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ESC/E(Z) complex
(GO:0035098)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
RBBP4 1 2.110 -1.240 0.533 -0.610 0.648
HDAC2 1 -2.390 4.970
HDAC2 1 -2.390 4.970 0.187 -0.007 0.825
JARID2 0 -1.180 1.730 -1.360 -1.367
EED 0 -1.210 1.980 0.099 0.896 0.548
SIRT1 0 0.910 -0.910
RBBP7 0 -0.080 -0.020 0.602 0.336 0.890 0.363 0.402
RBBP7 0 -0.080 -0.020 0.397 0.000 0.776
RBBP7 0 -0.080 -0.020
EZH2 0 1.100 -0.960 0.524 0.464 -0.045
AEBP2 0 0.100 0.240
MTF2 0 1.093 0.072
SUZ12 0 -0.710 0.770 0.451 1.156
SUZ12 0 -0.710 0.770 -0.670 0.955 0.457

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
AEBP2 Phosphorylation S24 -1.401 _(ac)AAAITDMADLEELS(ph)RLSPLPPGS(ph)PGSAAR_
AEBP2 Phosphorylation S141 -0.086 0.133 _SLS(ph)PGAASSSSGDGDGKEGLEEPK_
AEBP2 Phosphorylation S206 0.362 0.392 _RGS(ph)LEMSSDGEPLSR_
AEBP2 Phosphorylation S390 0.707 _S(ph)LPRPHDFFDAQTLDAIR_
EZH2 Ubiquitylation K61 0.548 _TEILNQEWK(gl)QR_
EZH2 Phosphorylation S363 0.010 -0.733 _GRLPNNSS(ph)RPSTPTINVLESK_
EZH2 Phosphorylation S366 -0.266 -0.699 _GRLPNNSSRPS(ph)TPTINVLESK_
EZH2 Phosphorylation T367 0.320 -0.372 _LPNNSSRPST(ph)PTINVLESK_
EZH2 Phosphorylation T369 -0.911 _GRLPNNSSRPSTPT(ph)INVLESK_
EZH2 Phosphorylation T487 -0.501 -0.532 _VKESSIIAPAPAEDVDT(ph)PPR_
EZH2 Ubiquitylation K569 -0.974 _AQCNTK(gl)QCPCYLAVR_
EZH2 Ubiquitylation K713 -0.461 _IGIFAK(gl)R_
EZH2 Ubiquitylation K735 0.038 _YSQADALK(gl)YVGIER_
HDAC2 Ubiquitylation K50 0.036 _K(gl)MEIYRPHK_
HDAC2 Ubiquitylation K67 -0.467 _ATAEEMTK(gl)YHSDEYIK_
HDAC2 Ubiquitylation K89 0.749 -0.241 _SIRPDNMSEYSK(gl)QMQR_
HDAC2 Ubiquitylation K284 0.749 _GHAK(gl)CVEVVK_
HDAC2 Phosphorylation S394 -0.865 -0.997 _M(ox)LPHAPGVQM(ox)QAIPEDAVHEDS(ph)GDEDGEDPDKR_
HDAC2 Phosphorylation S422 0.482 0.781 _IACDEEFS(ph)DSEDEGEGGR_
JARID2 Phosphorylation S455 -0.219 -0.009 _LEEAHQAEKPQS(ph)PPK_
RBBP4 Ubiquitylation K4 0.699 0.574 _(ac)ADK(gl)EAAFDDAVEER_
RBBP4 Ubiquitylation K160 -1.765 _HPSK(gl)PDPSGECNPDLR_
RBBP7 Phosphorylation S3 1.036 1.447 _(ac)AS(ph)KEMFEDTVEER_
RBBP7 Ubiquitylation K4 0.122 -0.804 _(ac)ASK(gl)EMFEDTVEER_
RBBP7 Ubiquitylation K21 0.081 -0.004 _VINEEYK(gl)IWK_
RBBP7 Phosphorylation S145 0.319 1.248 _TPS(ph)SDVLVFDYTK_
RBBP7 Ubiquitylation K159 -1.249 -3.808 _HPAK(gl)PDPSGECNPDLR_
RBBP7 Ubiquitylation K214 -0.021 _EGK(gl)IVDAK_
RBBP7 Ubiquitylation K236 0.469 _DSSVK(gl)LYQTR_
SIRT1 Phosphorylation S14 -0.369 -0.246 _(ac)ADEAALALQPGGS(ph)PSAAGADR_
SIRT1 Phosphorylation S16 -0.306 -1.665 _(ac)ADEAALALQPGGS(ph)PS(ph)AAGADREAASSPAGEPLR_
SIRT1 Phosphorylation S26 -1.047 -0.245 _EAAS(ph)SPAGEPLR_
SIRT1 Phosphorylation S27 0.351 -0.363 _EAASS(ph)PAGEPLR_
SIRT1 Phosphorylation S47 -0.574 -0.607 _S(ph)PGEPGGAAPER_
SIRT1 Ubiquitylation K238 -1.641 _RK(gl)DINTIEDAVK_
SIRT1 Ubiquitylation K499 -2.138 -0.204 _LGGEYAK(gl)LCCNPVK_
SIRT1 Ubiquitylation K578 -2.782 _GCMEEK(gl)PQEVQTSR_
SIRT1 Ubiquitylation K601 -3.051 _NVESIAEQMENPDLK(gl)NVGSSTGEK_
SUZ12 Ubiquitylation K341 -0.110 -0.960 _ATWETILDGK(gl)R_
SUZ12 Ubiquitylation K390 -0.696 _NSESLHQENK(gl)PGSVKPTQTIAVK_
SUZ12 Phosphorylation S546 0.533 0.248 _ASM(ox)SEFLES(ph)EDGEVEQQR_
SUZ12 Phosphorylation S583 -0.295 _LYFHSDTCLPLRPQEMEVDS(ph)EDEKDPEWLR_


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