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Query: XRCC3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
XRCC3 0 -0.644 0.420 -0.620

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
XRCC3 Ubiquitylation K36 -0.644 _EVLHFSGPDLK(gl)R_
XRCC3 Ubiquitylation K72 -0.839 _GSSILTALQLHQQK(gl)ER_
XRCC3 Ubiquitylation K17 -1.225 _IIAAIK(gl)K_

Background Information for XRCC3:


Pubmed-XRCC3 »
Uniprot-XRCC3 »
Biogrid-XRCC3 »
ProteomicsDB-XRCC3 »

Tumorportal-XRCC3 »
COSMIC-XRCC3 »
GenomeRNAi-XRCC3 »
Genecards-XRCC3


Protein-protein Interactions for XRCC3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait C1orf85 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM196A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR77 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL13RA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ISLR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LAMP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LAMP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLAUR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TOMM22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TOR1AIP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPSB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in XRCC3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members DNA_recomb/repair_RecA-like IPR016467 0.04
Category members DNA_recomb/repair_Rad51_C IPR013632 0
Category members RecA_ATP-bd IPR020588 0


Protein complexes (CORUM database) featuring XRCC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1196 RAD51C-XRCC3 complex Database 0.28
Category members Corum 252 RAD51C-XRCC3 complex Database 0.28
Category members Corum 253 RAD51C-XRCC3 complex Database 0.28
Category members Corum 259 RAD51C-XRCC3 complex Database 0.28
Category members Corum 261 RAD51B-RAD51C-RAD51D-XRCC2-XRCC3 complex Database 0


Categories featuring XRCC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0008094 DNA-dependent ATPase activity Database 2.31
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members Disease phenotype BREAST_CANCER BREAST CANCER Database 0.62
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_343 KEGG_HOMOLOGOUS_RECOMBINATION 0 0.12
Category members GO Category GO:0006259 DNA metabolic process Database 0
Category members GO Category GO:0010033 response to organic substance Database 0


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