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Query: HMOX1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HMOX1 0 -4.078 0.330 0.220 -1.817 -1.289

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HMOX1 Ubiquitylation K243 -0.972 _ASNK(gl)VQDSAPVETPR_
HMOX1 Ubiquitylation K256 -1.769 _GK(gl)PPLNTR_

Background Information for HMOX1:


Pubmed-HMOX1 »
Uniprot-HMOX1 »
Biogrid-HMOX1 »
ProteomicsDB-HMOX1 »

Tumorportal-HMOX1 »
COSMIC-HMOX1 »
GenomeRNAi-HMOX1 »
Genecards-HMOX1


Protein-protein Interactions for HMOX1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ADAM33 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD97 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDC20B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDX19B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR77 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HMOX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHAC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SRPRB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STIM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBC1D22B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HMOX1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Haem_Oase IPR002051 0
Category members Haem_Oase-like IPR016053 0
Category members Haem_Oase-like_multi-hlx IPR016084 0


Protein complexes (CORUM database) featuring HMOX1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring HMOX1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:24055347 Jungmichel et al., 2013 UV-stimulated poly(ADP-Ribosyl)ation targets Jungmichel et al., 2013 INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0043627 response to estrogen Database 0.4
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0043305 negative regulation of mast cell degranulation Database 0.26
Category members GO Category GO:0045765 regulation of angiogenesis Database 0.24
Category members GO Category GO:0048661 positive regulation of smooth muscle cell proliferation Database 0.24
Category members GO Category GO:0045766 positive regulation of angiogenesis Database 0.19
Category members GO Category GO:0042542 response to hydrogen peroxide Database 0.19
Category members GO Category GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity Database 0.18
Category members GO Category GO:0071276 cellular response to cadmium ion Database 0.13
Category members GO Category GO:0032764 negative regulation of mast cell cytokine production Database 0.13
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0008217 regulation of blood pressure Database 0.09
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members GO Category GO:0007588 excretion Database 0.08
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0034383 low-density lipoprotein particle clearance Database 0.07
Category members GO Category GO:0045080 positive regulation of chemokine biosynthetic process Database 0.06
Category members GO Category GO:0014806 smooth muscle hyperplasia Database 0.04
Category members GO Category GO:0020037 heme binding Database 0.04
Category members GO Category GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress Database 0.03
Category members GO Category GO:0051090 regulation of sequence-specific DNA binding transcription factor activity Database 0.02
Category members GO Category GO:0043392 negative regulation of DNA binding Database 0.01
Category members Pathway Pathway_81 KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM 0 0.01
Category members Pathway Pathway_193 REACTOME_IRON_UPTAKE_AND_TRANSPORT 0 0
Category members Pathway Pathway_440 PID_FRA_PATHWAY 0 0
Category members Pathway Pathway_749 BIOCARTA_IL10_PATHWAY 0 0
Category members Pathway Pathway_88 REACTOME_METABOLISM_OF_PORPHYRINS 0 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001935 endothelial cell proliferation Database 0
Category members GO Category GO:0002246 wound healing involved in inflammatory response Database 0
Category members GO Category GO:0002686 negative regulation of leukocyte migration Database 0
Category members GO Category GO:0004392 heme oxygenase (decyclizing) activity Database 0
Category members GO Category GO:0004630 phospholipase D activity Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005901 caveola Database 0
Category members GO Category GO:0006778 porphyrin-containing compound metabolic process Database 0
Category members GO Category GO:0006788 heme oxidation Database 0
Category members GO Category GO:0006879 cellular iron ion homeostasis Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0010656 negative regulation of muscle cell apoptotic process Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0031670 cellular response to nutrient Database 0
Category members GO Category GO:0034101 erythrocyte homeostasis Database 0
Category members GO Category GO:0035094 response to nicotine Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0042167 heme catabolic process Database 0
Category members GO Category GO:0042168 heme metabolic process Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0045909 positive regulation of vasodilation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048662 negative regulation of smooth muscle cell proliferation Database 0
Category members GO Category GO:0051260 protein homooligomerization Database 0
Category members GO Category GO:0055072 iron ion homeostasis Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0071243 cellular response to arsenic-containing substance Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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