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Query: TOPORS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TOPORS 0 0.214 0.090 -0.190

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TOPORS Ubiquitylation K249 -0.396 0.347 _K(gl)IQEQDIINFRR_
TOPORS Phosphorylation S585 0.204 0.058 _VYS(ph)PYNHR_
TOPORS Phosphorylation S98 -0.529 -0.409 _LQQTVPADAS(ph)PDSK_
TOPORS Ubiquitylation K83 -0.537 -0.928 _MDNFSPK(gl)AGTSK_
TOPORS Ubiquitylation K73 -2.412 _ELAASAPARPAPASSEIMASAAK(gl)EFK_
TOPORS Ubiquitylation K76 -2.551 _EFK(gl)MDNFSPK_

Background Information for TOPORS:


Pubmed-TOPORS »
Uniprot-TOPORS »
Biogrid-TOPORS »
ProteomicsDB-TOPORS »

Tumorportal-TOPORS »
COSMIC-TOPORS »
GenomeRNAi-TOPORS »
Genecards-TOPORS


Protein-protein Interactions for TOPORS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PQBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LLGL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MKI67IP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NKAP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPIN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPIN2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBE2E3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZC3H18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF214 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF263 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF324B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF786 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF816 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TOPORS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_RING IPR001841 0
Category members Znf_C3HC4_RING-type IPR018957 0


Protein complexes (CORUM database) featuring TOPORS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TOPORS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Database 0.83
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members GO Category GO:0016925 protein sumoylation Database 0.33
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0034504 protein localization to nucleus Database 0.15
Category members GO Category GO:0003823 antigen binding Database 0.13
Category members GO Category GO:0010842 retina layer formation Database 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0019789 SUMO ligase activity Database 0.05
Category members GO Category GO:0051457 maintenance of protein location in nucleus Database 0.05
Category members GO Category GO:0036064 ciliary basal body Database 0.05
Category members Disease phenotype Retinitis_pigmentosa Retinitis pigmentosa Database 0
Category members GO Category GO:0000930 gamma-tubulin complex Database 0
Category members GO Category GO:0005814 centriole Database 0
Category members GO Category GO:0005868 cytoplasmic dynein complex Database 0
Category members GO Category GO:0006513 protein monoubiquitination Database 0
Category members GO Category GO:0032391 photoreceptor connecting cilium Database 0
Category members GO Category GO:0035845 photoreceptor cell outer segment organization Database 0
Category members GO Category GO:0046548 retinal rod cell development Database 0
Category members GO Category GO:0046549 retinal cone cell development Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051443 positive regulation of ubiquitin-protein ligase activity Database 0
Category members GO Category GO:0070936 protein K48-linked ubiquitination Database 0


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