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Query: TOP3A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TOP3A 1 1.553 2.070 -0.580 0.498 0.705
TOP3A 1 1.553 2.070 -0.580 -0.370 0.720

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for TOP3A:


Pubmed-TOP3A »
Uniprot-TOP3A »
Biogrid-TOP3A »
ProteomicsDB-TOP3A »

Tumorportal-TOP3A »
COSMIC-TOP3A »
GenomeRNAi-TOP3A »
Genecards-TOP3A


Protein-protein Interactions for TOP3A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BLM Cat. description Hein, Mann, Cell 2015
Category members IP bait ATP5D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BPNT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C16orf75 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C17orf90 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C4orf26 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC69 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COX7A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ECHDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LIG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MARCKSL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MECP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait METTL2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPL21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NIT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RMI1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDHB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLX1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait THEM4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YBEY Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TOP3A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_CCHC IPR001878 1.51
Category members Topo_IA IPR000380 0.05
Category members Topo_IA_2 IPR003601 0.05
Category members Topo_IA_DNA-bd_dom IPR003602 0.05
Category members Toprim_domain IPR006171 0.05
Category members Topo_IA_cen IPR013497 0.05
Category members Topo_IA_core_domain IPR023405 0.05
Category members Znf_GRF IPR010666 0


Protein complexes (CORUM database) featuring TOP3A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2222 BLM complex II Database 0.3
Category members Corum 2738 BLM complex II Database 0.3
Category members Corum 244 BRAFT complex Database 0.29
Category members Corum 248 BRAFT complex Database 0.27
Category members Corum 2223 BLM-TOP3A complex Database 0.05
Category members Corum 246 BLM complex III Database 0.01
Category members Corum 2739 FA complex (Fanconi anemia complex) Database 0


Categories featuring TOP3A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members GO Category GO:0005694 chromosome Database 3.87
Category members Pathway Pathway_874 REACTOME_MEIOTIC_RECOMBINATION 0 3.7
Category members GO Category GO:0006265 DNA topological change Database 1.92
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0016605 PML body Database 1.41
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0003917 DNA topoisomerase type I activity Database 0.39
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members Pathway Pathway_343 KEGG_HOMOLOGOUS_RECOMBINATION 0 0.12
Category members GO Category GO:0003916 DNA topoisomerase activity Database 0.05
Category members GO Category GO:0007126 meiosis Database 0.01


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