bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: EZH2

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EZH2 0 0.978 1.100 -0.960 0.524 0.464 -0.045

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EZH2 Phosphorylation T367 0.320 -0.372 _LPNNSSRPST(ph)PTINVLESK_
EZH2 Ubiquitylation K713 -0.461 _IGIFAK(gl)R_
EZH2 Phosphorylation T487 -0.501 -0.532 _VKESSIIAPAPAEDVDT(ph)PPR_
EZH2 Phosphorylation S366 -0.266 -0.699 _GRLPNNSSRPS(ph)TPTINVLESK_
EZH2 Phosphorylation S363 0.010 -0.733 _GRLPNNSS(ph)RPSTPTINVLESK_
EZH2 Phosphorylation T369 -0.911 _GRLPNNSSRPSTPT(ph)INVLESK_
EZH2 Ubiquitylation K569 -0.974 _AQCNTK(gl)QCPCYLAVR_
EZH2 Ubiquitylation K61 0.548 _TEILNQEWK(gl)QR_
EZH2 Ubiquitylation K735 0.038 _YSQADALK(gl)YVGIER_

Background Information for EZH2:


Pubmed-EZH2 »
Uniprot-EZH2 »
Biogrid-EZH2 »
ProteomicsDB-EZH2 »

Tumorportal-EZH2 »
COSMIC-EZH2 »
GenomeRNAi-EZH2 »
Genecards-EZH2


Protein-protein Interactions for EZH2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait EED Cat. description Hein, Mann, Cell 2015
Category members IP bait EZH2 Cat. description Hein, Mann, Cell 2015
Category members IP bait GEMIN7 Cat. description Hein, Mann, Cell 2015
Category members IP bait AEBP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BTRC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PHF19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBBP7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUZ12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EZH2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SANT/Myb IPR001005 2.18
Category members HSP70_C IPR029048 0.66
Category members SET_dom IPR001214 0.29
Category members Homeodomain-like IPR009057 0
Category members EZH2_WD-Binding IPR021654 0


Protein complexes (CORUM database) featuring EZH2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 105 Polycomb repressive complex 2 (PRC 2) Database 0.57
Category members Corum 995 Polycomb repressive complex 3 (PRC3) Database 0.57
Category members Corum 996 Polycomb repressive complex 2 (PRC2) Database 0.57
Category members Corum 974 EED-EZH2 complex Database 0.31
Category members Corum 5502 EED-EZH-YY1 polycomb complex Database 0.04
Category members Corum 1177 Polycomb repressive complex 4 (PRC4) Database 0
Category members Corum 5521 EED-EZH polycomb complex Database 0


Categories featuring EZH2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0006325 chromatin organization Database 5.02
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members GO Category GO:0018024 histone-lysine N-methyltransferase activity Database 0.73
Category members GO Category GO:0035098 ESC/E(Z) complex Database 0.47
Category members GO Category GO:0045120 pronucleus Database 0.27
Category members GO Category GO:0032320 positive regulation of Ras GTPase activity Database 0.26
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0050767 regulation of neurogenesis Database 0.14
Category members GO Category GO:0010718 positive regulation of epithelial to mesenchymal transition Database 0.13
Category members GO Category GO:0000975 regulatory region DNA binding Database 0.11
Category members GO Category GO:0001047 core promoter binding Database 0.11
Category members GO Category GO:0045814 negative regulation of gene expression, epigenetic Database 0.11
Category members GO Category GO:0016571 histone methylation Database 0.08
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0001932 regulation of protein phosphorylation Database 0.04
Category members GO Category GO:0070734 histone H3-K27 methylation Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0048387 negative regulation of retinoic acid receptor signaling pathway Database 0.01
Category members Disease phenotype Weaver_syndrome Weaver syndrome Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0021695 cerebellar cortex development Database 0
Category members GO Category GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter Database 0
Category members GO Category GO:0042054 histone methyltransferase activity Database 0
Category members GO Category GO:0043406 positive regulation of MAP kinase activity Database 0
Category members GO Category GO:0051154 negative regulation of striated muscle cell differentiation Database 0
Category members GO Category GO:0070314 G1 to G0 transition Database 0


.

© Copyright Svejstrup Laboratory 2015