
Category members GO Category GO:0003887 DNA-directed DNA polymerase activity Database 0
Category members GO Category GO:0008622 epsilon DNA polymerase complex Database 0
Category members GO Category GO:0051539 4 iron, 4 sulfur cluster binding Database 0


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