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Query: APEX1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
APEX1 0 -0.349 0.630 -0.180 -0.057 -0.077

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
APEX1 Ubiquitylation K25 -0.227 _GAVAEDGDELRTEPEAKK(gl)_
APEX1 Ubiquitylation K58 -0.215 _TSPSGK(gl)PATLK_

Background Information for APEX1:


Pubmed-APEX1 »
Uniprot-APEX1 »
Biogrid-APEX1 »
ProteomicsDB-APEX1 »

Tumorportal-APEX1 »
COSMIC-APEX1 »
GenomeRNAi-APEX1 »
Genecards-APEX1


Protein-protein Interactions for APEX1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APEX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCGR2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in APEX1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members AP_endonuc_1 IPR004808 0
Category members Endo/exonuclease/phosphatase IPR005135 0


Protein complexes (CORUM database) featuring APEX1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2808 RAD9-RAD1-HUS1-APE1 complex Database 0.01
Category members Corum 298 VEGF transcriptional complex Database 0


Categories featuring APEX1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005840 ribosome Database 12.2
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0051059 NF-kappaB binding Database 0.25
Category members Pathway Pathway_762 PID_HIF2PATHWAY 0 0.23
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity Database 0.16
Category members GO Category GO:0004518 nuclease activity Database 0.09
Category members GO Category GO:0043488 regulation of mRNA stability Database 0.07
Category members GO Category GO:0004844 uracil DNA N-glycosylase activity Database 0.05
Category members GO Category GO:0045454 cell redox homeostasis Database 0.05
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members Pathway Pathway_291 BIOCARTA_SET_PATHWAY 0 0.04
Category members GO Category GO:0045739 positive regulation of DNA repair Database 0.04
Category members GO Category GO:0004528 phosphodiesterase I activity Database 0.03
Category members GO Category GO:0010243 response to organonitrogen compound Database 0.02
Category members GO Category GO:0070301 cellular response to hydrogen peroxide Database 0
Category members Pathway Pathway_334 KEGG_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_335 REACTOME_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_337 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY 0 0
Category members Pathway Pathway_951 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY 0 0
Category members Pathway Pathway_952 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY 0 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0004519 endonuclease activity Database 0
Category members GO Category GO:0004520 endodeoxyribonuclease activity Database 0
Category members GO Category GO:0004521 endoribonuclease activity Database 0
Category members GO Category GO:0004523 ribonuclease H activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0008081 phosphoric diester hydrolase activity Database 0
Category members GO Category GO:0008408 3'-5' exonuclease activity Database 0
Category members GO Category GO:0014912 negative regulation of smooth muscle cell migration Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base Database 0
Category members GO Category GO:0031490 chromatin DNA binding Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0071320 cellular response to cAMP Database 0
Category members GO Category GO:0071375 cellular response to peptide hormone stimulus Database 0
Category members GO Category GO:0071417 cellular response to organonitrogen compound Database 0


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