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Query: USP28

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
USP28 2 5.011 1.150 -0.550

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
USP28 Phosphorylation S495 2.593 2.418 _ESTSTESSS(ph)QDVESTFSSPEDSLPK_
USP28 Phosphorylation S1053 -0.658 -0.698 _EPPTIRPNS(ph)PYDLCSR_

Background Information for USP28:


Pubmed-USP28 »
Uniprot-USP28 »
Biogrid-USP28 »
ProteomicsDB-USP28 »

Tumorportal-USP28 »
COSMIC-USP28 »
GenomeRNAi-USP28 »
Genecards-USP28


Protein-protein Interactions for USP28
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PPP6C Cat. description Hein, Mann, Cell 2015
Category members IP bait TP53BP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait COMTD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SENP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPPL2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ST6GAL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in USP28
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members UCH/PAN2 IPR028889 0.62
Category members Peptidase_C19_UCH IPR001394 0.53
Category members UBA-like IPR009060 0.17


Protein complexes (CORUM database) featuring USP28
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring USP28
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0004843 ubiquitin-specific protease activity Database 3.28
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0000077 DNA damage checkpoint Database 2.04
Category members GO Category GO:0010212 response to ionizing radiation Database 1.66
Category members GO Category GO:0004221 ubiquitin thiolesterase activity Database 1.36
Category members GO Category GO:0016579 protein deubiquitination Database 1.32
Category members GO Category GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Database 0.83
Category members GO Category GO:0034644 cellular response to UV Database 0.49
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0008234 cysteine-type peptidase activity Database 0


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