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Query: HELLS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HELLS 0 0.377 -1.320 1.650 -1.393 -0.483 -0.069 -0.340 -0.345

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HELLS Ubiquitylation K776 0.359 _ELMELLK(gl)SR_
HELLS Phosphorylation S115 0.257 _NS(ph)IDASEEKPVMR_
HELLS Ubiquitylation K474 -0.723 _EVVVYAPLSK(gl)K_
HELLS Ubiquitylation K475 -0.723 _EVVVYAPLSK(gl)K_
HELLS Ubiquitylation K74 0.655 _LQHLLEK(gl)SNIYSK_
HELLS Ubiquitylation K753 0.741 _NHFK(gl)GGQSGLNLSK_

Background Information for HELLS:


Pubmed-HELLS »
Uniprot-HELLS »
Biogrid-HELLS »
ProteomicsDB-HELLS »

Tumorportal-HELLS »
COSMIC-HELLS »
GenomeRNAi-HELLS »
Genecards-HELLS


Protein-protein Interactions for HELLS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CBX4 Cat. description Hein, Mann, Cell 2015
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait FBL Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CA Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC1A Cat. description Hein, Mann, Cell 2015
Category members IP bait VAPA Cat. description Hein, Mann, Cell 2015
Category members IP bait C3AR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD79B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait F9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HELLS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LAMP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LYPD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDGFRB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PVR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM150A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM171 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP47 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR76 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HELLS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SNF2_N IPR000330 3.38
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members Helicase/UvrB_dom IPR006935 0.78
Category members HDA_complex_subunit-2/3 IPR021006 0.04


Protein complexes (CORUM database) featuring HELLS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HELLS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0031508 centromeric heterochromatin assembly Database 0.3
Category members GO Category GO:0006346 methylation-dependent chromatin silencing Database 0.3
Category members GO Category GO:0005721 centromeric heterochromatin Database 0.3
Category members GO Category GO:0000775 chromosome, centromeric region Database 0.29
Category members GO Category GO:0006306 DNA methylation Database 0.22
Category members Pathway Pathway_209 PID_DELTA_NP63_PATHWAY 0 0
Category members GO Category GO:0001655 urogenital system development Database 0
Category members GO Category GO:0006342 chromatin silencing Database 0
Category members GO Category GO:0010216 maintenance of DNA methylation Database 0
Category members GO Category GO:0046651 lymphocyte proliferation Database 0


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