bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: SMARCA4

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMARCA4 0 4.441 -0.810 1.520 0.629 -0.158 0.141 0.337 0.333

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMARCA4 Ubiquitylation K405 0.109 1.148 _ATIELK(gl)ALR_
SMARCA4 Ubiquitylation K496 0.923 _SVTGK(gl)IQK_
SMARCA4 Phosphorylation S1413 -0.265 0.515 _EVDYSDS(ph)LTEK_
SMARCA4 Phosphorylation S677 -0.880 -0.324 _KAENAEGQTPAIGPDGEPLDETSQMS(ph)DLPVK_
SMARCA4 Phosphorylation S1486 -0.713 -0.935 _LS(ph)PNPPNLTK_
SMARCA4 Ubiquitylation K357 -0.934 _ITPIQK(gl)PR_
SMARCA4 Ubiquitylation K437 -0.317 _DTALETALNAK(gl)AYKR_
SMARCA4 Ubiquitylation K455 0.225 _ITEK(gl)LEK_
SMARCA4 Ubiquitylation K1283 0.125 _ILAAAK(gl)YK_

Background Information for SMARCA4:


Pubmed-SMARCA4 »
Uniprot-SMARCA4 »
Biogrid-SMARCA4 »
ProteomicsDB-SMARCA4 »

Tumorportal-SMARCA4 »
COSMIC-SMARCA4 »
GenomeRNAi-SMARCA4 »
Genecards-SMARCA4


Protein-protein Interactions for SMARCA4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATL2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BCL7C Cat. description Hein, Mann, Cell 2015
Category members IP bait CAT Cat. description Hein, Mann, Cell 2015
Category members IP bait KPNA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEIL3 Cat. description Hein, Mann, Cell 2015
Category members IP bait PAPD5 Cat. description Hein, Mann, Cell 2015
Category members IP bait PARD6A Cat. description Hein, Mann, Cell 2015
Category members IP bait PCDH1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMB4 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB5C Cat. description Hein, Mann, Cell 2015
Category members IP bait REEP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ROCK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMARCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TOR1AIP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait VAPA Cat. description Hein, Mann, Cell 2015
Category members IP bait BCL7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL7C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SS18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMARCA4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SNF2_N IPR000330 3.38
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members Bromodomain IPR001487 1.43
Category members HAS_subgr IPR013999 0.68
Category members Helicase/SANT-assoc_DNA-bd IPR014012 0.68
Category members Gln-Leu-Gln_QLQ IPR014978 0.28
Category members BRK_domain IPR006576 0


Protein complexes (CORUM database) featuring SMARCA4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 778 LARC complex (LCR-associated remodeling complex) Database 5.04
Category members Corum 739 SIN3-ING1b complex II Database 4.24
Category members Corum 1230 WINAC complex Database 3.79
Category members Corum 713 BRG1-SIN3A complex Database 3.51
Category members Corum 1252 EBAFa complex Database 2.5
Category members Corum 1237 BAF complex Database 2.03
Category members Corum 555 BAF complex Database 2.03
Category members Corum 564 BAF complex Database 2.03
Category members Corum 803 BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I Database 2.01
Category members Corum 1239 EBAFb complex Database 1.57
Category members Corum 1251 BAF complex Database 1.57
Category members Corum 238 SWI-SNF chromatin remodeling-related-BRCA1 complex Database 1.57
Category members Corum 554 PBAF complex (Polybromo- and BAF containing complex) Database 1.57
Category members Corum 565 PBAF complex (Polybromo- and BAF containing complex) Database 1.57
Category members Corum 566 BAF complex Database 1.57
Category members Corum 710 Brg1-associated complex I Database 1.57
Category members Corum 149 PBAF complex (Polybromo- and BAF containing complex) Database 1.36
Category members Corum 189 BAF complex Database 1.36
Category members Corum 1238 PBAF complex (Polybromo- and BAF containing complex) Database 1.16
Category members Corum 556 PBAF complex (Polybromo- and BAF containing complex) Database 1.16
Category members Corum 807 BRG1-associated complex Database 1.16
Category members Corum 3066 RNA polymerase II complex, chromatin structure modifying Database 0.92
Category members Corum 86 NUMAC complex (nucleosomal methylation activator complex) Database 0.83
Category members Corum 1413 NCOR1 complex Database 0.65
Category members Corum 3064 RNA polymerase II complex, chromatin structure modifying Database 0.64
Category members Corum 3063 Brg1-associated complex II Database 0.62
Category members Corum 570 p300-CBP-p270-SWI/SNF complex Database 0.62
Category members Corum 3269 RB1-HDAC1-BRG1 complex Database 0.49
Category members Corum 3060 RNA polymerase II complex (RPB1, RAP74, CDK8, CYCC, SRB7, BAF190, BAF47), chromatin structure modifying Database 0.35
Category members Corum 5293 ETS2-SMARCA4-INI1 complex Database 0.08
Category members Corum 2829 RSmad complex Database 0.06


