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Query: CHEK2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CHEK2 2 6.476 0.530 0.100

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CHEK2 Phosphorylation S260 3.670 3.632 _KFAIGS(ph)AR_
CHEK2 Ubiquitylation K437 -0.826 _TQVSLK(gl)DQITSGK_

Background Information for CHEK2:


Pubmed-CHEK2 »
Uniprot-CHEK2 »
Biogrid-CHEK2 »
ProteomicsDB-CHEK2 »

Tumorportal-CHEK2 »
COSMIC-CHEK2 »
GenomeRNAi-CHEK2 »
Genecards-CHEK2


Protein-protein Interactions for CHEK2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait RAB11A Cat. description Hein, Mann, Cell 2015
Category members IP bait TEX264 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TP63 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CHEK2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members FHA_dom IPR000253 2.3
Category members SMAD_FHA_domain IPR008984 0.86
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring CHEK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2236 ASF1-histone containing complex Database 0.04


Categories featuring CHEK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0000077 DNA damage checkpoint Database 2.04
Category members Pathway Pathway_798 REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT 0 1.64
Category members GO Category GO:0016605 PML body Database 1.41
Category members Disease phenotype Hereditary_breast_and_ovarian_cancer_syndrome Hereditary breast and ovarian cancer syndrome Database 1.23
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0042176 regulation of protein catabolic process Database 0.91
Category members Pathway Pathway_968 PID_FOXM1_PATHWAY 0 0.8
Category members Pathway Pathway_863 REACTOME_G2_M_CHECKPOINTS 0 0.74
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members Disease phenotype BREAST_CANCER BREAST CANCER Database 0.62
Category members Pathway Pathway_979 BIOCARTA_ATRBRCA_PATHWAY 0 0.6
Category members GO Category GO:0010332 response to gamma radiation Database 0.52
Category members Pathway Pathway_980 BIOCARTA_ATM_PATHWAY 0 0.46
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0042770 signal transduction in response to DNA damage Database 0.35
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members Pathway Pathway_982 BIOCARTA_G2_PATHWAY 0 0.24
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members Pathway Pathway_1248 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT 0 0.21
Category members Disease phenotype OSTEOGENIC_SARCOMA OSTEOGENIC SARCOMA Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0000781 chromosome, telomeric region Database 0.16
Category members Disease phenotype Familial_prostate_cancer Familial prostate cancer Database 0.07
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Disease phenotype Li-Fraumeni_syndrome Li-Fraumeni syndrome Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Disease phenotype PROSTATE_CANCER PROSTATE CANCER Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006975 DNA damage induced protein phosphorylation Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0044257 cellular protein catabolic process Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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