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Query: HDAC2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HDAC2 1 7.747 -2.390 4.970
HDAC2 1 7.747 -2.390 4.970 0.187 -0.007 0.825

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HDAC2 Phosphorylation S422 0.482 0.781 _IACDEEFS(ph)DSEDEGEGGR_
HDAC2 Ubiquitylation K89 0.749 -0.241 _SIRPDNMSEYSK(gl)QMQR_
HDAC2 Ubiquitylation K67 -0.467 _ATAEEMTK(gl)YHSDEYIK_
HDAC2 Phosphorylation S394 -0.865 -0.997 _M(ox)LPHAPGVQM(ox)QAIPEDAVHEDS(ph)GDEDGEDPDKR_
HDAC2 Ubiquitylation K50 0.036 _K(gl)MEIYRPHK_
HDAC2 Ubiquitylation K284 0.749 _GHAK(gl)CVEVVK_

Background Information for HDAC2:


Pubmed-HDAC2 »
Uniprot-HDAC2 »
Biogrid-HDAC2 »
ProteomicsDB-HDAC2 »

Tumorportal-HDAC2 »
COSMIC-HDAC2 »
GenomeRNAi-HDAC2 »
Genecards-HDAC2


Protein-protein Interactions for HDAC2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK2AP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ELMSAN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM60A Cat. description Hein, Mann, Cell 2015
Category members IP bait GATAD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HMG20A Cat. description Hein, Mann, Cell 2015
Category members IP bait L3MBTL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MBD2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MPP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PHF12 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait SAP30 Cat. description Hein, Mann, Cell 2015
Category members IP bait WIZ Cat. description Hein, Mann, Cell 2015
Category members IP bait ZMYND8 Cat. description Hein, Mann, Cell 2015
Category members IP bait C22orf31 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CYBRD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM60A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GATAD2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HDAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H2BA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HMG20A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HMG20B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ING2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait L3MBTL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MBD3L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MIER2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCGF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PHF20L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBBP7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF219 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HDAC2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members His_deacetylse_1 IPR003084 0.12
Category members His_deacetylse IPR000286 0
Category members His_deacetylse_dom IPR023801 0


Protein complexes (CORUM database) featuring HDAC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 282 SNF2h-cohesin-NuRD complex Database 6.11
Category members Corum 778 LARC complex (LCR-associated remodeling complex) Database 5.04
Category members Corum 1257 ALL-1 supercomplex Database 4.3
Category members Corum 739 SIN3-ING1b complex II Database 4.24
Category members Corum 659 MeCP1 complex Database 4.17
Category members Corum 685 MeCP1 complex Database 4.17
Category members Corum 714 BRM-SIN3A complex Database 4.02
Category members Corum 642 CtBP complex Database 3.6
Category members Corum 62 MeCP1 complex Database 3.53
Category members Corum 713 BRG1-SIN3A complex Database 3.51
Category members Corum 61 Mi2/NuRD complex Database 2.87
Category members Corum 806 BRM-SIN3A-HDAC complex Database 2.48
Category members Corum 614 NRD complex (Nucleosome remodeling and deacetylation complex) Database 2.26
Category members Corum 650 HDAC2-asscociated core complex Database 2.26
Category members Corum 888 MTA2 complex Database 2.24
Category members Corum 632 Anti-HDAC2 complex Database 2.11
Category members Corum 2721 HCF-1 complex Database 2.08
Category members Corum 803 BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I Database 2.01
Category members Corum 3048 mSin3A complex Database 1.84
Category members Corum 691 SIN3-SAP25 complex Database 1.77
Category members Corum 743 SIN3-SAP25 complex Database 1.77
Category members Corum 591 SAP complex (Sin3-associated protein complex) Database 1.75
Category members Corum 886 MTA1 complex Database 1.68
Category members Corum 283 Sin3 complex Database 1.47
Category members Corum 54 SIN3 complex Database 1.47
Category members Corum 732 SIN3 complex Database 1.47
Category members Corum 738 SIN3-ING1b complex I Database 1.47
Category members Corum 596 SIN3-HDAC-SAP30-ARID4 complex Database 1.42
Category members Corum 695 SIN3-HDAC-SAP30-ARID4 complex Database 1.42
Category members Corum 698 SIN3-HDAC-SAP30-ARID4 complex Database 1.42
Category members Corum 889 MTA1-HDAC core complex Database 1.41
Category members Corum 643 CtBP core complex Database 1.41
Category members Corum 592 SAP complex (Sin3-associated protein complex) Database 1.33
Category members Corum 749 MeCP2-SIN3A-HDAC complex Database 1.25
Category members Corum 634 XFIM complex Database 1.15
Category members Corum 3167 NCOR-SIN3-HDAC-HESX1 complex Database 0.94
Category members Corum 2814 BRCA1-HDAC1-HDAC2 complex Database 0.85
Category members Corum 1134 ATR-HDAC2-CHD4 complex Database 0.77
Category members Corum 2851 ING2 complex Database 0.74
Category members Corum 3053 mSin3A-HDAC1-HDAC2 complex Database 0.72
Category members Corum 696 BRMS1-SIN3-HDAC complex Database 0.66
Category members Corum 633 anti-BHC110 complex Database 0.53
Category members Corum 636 BHC complex Database 0.53
Category members Corum 745 NCOR-SIN3-RPD3 complex Database 0.47
Category members Corum 1492 BHC110 complex Database 0.39
Category members Corum 1133 ATR-HDAC2 complex Database 0.35
Category members Corum 620 CoREST-HDAC complex Database 0.34
Category members Corum 871 BRAF53-BRCA2 complex Database 0.34
Category members Corum 1458 SNF2h-HDAC12 complex Database 0.33
Category members Corum 1233 CoREST-HDAC2 complex Database 0.32
Category members Corum 1505 NCOR2 complex Database 0.15
Category members Corum 2657 ESR1-CDK7-CCNH-MNAT1-MTA1-HDAC2 complex Database 0.15
Category members Corum 3054 MAD1-mSin3A-HDAC2 complex Database 0.08


