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Query: POLD1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
POLD1 0 -0.450 1.600 -1.300
POLD1 0 -0.450 1.600 -1.300 -0.932 0.362 0.283

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
POLD1 Ubiquitylation K758 -0.638 _TK(gl)QLVESK_
POLD1 Ubiquitylation K554 -0.798 _GQQVK(gl)VVSQLLR_
POLD1 Ubiquitylation K911 -0.089 -0.915 _IDISQLVITK(gl)ELTR_
POLD1 Ubiquitylation K1033 0.475 -0.930 _VGGLLAFAK(gl)R_
POLD1 Ubiquitylation K439 -1.108 _DSSFQSK(gl)QTGRR_
POLD1 Ubiquitylation K447 -1.286 _DTK(gl)VVSMVGR_
POLD1 Ubiquitylation K414 -1.315 _AQTLK(gl)VQTFPFLGR_
POLD1 Ubiquitylation K853 -0.080 -1.776 _MDCK(gl)GLEAVR_
POLD1 Ubiquitylation K674 -1.082 -1.843 _TPTGDEFVK(gl)TSVR_
POLD1 Ubiquitylation K923 -2.496 _AASDYAGK(gl)QAHVELAER_
POLD1 Ubiquitylation K1065 -0.208 _ESELYQK(gl)EVSHLNALEER_

Background Information for POLD1:


Pubmed-POLD1 »
Uniprot-POLD1 »
Biogrid-POLD1 »
ProteomicsDB-POLD1 »

Tumorportal-POLD1 »
COSMIC-POLD1 »
GenomeRNAi-POLD1 »
Genecards-POLD1


Protein-protein Interactions for POLD1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CNOT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH7 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCNA Cat. description Hein, Mann, Cell 2015
Category members IP bait POLD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait USP43 Cat. description Hein, Mann, Cell 2015
Category members IP bait POLD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in POLD1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DNA-dir_DNA_pol_B_exonuc IPR006133 0
Category members DNA-dir_DNA_pol_B_multi_dom IPR006134 0
Category members DNA-dir_DNA_pol_B IPR006172 0
Category members RNaseH-like_dom IPR012337 0


Protein complexes (CORUM database) featuring POLD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1004 RC complex during S-phase of cell cycle Database 0.79
Category members Corum 1005 RC complex during G2/M-phase of cell cycle Database 0.67
Category members Corum 1098 DNA synthesome complex (13 subunits) Database 0.35
Category members Corum 1099 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 1111 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 1107 DNA synthesome core complex Database 0
Category members Corum 1108 DNA synthesome complex (15 subunits) Database 0
Category members Corum 297 PCNA-DNA polymerase delta complex Database 0


Categories featuring POLD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members Pathway Pathway_344 REACTOME_GLOBAL_GENOMIC_NER_GG_NER 0 3.29
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006271 DNA strand elongation involved in DNA replication Database 1.33
Category members Pathway Pathway_341 KEGG_MISMATCH_REPAIR 0 1.02
Category members Pathway Pathway_329 KEGG_DNA_REPLICATION 0 0.95
Category members Pathway Pathway_327 REACTOME_DNA_STRAND_ELONGATION 0 0.9
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0009411 response to UV Database 0.79
Category members GO Category GO:0000722 telomere maintenance via recombination Database 0.64
Category members GO Category GO:0006287 base-excision repair, gap-filling Database 0.48
Category members GO Category GO:0032201 telomere maintenance via semi-conservative replication Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_324 REACTOME_EXTENSION_OF_TELOMERES 0 0.33
Category members GO Category GO:0006297 nucleotide-excision repair, DNA gap filling Database 0.25
Category members Pathway Pathway_340 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND 0 0.24
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_311 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND 0 0.2
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members GO Category GO:0055089 fatty acid homeostasis Database 0.14
Category members Pathway Pathway_343 KEGG_HOMOLOGOUS_RECOMBINATION 0 0.12
Category members Pathway Pathway_316 REACTOME_LAGGING_STRAND_SYNTHESIS 0 0.11
Category members Pathway Pathway_333 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER 0 0.08
Category members GO Category GO:0006139 nucleobase-containing compound metabolic process Database 0.08
Category members GO Category GO:0000109 nucleotide-excision repair complex Database 0.06
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members Pathway Pathway_314 REACTOME_POL_SWITCHING 0 0
Category members Pathway Pathway_334 KEGG_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_335 REACTOME_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_337 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY 0 0
Category members GO Category GO:0000731 DNA synthesis involved in DNA repair Database 0
Category members GO Category GO:0003887 DNA-directed DNA polymerase activity Database 0
Category members GO Category GO:0007346 regulation of mitotic cell cycle Database 0
Category members GO Category GO:0008408 3'-5' exonuclease activity Database 0
Category members GO Category GO:0043137 DNA replication, removal of RNA primer Database 0
Category members GO Category GO:0043625 delta DNA polymerase complex Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051539 4 iron, 4 sulfur cluster binding Database 0


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