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Query: MBD3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MBD3 0 3.250 0.730 -1.260 0.210 0.189 0.976 0.079 0.453

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MBD3 Phosphorylation S85 0.574 0.485 _VRYDS(ph)SNQVK_
MBD3 Phosphorylation S56 0.663 0.474 _YLGGS(ph)MDLSTFDFR_
MBD3 Ubiquitylation K42 -0.711 _DVFYYSPSGKK(gl)_
MBD3 Ubiquitylation K92 -0.542 _GK(gl)PDLNTALPVR_
MBD3 Ubiquitylation K124 0.195 _ITNHPSNKVK(gl)_
MBD3 Ubiquitylation K129 -0.498 _SDPQK(gl)AVDQPR_

Background Information for MBD3:


Pubmed-MBD3 »
Uniprot-MBD3 »
Biogrid-MBD3 »
ProteomicsDB-MBD3 »

Tumorportal-MBD3 »
COSMIC-MBD3 »
GenomeRNAi-MBD3 »
Genecards-MBD3


Protein-protein Interactions for MBD3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK2AP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait HDAC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KPNA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZMYND8 Cat. description Hein, Mann, Cell 2015
Category members IP bait C9orf25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GATAD2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GATAD2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HDAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait L3MBTL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PHF20L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBBP7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCF19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TXNIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBED1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF219 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF800 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MBD3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members Methyl_CpG_DNA-bd IPR001739 0
Category members DNA-bd_dom IPR016177 0


Protein complexes (CORUM database) featuring MBD3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 282 SNF2h-cohesin-NuRD complex Database 6.11
Category members Corum 778 LARC complex (LCR-associated remodeling complex) Database 5.04
Category members Corum 1257 ALL-1 supercomplex Database 4.3
Category members Corum 659 MeCP1 complex Database 4.17
Category members Corum 685 MeCP1 complex Database 4.17
Category members Corum 62 MeCP1 complex Database 3.53
Category members Corum 646 HDAC1-associated protein complex Database 3.34
Category members Corum 649 HDAC1-associated core complex cII Database 3.34
Category members Corum 61 Mi2/NuRD complex Database 2.87
Category members Corum 650 HDAC2-asscociated core complex Database 2.26
Category members Corum 888 MTA2 complex Database 2.24
Category members Corum 1495 PID complex Database 1.68
Category members Corum 886 MTA1 complex Database 1.68
Category members Corum 41 Mi-2/NuRD-MTA2 complex Database 0.67
Category members Corum 585 Mi2/NuRD-BCL6-MTA3 complex Database 0.67


Categories featuring MBD3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0000792 heterochromatin Database 5.45
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0016573 histone acetylation Database 1.24
Category members GO Category GO:0016581 NuRD complex Database 1.15
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_54 BIOCARTA_MTA3_PATHWAY 0 0.36
Category members GO Category GO:0006346 methylation-dependent chromatin silencing Database 0.3
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0009888 tissue development Database 0


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