bioLOGIC-db

bioLOGIC Data

Query: SUZ12

This is a cancer-associated gene according to the Sanger cancer gene census.

[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
SUZ12	0	2.830	-0.710	0.770		0.451	1.156
SUZ12	0	2.830	-0.710	0.770	-0.670			0.955	0.457

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
SUZ12	Phosphorylation	S546	0.533	0.248	_ASM(ox)SEFLES(ph)EDGEVEQQR_
SUZ12	Phosphorylation	S583		-0.295	_LYFHSDTCLPLRPQEMEVDS(ph)EDEKDPEWLR_
SUZ12	Ubiquitylation	K341	-0.110	-0.960	_ATWETILDGK(gl)R_
SUZ12	Ubiquitylation	K390	-0.696		_NSESLHQENK(gl)PGSVKPTQTIAVK_

ProteomicsDB-SUZ12 »

Protein-protein Interactions for SUZ12

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait EED	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait EZH2	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait AEBP2	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait BTRC	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait C9orf3	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait FBXW11	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait INTU	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait PHF19	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait RBBP7	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait SUZ12	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in SUZ12

	Domain name	Domain Description	TC-NER relevance -log10(p-value)

Protein complexes (CORUM database) featuring SUZ12

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	Corum	105	Polycomb repressive complex 2 (PRC 2)	Database	0.57
Category members	Corum	995	Polycomb repressive complex 3 (PRC3)	Database	0.57
Category members	Corum	996	Polycomb repressive complex 2 (PRC2)	Database	0.57
Category members	Corum	974	EED-EZH2 complex	Database	0.31

Categories featuring SUZ12

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005634	nucleus	Database	INF
Category members	GO Category	GO:0003682	chromatin binding	Database	6.07
Category members	Human mutations	Sanger_cancer_genes	Sanger cancer genes	Database	4.88
Category members	GO Category	GO:0001739	sex chromatin	Database	1.47
Category members	GO Category	GO:0006351	transcription, DNA-templated	Database	1.07
Category members	GO Category	GO:0035064	methylated histone residue binding	Database	0.53
Category members	GO Category	GO:0035098	ESC/E(Z) complex	Database	0.47
Category members	GO Category	GO:0016574	histone ubiquitination	Database	0.2
Category members	GO Category	GO:0043565	sequence-specific DNA binding	Database	0.18
Category members	GO Category	GO:0016571	histone methylation	Database	0.08
Category members	Disease phenotype	17q11_microdeletion_syndrome	17q11 microdeletion syndrome	Database	0.04
Category members	GO Category	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Database	0.02
Category members	GO Category	GO:0008284	positive regulation of cell proliferation	Database	0
Category members	GO Category	GO:0042054	histone methyltransferase activity	Database	0
Category members	GO Category	GO:0045596	negative regulation of cell differentiation	Database	0
Category members	GO Category	GO:0046872	metal ion binding	Database	0