Categories featuring SMARCA4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0000792 heterochromatin Database 5.45
Category members GO Category GO:0006338 chromatin remodeling Database 4.95
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0006337 nucleosome disassembly Database 3
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0008094 DNA-dependent ATPase activity Database 2.31
Category members GO Category GO:0016514 SWI/SNF complex Database 2.12
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Database 1.64
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_1260 PID_ERB_GENOMIC_PATHWAY 0 1.04
Category members GO Category GO:0010424 DNA methylation on cytosine within a CG sequence Database 0.98
Category members GO Category GO:0070577 histone acetyl-lysine binding Database 0.88
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0001832 blastocyst growth Database 0.83
Category members GO Category GO:0030957 Tat protein binding Database 0.73
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members Disease phenotype COFFIN-SIRIS_SYNDROME COFFIN-SIRIS SYNDROME Database 0.53
Category members GO Category GO:0001889 liver development Database 0.51
Category members GO Category GO:0019827 stem cell maintenance Database 0.48
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members Disease phenotype Coffin_Siris Coffin Siris Database 0.43
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0060766 negative regulation of androgen receptor signaling pathway Database 0.35
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members GO Category GO:0006346 methylation-dependent chromatin silencing Database 0.3
Category members Disease phenotype Familial_rhabdoid_tumor Familial rhabdoid tumor Database 0.29
Category members GO Category GO:0007403 glial cell fate determination Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0035887 aortic smooth muscle cell differentiation Database 0.28
Category members GO Category GO:0043923 positive regulation by host of viral transcription Database 0.27
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members GO Category GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding Database 0.21
Category members GO Category GO:0007070 negative regulation of transcription from RNA polymerase II promoter during mitosis Database 0.2
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members GO Category GO:0022008 neurogenesis Database 0.16
Category members GO Category GO:0005719 nuclear euchromatin Database 0.15
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0050681 androgen receptor binding Database 0.12
Category members GO Category GO:0005726 perichromatin fibrils Database 0.09
Category members GO Category GO:0001835 blastocyst hatching Database 0.08
Category members GO Category GO:0016817 hydrolase activity, acting on acid anhydrides Database 0.06
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0030902 hindbrain development Database 0.02
Category members GO Category GO:0000902 cell morphogenesis Database 0
Category members GO Category GO:0001105 RNA polymerase II transcription coactivator activity Database 0
Category members GO Category GO:0001570 vasculogenesis Database 0
Category members GO Category GO:0003407 neural retina development Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0030216 keratinocyte differentiation Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0035116 embryonic hindlimb morphogenesis Database 0
Category members GO Category GO:0043388 positive regulation of DNA binding Database 0
Category members GO Category GO:0043966 histone H3 acetylation Database 0
Category members GO Category GO:0048562 embryonic organ morphogenesis Database 0
Category members GO Category GO:0048730 epidermis morphogenesis Database 0
Category members GO Category GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0060318 definitive erythrocyte differentiation Database 0
Category members GO Category GO:0060347 heart trabecula formation Database 0


.

© Copyright Svejstrup Laboratory 2015