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Query: DAG1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DAG1 0 1.743 0.210 -0.400

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DAG1 Ubiquitylation K793 0.843 _LTLEDQATFIK(gl)K_
DAG1 Ubiquitylation K794 0.899 _LTLEDQATFIKK(gl)_
DAG1 Ubiquitylation K881 -0.342 _GSRPK(gl)NMTPYR_

Background Information for DAG1:


Pubmed-DAG1 »
Uniprot-DAG1 »
Biogrid-DAG1 »
ProteomicsDB-DAG1 »

Tumorportal-DAG1 »
COSMIC-DAG1 »
GenomeRNAi-DAG1 »
Genecards-DAG1


Protein-protein Interactions for DAG1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C6orf72 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDH5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CEACAM21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FKBP9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-DPA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR3C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL13RA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS9C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHAC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHB11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHGA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHGB4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCTN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFSF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DAG1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cadherin-like IPR015919 0.21
Category members Cadg IPR006644 0


Protein complexes (CORUM database) featuring DAG1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 422 Beta-dystroglycan-caveolin-3 complex Database 0.04
Category members Corum 753 UTM-SGCE-DAG1-CAV1-NOS3 complex Database 0.02


Categories featuring DAG1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members GO Category GO:0006607 NLS-bearing protein import into nucleus Database 1.48
Category members GO Category GO:0043034 costamere Database 1.42
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005913 cell-cell adherens junction Database 1.05
Category members GO Category GO:0017166 vinculin binding Database 1.01
Category members GO Category GO:0034453 microtubule anchoring Database 0.97
Category members GO Category GO:0043409 negative regulation of MAPK cascade Database 0.87
Category members GO Category GO:0030336 negative regulation of cell migration Database 0.85
Category members GO Category GO:0001618 virus receptor activity Database 0.83
Category members GO Category GO:0015631 tubulin binding Database 0.83
Category members GO Category GO:0007016 cytoskeletal anchoring at plasma membrane Database 0.74
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0014044 Schwann cell development Database 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0042383 sarcolemma Database 0.36
Category members GO Category GO:0022011 myelination in peripheral nervous system Database 0.33
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members Pathway Pathway_535 SIG_BCR_SIGNALING_PATHWAY 0 0.24
Category members Pathway Pathway_514 ST_GAQ_PATHWAY 0 0.17
Category members GO Category GO:0006509 membrane protein ectodomain proteolysis Database 0.14
Category members Pathway Pathway_1041 BIOCARTA_AGR_PATHWAY 0 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Pathway Pathway_735 ST_MYOCYTE_AD_PATHWAY 0 0.09
Category members Pathway Pathway_513 ST_ADRENERGIC 0 0.08
Category members GO Category GO:0045211 postsynaptic membrane Database 0.06
Category members GO Category GO:0030175 filopodium Database 0.05
Category members Pathway Pathway_518 ST_G_ALPHA_I_PATHWAY 0 0.05
Category members GO Category GO:0016010 dystrophin-associated glycoprotein complex Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members Pathway Pathway_306 ST_WNT_CA2_CYCLIC_GMP_PATHWAY 0 0.03
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members Pathway Pathway_517 ST_GRANULE_CELL_SURVIVAL_PATHWAY 0 0.02
Category members GO Category GO:0051393 alpha-actinin binding Database 0
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_387 ST_T_CELL_SIGNAL_TRANSDUCTION 0 0
Category members Pathway Pathway_445 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 0 0
Category members Pathway Pathway_515 ST_B_CELL_ANTIGEN_RECEPTOR 0 0
Category members Pathway Pathway_516 ST_PAC1_RECEPTOR_PATHWAY 0 0
Category members Pathway Pathway_922 KEGG_ECM_RECEPTOR_INTERACTION 0 0
Category members GO Category GO:0002011 morphogenesis of an epithelial sheet Database 0
Category members GO Category GO:0002162 dystroglycan binding Database 0
Category members GO Category GO:0005604 basement membrane Database 0
Category members GO Category GO:0008307 structural constituent of muscle Database 0
Category members GO Category GO:0009279 cell outer membrane Database 0
Category members GO Category GO:0016340 calcium-dependent cell-matrix adhesion Database 0
Category members GO Category GO:0033268 node of Ranvier Database 0
Category members GO Category GO:0042169 SH2 domain binding Database 0
Category members GO Category GO:0043237 laminin-1 binding Database 0
Category members GO Category GO:0043434 response to peptide hormone Database 0
Category members GO Category GO:0051898 negative regulation of protein kinase B signaling Database 0
Category members GO Category GO:0060441 epithelial tube branching involved in lung morphogenesis Database 0
Category members GO Category GO:0060445 branching involved in salivary gland morphogenesis Database 0
Category members GO Category GO:0070938 contractile ring Database 0


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