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Query: WRN

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
WRN 0 1.113 -0.320 -0.170 0.180

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
WRN Ubiquitylation K134 0.717 _MLLENKAVK(gl)_
WRN Phosphorylation S1133 0.363 0.023 _SIMVQS(ph)PEK_

Background Information for WRN:


Pubmed-WRN »
Uniprot-WRN »
Biogrid-WRN »
ProteomicsDB-WRN »

Tumorportal-WRN »
COSMIC-WRN »
GenomeRNAi-WRN »
Genecards-WRN


Protein-protein Interactions for WRN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait TINF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA0930 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SKAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XRCC6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in WRN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members DNA_helicase_ATP-dep_RecQ IPR004589 0.25
Category members HRDC-like IPR010997 0.17
Category members RQC_domain IPR018982 0.11
Category members HRDC_dom IPR002121 0
Category members 3'-5'_exonuclease_dom IPR002562 0
Category members RNaseH-like_dom IPR012337 0


Protein complexes (CORUM database) featuring WRN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5235 WRN-Ku70-Ku80-PARP1 complex Database 0.31
Category members Corum 4082 Ku70/Ku86/Werner complex Database 0.11
Category members Corum 1217 WRN-TRF2 complex Database 0


Categories featuring WRN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0003678 DNA helicase activity Database 2.22
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0032508 DNA duplex unwinding Database 1.24
Category members GO Category GO:0009378 four-way junction helicase activity Database 1.06
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0000405 bubble DNA binding Database 0.4
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Disease phenotype COLORECTAL_CANCER COLORECTAL CANCER Database 0.29
Category members GO Category GO:0043140 ATP-dependent 3'-5' DNA helicase activity Database 0.25
Category members GO Category GO:0032066 nucleolus to nucleoplasm transport Database 0.11
Category members GO Category GO:0051880 G-quadruplex DNA binding Database 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0044237 cellular metabolic process Database 0.08
Category members GO Category GO:0006139 nucleobase-containing compound metabolic process Database 0.08
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members GO Category GO:0000403 Y-form DNA binding Database 0.04
Category members GO Category GO:0009267 cellular response to starvation Database 0.03
Category members GO Category GO:0007569 cell aging Database 0.03
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0000731 DNA synthesis involved in DNA repair Database 0
Category members GO Category GO:0001302 replicative cell aging Database 0
Category members GO Category GO:0004527 exonuclease activity Database 0
Category members GO Category GO:0006259 DNA metabolic process Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0008408 3'-5' exonuclease activity Database 0
Category members GO Category GO:0010225 response to UV-C Database 0
Category members GO Category GO:0010259 multicellular organismal aging Database 0
Category members GO Category GO:0030145 manganese ion binding Database 0
Category members GO Category GO:0031297 replication fork processing Database 0
Category members GO Category GO:0032389 MutLalpha complex Database 0
Category members GO Category GO:0040009 regulation of growth rate Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043138 3'-5' DNA helicase activity Database 0
Category members GO Category GO:0051345 positive regulation of hydrolase activity Database 0


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