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Query: RAD50

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RAD50 3 10.639 0.350 -0.420 0.165 0.571 0.509 0.691 0.587

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RAD50 Phosphorylation S635 2.474 3.050 _LFDVCGS(ph)QDFESDLDR_
RAD50 Ubiquitylation K753 0.394 0.397 _NK(gl)LQNVNR_
RAD50 Ubiquitylation K62 -1.069 _YICTGDFPPGTK(gl)GNTFVHDPK_
RAD50 Ubiquitylation K933 0.397 _FQQEKEELINKK(gl)_
RAD50 Ubiquitylation K1068 0.098 _LEENIDNIK(gl)R_
RAD50 Ubiquitylation K1178 -0.548 _SDADENVSASDK(gl)RR_
RAD50 Ubiquitylation K1285 2.195 _SEYVEK(gl)FYR_

Background Information for RAD50:


Pubmed-RAD50 »
Uniprot-RAD50 »
Biogrid-RAD50 »
ProteomicsDB-RAD50 »

Tumorportal-RAD50 »
COSMIC-RAD50 »
GenomeRNAi-RAD50 »
Genecards-RAD50


Protein-protein Interactions for RAD50
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FGFR1OP Cat. description Hein, Mann, Cell 2015
Category members IP bait HSF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF13B Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF1B Cat. description Hein, Mann, Cell 2015
Category members IP bait MAX Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP188 Cat. description Hein, Mann, Cell 2015
Category members IP bait RASSF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SIDT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC33A1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM132A Cat. description Hein, Mann, Cell 2015
Category members IP bait TRIP11 Cat. description Hein, Mann, Cell 2015
Category members IP bait ATG14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BMP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C9orf25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CELA2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM196A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HS1BP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC39 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB39B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RGS20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFAND2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF511 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RAD50
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Prefoldin IPR009053 0


Protein complexes (CORUM database) featuring RAD50
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1193 Rap1 complex Database 2.66
Category members Corum 1189 DNA double-strand break end-joining complex Database 2.16
Category members Corum 433 BASC complex (BRCA1-associated genome surveillance complex) Database 1.74
Category members Corum 3135 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.58
Category members Corum 2815 BRCA1-BARD1-BACH1-DNA damage complex II Database 1.57
Category members Corum 2766 TERF2-RAP1 complex Database 1.52
Category members Corum 202 BRCA1-RAD50-MRE11-NBS1 complex Database 1.09
Category members Corum 2218 MDC1-MRE11-RAD50-NBS1 complex Database 1.09
Category members Corum 619 MRE11A-RAD50-NBN-TRF2 complex Database 1.09
Category members Corum 627 MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) Database 1.09
Category members Corum 964 BRCA1-RAD50-MRE11-NBS1 complex Database 1.09
Category members Corum 2217 MDC1-MRN-ATM-FANCD2 complex Database 1.08
Category members Corum 1729 TLE1 corepressor complex (MASH1 promoter-corepressor complex) Database 1.02
Category members Corum 5197 PTIP-DNA damage response complex Database 0.94
Category members Corum 436 BASC (Ab C-20) complex (BRCA1-associated genome surveillance complex) Database 0.88
Category members Corum 1081 MRN complex (MRE11-RAD50-NBN complex) Database 0.62
Category members Corum 173 MRN complex (MRE11-RAD50-NBN complex) Database 0.62
Category members Corum 2767 RAD50-MRE11-NBN-p200-p350 complex Database 0.62
Category members Corum 331 MRN complex (MRE11-RAD50-NBN complex) Database 0.62
Category members Corum 618 MRN complex (MRE11-RAD50-NBN complex) Database 0.62
Category members Corum 71 MRN complex (MRE11-RAD50-NBS1 complex) Database 0.62
Category members Corum 73 MRN complex (MRE11-RAD50-NBN complex) Database 0.62
Category members Corum 972 MRN complex (MRE11-RAD50-NBS1 complex) Database 0.62
Category members Corum 2776 RAD50-BRCA1 complex Database 0.37
Category members Corum 263 R/M complex (RAD50-MRE11 complex) Database 0.25
Category members Corum 264 R/M complex (RAD50-MRE11 complex) Database 0.25
Category members Corum 72 R/M complex (RAD50-MRE11 complex) Database 0.25
Category members Corum 1204 Rap1 complex Database 0.04


Categories featuring RAD50
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members Pathway Pathway_861 REACTOME_DOUBLE_STRAND_BREAK_REPAIR 0 4.5
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members Pathway Pathway_874 REACTOME_MEIOTIC_RECOMBINATION 0 3.7
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members Pathway Pathway_862 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS 0 3
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members GO Category GO:0030870 Mre11 complex Database 1.75
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0032508 DNA duplex unwinding Database 1.24
Category members Disease phenotype Hereditary_breast_and_ovarian_cancer_syndrome Hereditary breast and ovarian cancer syndrome Database 1.23
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members GO Category GO:0007004 telomere maintenance via telomerase Database 0.98
Category members GO Category GO:0035861 site of double-strand break Database 0.65
Category members GO Category GO:0000784 nuclear chromosome, telomeric region Database 0.61
Category members Pathway Pathway_979 BIOCARTA_ATRBRCA_PATHWAY 0 0.6
Category members Pathway Pathway_860 KEGG_NON_HOMOLOGOUS_END_JOINING 0 0.52
Category members Pathway Pathway_980 BIOCARTA_ATM_PATHWAY 0 0.46
Category members GO Category GO:0033674 positive regulation of kinase activity Database 0.3
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0045120 pronucleus Database 0.27
Category members GO Category GO:0000019 regulation of mitotic recombination Database 0.25
Category members GO Category GO:0030674 protein binding, bridging Database 0.25
Category members GO Category GO:0000014 single-stranded DNA endodeoxyribonuclease activity Database 0.23
Category members Pathway Pathway_343 KEGG_HOMOLOGOUS_RECOMBINATION 0 0.12
Category members GO Category GO:0004518 nuclease activity Database 0.09
Category members GO Category GO:0007131 reciprocal meiotic recombination Database 0
Category members GO Category GO:0008408 3'-5' exonuclease activity Database 0
Category members GO Category GO:0031954 positive regulation of protein autophosphorylation Database 0


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