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Query: PRKDC

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRKDC 3 6.094 1.430 -1.280 -0.994 -0.672 -0.244 0.307 0.443

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRKDC Phosphorylation S2612 -0.226 1.740 _STVLTPMFVETQAS(ph)QGTLQTR_
PRKDC Phosphorylation S3205 2.096 1.572 _LTPLPEDNS(ph)M(ox)NVDQDGDPSDR_
PRKDC Ubiquitylation K357 1.479 _NVDSNNK(gl)ELSIAIR_
PRKDC Ubiquitylation K3608 1.045 1.399 _NIEK(gl)MYER_
PRKDC Ubiquitylation K838 1.939 1.087 _TK(gl)NLSSNEAISLEEIR_
PRKDC Ubiquitylation K163 0.679 _FYGELALK(gl)K_
PRKDC Ubiquitylation K1038 0.646 _EFLK(gl)WSIK_
PRKDC Ubiquitylation K117 0.540 0.376 _NTCTSVYTK(gl)DR_
PRKDC Ubiquitylation K810 0.561 0.360 _TSALSDETK(gl)NNWEVSALSR_
PRKDC Ubiquitylation K3552 1.164 0.277 _NK(gl)EFVAR_
PRKDC Ubiquitylation K3235 0.810 0.153 _SCK(gl)FSMK_
PRKDC Ubiquitylation K1334 0.108 _YNYSK(gl)CTVVVR_
PRKDC Phosphorylation S2672 0.083 _SSFDWLTGSSTDPLVDHTS(ph)PSSDSLLFAHK_
PRKDC Phosphorylation S2677 0.284 -0.009 _SSFDWLTGSSTDPLVDHTSPSSDS(ph)LLFAHK_
PRKDC Ubiquitylation K108 0.568 -0.049 _IAPYSVEIK(gl)NTCTSVYTK_
PRKDC Ubiquitylation K1857 -0.152 _FTK(gl)LNESTFDTQITK_
PRKDC Ubiquitylation K689 -0.187 _YFEGVSPK(gl)SLK_
PRKDC Phosphorylation S2675 -0.193 _SSFDWLTGSSTDPLVDHTSPSS(ph)DSLLFAHK_
PRKDC Ubiquitylation K828 0.723 -0.203 _GFNK(gl)VVLK_
PRKDC Ubiquitylation K1744 -0.269 _FNNYVDCMK(gl)K_
PRKDC Ubiquitylation K832 1.611 -0.278 _VVLK(gl)HLK_
PRKDC Ubiquitylation K3248 0.977 -0.289 _K(gl)QNNFSLAMK_
PRKDC Ubiquitylation K2928 0.416 -0.319 _WVELAK(gl)LYR_
PRKDC Ubiquitylation K374 -0.342 _GYGLFAGPCK(gl)VINAK_
PRKDC Ubiquitylation K2738 -0.251 -0.421 _DQEK(gl)LSLMYAR_
PRKDC Ubiquitylation K1042 -0.070 -0.432 _WSIK(gl)QITPQQQEK_
PRKDC Ubiquitylation K2764 0.293 -0.445 _MK(gl)QDAQVVLYR_
PRKDC Ubiquitylation K4023 -0.481 _K(gl)GGSWIQEINVAEK_
PRKDC Ubiquitylation K1456 0.657 -0.495 _LAAVVSACK(gl)QLHR_
PRKDC Ubiquitylation K2418 -0.499 _SK(gl)DFVQVMR_
PRKDC Ubiquitylation K3650 0.475 -0.515 _GGSK(gl)LLR_
PRKDC Ubiquitylation K3241 0.107 -0.523 _MK(gl)MIDSAR_
PRKDC Ubiquitylation K1870 0.843 -0.566 _LNESTFDTQITKK(gl)_
PRKDC Ubiquitylation K493 -0.582 _ICSK(gl)PVVLPK_
PRKDC Ubiquitylation K3455 0.488 -0.615 _ALK(gl)LNSNEAR_
PRKDC Ubiquitylation K263 0.272 -0.659 _AIRPQIDLK(gl)R_
PRKDC Ubiquitylation K1057 -0.693 _SPVNTK(gl)SLFK_
PRKDC Ubiquitylation K4019 -0.937 _NFEQK(gl)MLK_
PRKDC Ubiquitylation K3710 0.119 -0.965 _GK(gl)PLPEYHVR_
PRKDC Ubiquitylation K1407 -0.971 _ALK(gl)MSPYK_
PRKDC Ubiquitylation K3631 -1.002 _K(gl)FIQTFGK_
PRKDC Ubiquitylation K2447 -0.500 -1.069 _LK(gl)PVELR_
PRKDC Ubiquitylation K2829 -1.122 _TLSEK(gl)NNITQK_
PRKDC Ubiquitylation K1051 -1.153 _QITPQQQEK(gl)SPVNTK_
PRKDC Ubiquitylation K963 -1.201 _ATQMPEGGQGAPPMYQLYK(gl)R_
PRKDC Ubiquitylation K3884 -0.255 -1.203 _VPADLLK(gl)R_
PRKDC Ubiquitylation K3260 0.018 -1.258 _LLK(gl)ELHK_
PRKDC Ubiquitylation K3158 0.005 -1.352 _QGNLSSQVPLK(gl)R_
PRKDC Ubiquitylation K2715 0.258 -1.356 _LGLPGDEVDNK(gl)VK_
PRKDC Ubiquitylation K1892 -1.132 -1.666 _LPKDDVHAK(gl)ESK_
PRKDC Ubiquitylation K2908 -0.765 -1.790 _LLPAELPAK(gl)R_
PRKDC Ubiquitylation K2717 -1.795 _LGLPGDEVDNKVK(gl)GAAGR_
PRKDC Ubiquitylation K2694 -1.865 _APLK(gl)SVGPDFGKK_
PRKDC Ubiquitylation K3877 0.018 -2.000 _ESK(gl)VPADLLKR_
PRKDC Ubiquitylation K164 -0.371 _FYGELALKK(gl)_
PRKDC Ubiquitylation K1869 0.803 _LNESTFDTQITK(gl)K_
PRKDC Phosphorylation T2671 -0.097 _SSFDWLTGSSTDPLVDHT(ph)SPSSDSLLFAHK_
PRKDC Ubiquitylation K2703 0.600 _SVGPDFGKK(gl)_
PRKDC Ubiquitylation K2758 -0.370 _EKEIK(gl)SELK_
PRKDC Ubiquitylation K3192 -0.192 _CFFLSK(gl)IEEK_

