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Query: DNMT3B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DNMT3B 0 1.231 0.990 -0.100 0.783 0.015

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DNMT3B Ubiquitylation K597 0.236 _ELGIK(gl)VGK_
DNMT3B Ubiquitylation K623 0.433 _HEGNIK(gl)YVNDVR_

Background Information for DNMT3B:


Pubmed-DNMT3B »
Uniprot-DNMT3B »
Biogrid-DNMT3B »
ProteomicsDB-DNMT3B »

Tumorportal-DNMT3B »
COSMIC-DNMT3B »
GenomeRNAi-DNMT3B »
Genecards-DNMT3B


Protein-protein Interactions for DNMT3B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MAGOH;MAGOHB Cat. description Hein, Mann, Cell 2015
Category members IP bait SGOL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait UGGT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DNMT3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHGB4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DNMT3B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_FYVE_PHD IPR011011 1.23
Category members PWWP_dom IPR000313 0.63
Category members C5_MeTfrase IPR001525 0.23
Category members SAM-dependent_MTases-like IPR029063 0.04


Protein complexes (CORUM database) featuring DNMT3B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 49 DNMT3B complex Database 1.05
Category members Corum 5695 TIP5-DNMT-HDAC1 complex Database 0.98
Category members Corum 2650 DNMT3B-DNMT3L complex Database 0


Categories featuring DNMT3B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000792 heterochromatin Database 5.45
Category members GO Category GO:0010212 response to ionizing radiation Database 1.66
Category members GO Category GO:0006349 regulation of gene expression by genetic imprinting Database 1.64
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0005720 nuclear heterochromatin Database 1.41
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0051571 positive regulation of histone H3-K4 methylation Database 0.99
Category members GO Category GO:0010424 DNA methylation on cytosine within a CG sequence Database 0.98
Category members GO Category GO:0051573 negative regulation of histone H3-K9 methylation Database 0.84
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0046498 S-adenosylhomocysteine metabolic process Database 0.62
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0009008 DNA-methyltransferase activity Database 0.32
Category members GO Category GO:0006346 methylation-dependent chromatin silencing Database 0.3
Category members GO Category GO:0003886 DNA (cytosine-5-)-methyltransferase activity Database 0.23
Category members Disease phenotype ICF_syndrome ICF syndrome Database 0.22
Category members Disease phenotype IMMUNODEFICIENCY-CENTROMERIC_INSTABILITY-FACIAL_ANOMALIES_SYNDROME IMMUNODEFICIENCY-CENTROMERIC INSTABILITY-FACIAL ANOMALIES SYNDROME Database 0.22
Category members GO Category GO:0046499 S-adenosylmethioninamine metabolic process Database 0.22
Category members GO Category GO:0051718 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates Database 0.22
Category members GO Category GO:0006306 DNA methylation Database 0.22
Category members GO Category GO:0045322 unmethylated CpG binding Database 0.13
Category members Pathway Pathway_400 KEGG_CYSTEINE_AND_METHIONINE_METABOLISM 0 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0008168 methyltransferase activity Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0031503 protein complex localization Database 0
Category members GO Category GO:0045666 positive regulation of neuron differentiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0071230 cellular response to amino acid stimulus Database 0


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