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Query: MSH2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MSH2 1 6.642 -0.130 0.010 0.224 0.457 0.838 0.840 0.366

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MSH2 Ubiquitylation K347 2.867 _LVNQWIK(gl)QPLMDK_
MSH2 Ubiquitylation K555 0.164 _FTNSK(gl)LTSLNEEYTK_
MSH2 Ubiquitylation K212 -0.233 _ECVLPGGETAGDMGK(gl)LR_
MSH2 Ubiquitylation K635 -0.376 _IILK(gl)ASR_
MSH2 Ubiquitylation K249 0.461 _K(gl)GEQMNSAVLPEMENQVAVSSLSAVIK_
MSH2 Ubiquitylation K531 1.040 _VTCKEEK(gl)VLR_

Background Information for MSH2:


Pubmed-MSH2 »
Uniprot-MSH2 »
Biogrid-MSH2 »
ProteomicsDB-MSH2 »

Tumorportal-MSH2 »
COSMIC-MSH2 »
GenomeRNAi-MSH2 »
Genecards-MSH2


Protein-protein Interactions for MSH2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MSH6 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCNA Cat. description Hein, Mann, Cell 2015


Protein Domains in MSH2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members DNA_mismatch_repair_MutS-lik_N IPR007695 0.43
Category members DNA_mmatch_repair_MutS_con_dom IPR007860 0.43
Category members DNA_mismatch_repair_MutS_C IPR000432 0.16
Category members DNA_mismatch_repair_MutS_core IPR007696 0.16
Category members DNA_mismatch_repair_MutS_clamp IPR007861 0.16


Protein complexes (CORUM database) featuring MSH2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1335 SNW1 complex Database 3.59
Category members Corum 433 BASC complex (BRCA1-associated genome surveillance complex) Database 1.74
Category members Corum 286 PCNA-MSH2-MSH6 complex Database 0.88
Category members Corum 289 PCNA-MSH2-MSH6 complex Database 0.88
Category members Corum 377 PCNA-MutS-alpha-DNA initial complex Database 0.88
Category members Corum 434 BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) Database 0.83
Category members Corum 376 PCNA-MutS-alpha-MutL-alpha-DNA complex Database 0.43
Category members Corum 1078 MSH2-MSH6 complex Database 0.35
Category members Corum 2740 MutS-alpha complex Database 0.35
Category members Corum 374 MSH2-MSH6 complex Database 0.35
Category members Corum 368 ERCC1-ERCC4-MSH2 complex Database 0.29
Category members Corum 290 MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex Database 0.18
Category members Corum 369 MSH2-MSH6-PMS2-MLH1 complex Database 0.18
Category members Corum 370 MSH2-MSH6-PMS1-MLH1 complex Database 0.18
Category members Corum 431 MSH2-MSH6-PMS2-MLH1 complex Database 0.18
Category members Corum 375 MSH2-MSH3 complex Database 0.17
Category members Corum 378 MutS-beta complex Database 0.17
Category members Corum 2226 MutS-alpha-PK-zeta complex Database 0.13
Category members Corum 438 GCN5-TRRAP histone acetyltransferase complex Database 0.05
Category members Corum 2224 MSH2/6-BLM-p53-RAD51 complex Database 0
Category members Corum 291 MSH2-MLH1-PMS2 DNA-repair initiation complex Database 0


Categories featuring MSH2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members DDR Literature pubmedid:24055347 Jungmichel et al., 2013 UV-stimulated poly(ADP-Ribosyl)ation targets Jungmichel et al., 2013 INF
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0008094 DNA-dependent ATPase activity Database 2.31
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0032405 MutLalpha complex binding Database 1.47
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0031573 intra-S DNA damage checkpoint Database 1.18
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members Pathway Pathway_341 KEGG_MISMATCH_REPAIR 0 1.02
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0000228 nuclear chromosome Database 0.89
Category members GO Category GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Database 0.83
Category members GO Category GO:0051096 positive regulation of helicase activity Database 0.73
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0000710 meiotic mismatch repair Database 0.54
Category members Disease phenotype MUIR-TORRE_SYNDROME MUIR-TORRE SYNDROME Database 0.46
Category members GO Category GO:0032137 guanine/thymine mispair binding Database 0.46
Category members GO Category GO:0010224 response to UV-B Database 0.44
Category members GO Category GO:0000404 loop DNA binding Database 0.43
Category members GO Category GO:0032139 dinucleotide insertion or deletion binding Database 0.43
Category members GO Category GO:0032142 single guanine insertion binding Database 0.43
Category members GO Category GO:0032357 oxidized purine DNA binding Database 0.43
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0032143 single thymine insertion binding Database 0.35
Category members GO Category GO:0032301 MutSalpha complex Database 0.35
Category members GO Category GO:0006298 mismatch repair Database 0.33
Category members GO Category GO:0010165 response to X-ray Database 0.32
Category members GO Category GO:0045910 negative regulation of DNA recombination Database 0.31
Category members GO Category GO:0030983 mismatched DNA binding Database 0.27
Category members GO Category GO:0043531 ADP binding Database 0.27
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0019237 centromeric DNA binding Database 0.23
Category members Disease phenotype ENDOMETRIAL_CANCER ENDOMETRIAL CANCER Database 0.21
Category members GO Category GO:0016447 somatic recombination of immunoglobulin gene segments Database 0.21
Category members GO Category GO:0000400 four-way junction DNA binding Database 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0002204 somatic recombination of immunoglobulin genes involved in immune response Database 0.18
Category members Disease phenotype Constitutional_mismatch_repair_deficiency_syndrome Constitutional mismatch repair deficiency syndrome Database 0.18
Category members Disease phenotype Nonpolyposis_Turcot_syndrome Nonpolyposis Turcot syndrome Database 0.18
Category members GO Category GO:0000406 double-strand/single-strand DNA junction binding Database 0.17
Category members GO Category GO:0032181 dinucleotide repeat insertion binding Database 0.17
Category members GO Category GO:0032302 MutSbeta complex Database 0.17
Category members Disease phenotype Hereditary_nonpolyposis_colon_cancer Hereditary nonpolyposis colon cancer Database 0.14
Category members GO Category GO:0045190 isotype switching Database 0.11
Category members GO Category GO:0006311 meiotic gene conversion Database 0.08
Category members GO Category GO:0008340 determination of adult lifespan Database 0.05
Category members GO Category GO:0000403 Y-form DNA binding Database 0.04
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0006119 oxidative phosphorylation Database 0
Category members GO Category GO:0006301 postreplication repair Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007281 germ cell development Database 0
Category members GO Category GO:0008584 male gonad development Database 0
Category members GO Category GO:0016446 somatic hypermutation of immunoglobulin genes Database 0
Category members GO Category GO:0019724 B cell mediated immunity Database 0
Category members GO Category GO:0030183 B cell differentiation Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043570 maintenance of DNA repeat elements Database 0


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