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Query: TOPBP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TOPBP1 3 8.153 -2.480 4.260 -0.269 0.277

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TOPBP1 Phosphorylation S888 2.918 1.917 _NAVALSAS(ph)PQLK_
TOPBP1 Ubiquitylation K789 -0.950 _FQSK(gl)AFR_

Background Information for TOPBP1:


Pubmed-TOPBP1 »
Uniprot-TOPBP1 »
Biogrid-TOPBP1 »
ProteomicsDB-TOPBP1 »

Tumorportal-TOPBP1 »
COSMIC-TOPBP1 »
GenomeRNAi-TOPBP1 »
Genecards-TOPBP1


Protein-protein Interactions for TOPBP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TOPBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CBLN4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDO1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TOPBP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members BRCT_dom IPR001357 1.59
Category members Secretoglobin IPR016126 0


Protein complexes (CORUM database) featuring TOPBP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2815 BRCA1-BARD1-BACH1-DNA damage complex II Database 1.57
Category members Corum 2817 BRCA1-BARD1-BACH1-DNA damage complex I Database 0.79


Categories featuring TOPBP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_865 PID_ATR_PATHWAY 0 3.46
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members GO Category GO:0010212 response to ionizing radiation Database 1.66
Category members GO Category GO:0000794 condensed nuclear chromosome Database 1.58
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0016605 PML body Database 1.41
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0001673 male germ cell nucleus Database 0.44
Category members GO Category GO:0005815 microtubule organizing center Database 0.39
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0006259 DNA metabolic process Database 0


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