Categories featuring HDAC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0000792 heterochromatin Database 5.45
Category members GO Category GO:0006338 chromatin remodeling Database 4.95
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members GO Category GO:0000785 chromatin Database 2.59
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0031072 heat shock protein binding Database 1.59
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0016581 NuRD complex Database 1.15
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0005657 replication fork Database 0.95
Category members GO Category GO:0045786 negative regulation of cell cycle Database 0.93
Category members GO Category GO:0061198 fungiform papilla formation Database 0.68
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0051896 regulation of protein kinase B signaling Database 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members GO Category GO:0035098 ESC/E(Z) complex Database 0.47
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0001103 RNA polymerase II repressing transcription factor binding Database 0.36
Category members GO Category GO:0016580 Sin3 complex Database 0.35
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity Database 0.18
Category members GO Category GO:0034605 cellular response to heat Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0060297 regulation of sarcomere organization Database 0.17
Category members GO Category GO:0060789 hair follicle placode formation Database 0.17
Category members Pathway Pathway_824 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION 0 0.14
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0001047 core promoter binding Database 0.11
Category members Pathway Pathway_984 PID_HEDGEHOG_GLI_PATHWAY 0 0.1
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members GO Category GO:0048714 positive regulation of oligodendrocyte differentiation Database 0.07
Category members GO Category GO:0060044 negative regulation of cardiac muscle cell proliferation Database 0.06
Category members GO Category GO:0010977 negative regulation of neuron projection development Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0045347 negative regulation of MHC class II biosynthetic process Database 0.01
Category members Pathway Pathway_1097 BIOCARTA_ETS_PATHWAY 0 0
Category members Pathway Pathway_1144 BIOCARTA_MEF2D_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_365 BIOCARTA_CARM_ER_PATHWAY 0 0
Category members Pathway Pathway_892 KEGG_NOTCH_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0004407 histone deacetylase activity Database 0
Category members GO Category GO:0006344 maintenance of chromatin silencing Database 0
Category members GO Category GO:0006476 protein deacetylation Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009913 epidermal cell differentiation Database 0
Category members GO Category GO:0010870 positive regulation of receptor biosynthetic process Database 0
Category members GO Category GO:0016358 dendrite development Database 0
Category members GO Category GO:0016575 histone deacetylation Database 0
Category members GO Category GO:0021766 hippocampus development Database 0
Category members GO Category GO:0030182 neuron differentiation Database 0
Category members GO Category GO:0031490 chromatin DNA binding Database 0
Category members GO Category GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) Database 0
Category members GO Category GO:0032967 positive regulation of collagen biosynthetic process Database 0
Category members GO Category GO:0033558 protein deacetylase activity Database 0
Category members GO Category GO:0042220 response to cocaine Database 0
Category members GO Category GO:0042475 odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0042733 embryonic digit morphogenesis Database 0
Category members GO Category GO:0045862 positive regulation of proteolysis Database 0
Category members GO Category GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) Database 0
Category members GO Category GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0055013 cardiac muscle cell development Database 0
Category members GO Category GO:0061029 eyelid development in camera-type eye Database 0


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