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methylation-dependent chromatin silencing
(GO:0006346)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
W

Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
MBD3 0 0.730 -1.260 0.210 0.189 0.976 0.079 0.453
DNMT3B 0 0.990 -0.100 0.783 0.015
SIRT1 0 0.910 -0.910
HELLS 0 -1.320 1.650 -1.393 -0.483 -0.069 -0.340 -0.345
SMARCA4 0 -0.810 1.520 0.629 -0.158 0.141 0.337 0.333

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
DNMT3B Ubiquitylation K597 0.236 _ELGIK(gl)VGK_
DNMT3B Ubiquitylation K623 0.433 _HEGNIK(gl)YVNDVR_
HELLS Ubiquitylation K74 0.655 _LQHLLEK(gl)SNIYSK_
HELLS Phosphorylation S115 0.257 _NS(ph)IDASEEKPVMR_
HELLS Ubiquitylation K474 -0.723 _EVVVYAPLSK(gl)K_
HELLS Ubiquitylation K475 -0.723 _EVVVYAPLSK(gl)K_
HELLS Ubiquitylation K753 0.741 _NHFK(gl)GGQSGLNLSK_
HELLS Ubiquitylation K776 0.359 _ELMELLK(gl)SR_
MBD3 Ubiquitylation K42 -0.711 _DVFYYSPSGKK(gl)_
MBD3 Phosphorylation S56 0.663 0.474 _YLGGS(ph)MDLSTFDFR_
MBD3 Phosphorylation S85 0.574 0.485 _VRYDS(ph)SNQVK_
MBD3 Ubiquitylation K92 -0.542 _GK(gl)PDLNTALPVR_
MBD3 Ubiquitylation K124 0.195 _ITNHPSNKVK(gl)_
MBD3 Ubiquitylation K129 -0.498 _SDPQK(gl)AVDQPR_
SIRT1 Phosphorylation S14 -0.369 -0.246 _(ac)ADEAALALQPGGS(ph)PSAAGADR_
SIRT1 Phosphorylation S16 -0.306 -1.665 _(ac)ADEAALALQPGGS(ph)PS(ph)AAGADREAASSPAGEPLR_
SIRT1 Phosphorylation S26 -1.047 -0.245 _EAAS(ph)SPAGEPLR_
SIRT1 Phosphorylation S27 0.351 -0.363 _EAASS(ph)PAGEPLR_
SIRT1 Phosphorylation S47 -0.574 -0.607 _S(ph)PGEPGGAAPER_
SIRT1 Ubiquitylation K238 -1.641 _RK(gl)DINTIEDAVK_
SIRT1 Ubiquitylation K499 -2.138 -0.204 _LGGEYAK(gl)LCCNPVK_
SIRT1 Ubiquitylation K578 -2.782 _GCMEEK(gl)PQEVQTSR_
SIRT1 Ubiquitylation K601 -3.051 _NVESIAEQMENPDLK(gl)NVGSSTGEK_
SMARCA4 Ubiquitylation K357 -0.934 _ITPIQK(gl)PR_
SMARCA4 Ubiquitylation K405 0.109 1.148 _ATIELK(gl)ALR_
SMARCA4 Ubiquitylation K437 -0.317 _DTALETALNAK(gl)AYKR_
SMARCA4 Ubiquitylation K455 0.225 _ITEK(gl)LEK_
SMARCA4 Ubiquitylation K496 0.923 _SVTGK(gl)IQK_
SMARCA4 Phosphorylation S677 -0.880 -0.324 _KAENAEGQTPAIGPDGEPLDETSQMS(ph)DLPVK_
SMARCA4 Ubiquitylation K1283 0.125 _ILAAAK(gl)YK_
SMARCA4 Phosphorylation S1413 -0.265 0.515 _EVDYSDS(ph)LTEK_
SMARCA4 Phosphorylation S1486 -0.713 -0.935 _LS(ph)PNPPNLTK_


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