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Query: EXOSC10

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EXOSC10 0 -2.320 0.160 -0.170 -0.327 -0.108 -0.734 -0.003

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EXOSC10 Ubiquitylation K591 -1.148 _SEVAAGVK(gl)K_
EXOSC10 Ubiquitylation K592 -1.148 _SEVAAGVK(gl)K_
EXOSC10 Ubiquitylation K710 -1.867 _APVSQAAK(gl)FDPSTK_
EXOSC10 Ubiquitylation K680 -1.926 _GPLTVAQKK(gl)_
EXOSC10 Ubiquitylation K716 -2.215 _FDPSTK(gl)IYEISNR_

Background Information for EXOSC10:


Pubmed-EXOSC10 »
Uniprot-EXOSC10 »
Biogrid-EXOSC10 »
ProteomicsDB-EXOSC10 »

Tumorportal-EXOSC10 »
COSMIC-EXOSC10 »
GenomeRNAi-EXOSC10 »
Genecards-EXOSC10


Protein-protein Interactions for EXOSC10
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DIS3L Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC1;RP11 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC9 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RBM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL18A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZC3H18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EXOSC10
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HRDC-like IPR010997 0.17
Category members HRDC_dom IPR002121 0
Category members 3'-5'_exonuclease_dom IPR002562 0
Category members RNaseH-like_dom IPR012337 0


Protein complexes (CORUM database) featuring EXOSC10
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 822 mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN) Database 1.39
Category members Corum 789 Exosome Database 0.83


Categories featuring EXOSC10
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Database INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0000178 exosome (RNase complex) Database 0.78
Category members GO Category GO:0071034 CUT catabolic process Database 0.53
Category members GO Category GO:0071044 histone mRNA catabolic process Database 0.35
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0000176 nuclear exosome (RNase complex) Database 0.29
Category members GO Category GO:0000460 maturation of 5.8S rRNA Database 0.29
Category members Pathway Pathway_310 KEGG_RNA_DEGRADATION 0 0.26
Category members GO Category GO:0004532 exoribonuclease activity Database 0.26
Category members GO Category GO:0071028 nuclear mRNA surveillance Database 0.19
Category members GO Category GO:0006396 RNA processing Database 0.17
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0044237 cellular metabolic process Database 0.08
Category members GO Category GO:0006139 nucleobase-containing compound metabolic process Database 0.08
Category members GO Category GO:0000956 nuclear-transcribed mRNA catabolic process Database 0.04
Category members GO Category GO:0035327 transcriptionally active chromatin Database 0.04
Category members GO Category GO:0008408 3'-5' exonuclease activity Database 0
Category members GO Category GO:0009048 dosage compensation by inactivation of X chromosome Database 0
Category members GO Category GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process Database 0


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