Background Information for PRKDC:


Pubmed-PRKDC »
Uniprot-PRKDC »
Biogrid-PRKDC »
ProteomicsDB-PRKDC »

Tumorportal-PRKDC »
COSMIC-PRKDC »
GenomeRNAi-PRKDC »
Genecards-PRKDC


Protein-protein Interactions for PRKDC
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DCLRE1B Cat. description Hein, Mann, Cell 2015
Category members IP bait DNAJC7 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait POT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP6C Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP6R1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RUVBL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RUVBL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TERF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TINF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait EPHA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPAR4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP6R2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRKDC
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members PI3/4_kinase_cat_dom IPR000403 1.52
Category members FATC IPR003152 0.68
Category members PIK_FAT IPR014009 0.68
Category members PIK-rel_kinase_FAT IPR003151 0.16
Category members Kinase-like_dom IPR011009 0.03


Protein complexes (CORUM database) featuring PRKDC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1183 CDC5L complex Database 2.07
Category members Corum 5176 MGC1-DNA-PKcs-Ku complex Database 1.21
Category members Corum 5183 DNA-PK-Ku-eIF2-NF90-NF45 complex Database 0.83
Category members Corum 5179 NCOA6-DNA-PK-Ku-PARP1 complex Database 0.7
Category members Corum 322 DNA-PK-Ku complex Database 0.68
Category members Corum 355 DNA-PK-Ku antigen complex Database 0.68
Category members Corum 356 DNA-PK-Ku antigen complex Database 0.68
Category members Corum 357 DNA-PK-Ku antigen complex Database 0.68
Category members Corum 5182 DNA-PK-Ku complex Database 0.68
Category members Corum 3102 DHX9-ADAR-vigilin-DNA-PK-Ku antigen complex Database 0.44
Category members Corum 1571 Vigilin-DNA-PK-Ku antigen complex Database 0.31
Category members Corum 360 Artemis-DNA-PK complex Database 0
Category members Corum 361 Artemis-DNA-PK complex Database 0


Categories featuring PRKDC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005488 binding Database 9.32
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members Pathway Pathway_861 REACTOME_DOUBLE_STRAND_BREAK_REPAIR 0 4.5
Category members Pathway Pathway_934 PID_PI3KCI_AKT_PATHWAY 0 2.5
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_962 BIOCARTA_FAS_PATHWAY 0 1.75
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members GO Category GO:0006303 double-strand break repair via nonhomologous end joining Database 0.79
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0070419 nonhomologous end joining complex Database 0.65
Category members GO Category GO:0032869 cellular response to insulin stimulus Database 0.63
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members GO Category GO:0032481 positive regulation of type I interferon production Database 0.54
Category members Pathway Pathway_860 KEGG_NON_HOMOLOGOUS_END_JOINING 0 0.52
Category members GO Category GO:0010332 response to gamma radiation Database 0.52
Category members GO Category GO:0033152 immunoglobulin V(D)J recombination Database 0.46
Category members Pathway Pathway_963 BIOCARTA_TNFR1_PATHWAY 0 0.44
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Pathway Pathway_982 BIOCARTA_G2_PATHWAY 0 0.24
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members Pathway Pathway_960 BIOCARTA_HIVNEF_PATHWAY 0 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex Database 0.05
Category members Pathway Pathway_967 PID_DNA_PK_PATHWAY 0 0.04
Category members GO Category GO:0002326 B cell lineage commitment Database 0.04
Category members GO Category GO:0033077 T cell differentiation in thymus Database 0.03
Category members GO Category GO:0001756 somitogenesis Database 0
Category members GO Category GO:0002328 pro-B cell differentiation Database 0
Category members GO Category GO:0002360 T cell lineage commitment Database 0
Category members GO Category GO:0004677 DNA-dependent protein kinase activity Database 0
Category members GO Category GO:0006464 cellular protein modification process Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0016773 phosphotransferase activity, alcohol group as acceptor Database 0
Category members GO Category GO:0030098 lymphocyte differentiation Database 0
Category members GO Category GO:0031648 protein destabilization Database 0
Category members GO Category GO:0033153 T cell receptor V(D)J recombination Database 0
Category members GO Category GO:0035234 germ cell programmed cell death Database 0


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