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Query: MLH1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MLH1 0 2.196 -0.460 0.110 -0.360 1.227 1.219

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for MLH1:


Pubmed-MLH1 »
Uniprot-MLH1 »
Biogrid-MLH1 »
ProteomicsDB-MLH1 »

Tumorportal-MLH1 »
COSMIC-MLH1 »
GenomeRNAi-MLH1 »
Genecards-MLH1


Protein-protein Interactions for MLH1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FAN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MLH1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PMS2 Cat. description Hein, Mann, Cell 2015


Protein Domains in MLH1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HATPase_C IPR003594 1.07
Category members Ribosomal_S5_D2-typ_fold IPR020568 1.06
Category members DNA_mismatch_repair_fam IPR002099 0
Category members DNA_mismatch_repair_C IPR013507 0


Protein complexes (CORUM database) featuring MLH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 433 BASC complex (BRCA1-associated genome surveillance complex) Database 1.74
Category members Corum 434 BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) Database 0.83
Category members Corum 2817 BRCA1-BARD1-BACH1-DNA damage complex I Database 0.79
Category members Corum 376 PCNA-MutS-alpha-MutL-alpha-DNA complex Database 0.43
Category members Corum 244 BRAFT complex Database 0.29
Category members Corum 435 BASC (Ab 81) complex (BRCA1-associated genome surveillance complex) Database 0.23
Category members Corum 290 MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex Database 0.18
Category members Corum 369 MSH2-MSH6-PMS2-MLH1 complex Database 0.18
Category members Corum 370 MSH2-MSH6-PMS1-MLH1 complex Database 0.18
Category members Corum 431 MSH2-MSH6-PMS2-MLH1 complex Database 0.18
Category members Corum 424 EXO1-MLH1-PCNA complex Database 0.17
Category members Corum 246 BLM complex III Database 0.01
Category members Corum 285 PCNA-MLH1-PMS1 complex Database 0
Category members Corum 291 MSH2-MLH1-PMS2 DNA-repair initiation complex Database 0
Category members Corum 292 MutL-alpha complex Database 0
Category members Corum 379 MutL-alpha complex Database 0
Category members Corum 380 MutL-beta complex Database 0
Category members Corum 415 EXO1-MLH1-PMS2 complex Database 0
Category members Corum 423 EXO1-MLH1-PMS2 complex Database 0


Categories featuring MLH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members GO Category GO:0005694 chromosome Database 3.87
Category members Pathway Pathway_874 REACTOME_MEIOTIC_RECOMBINATION 0 3.7
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0000794 condensed nuclear chromosome Database 1.58
Category members GO Category GO:0000793 condensed chromosome Database 1.32
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members Pathway Pathway_341 KEGG_MISMATCH_REPAIR 0 1.02
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0006303 double-strand break repair via nonhomologous end joining Database 0.79
Category members Disease phenotype MUIR-TORRE_SYNDROME MUIR-TORRE SYNDROME Database 0.46
Category members GO Category GO:0032137 guanine/thymine mispair binding Database 0.46
Category members GO Category GO:0001673 male germ cell nucleus Database 0.44
Category members GO Category GO:0006298 mismatch repair Database 0.33
Category members GO Category GO:0030983 mismatched DNA binding Database 0.27
Category members GO Category GO:0000712 resolution of meiotic recombination intermediates Database 0.25
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members Disease phenotype ENDOMETRIAL_CANCER ENDOMETRIAL CANCER Database 0.21
Category members GO Category GO:0016447 somatic recombination of immunoglobulin gene segments Database 0.21
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members GO Category GO:0002204 somatic recombination of immunoglobulin genes involved in immune response Database 0.18
Category members Disease phenotype Constitutional_mismatch_repair_deficiency_syndrome Constitutional mismatch repair deficiency syndrome Database 0.18
Category members Disease phenotype MISMATCH_REPAIR_CANCER_SYNDROME MISMATCH REPAIR CANCER SYNDROME Database 0.18
Category members Disease phenotype Nonpolyposis_Turcot_syndrome Nonpolyposis Turcot syndrome Database 0.18
Category members Disease phenotype Hereditary_nonpolyposis_colon_cancer Hereditary nonpolyposis colon cancer Database 0.14
Category members GO Category GO:0007060 male meiosis chromosome segregation Database 0.11
Category members GO Category GO:0048477 oogenesis Database 0.11
Category members GO Category GO:0045190 isotype switching Database 0.11
Category members GO Category GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening Database 0.06
Category members GO Category GO:0045950 negative regulation of mitotic recombination Database 0.05
Category members GO Category GO:0045132 meiotic chromosome segregation Database 0.01
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members GO Category GO:0000795 synaptonemal complex Database 0
Category members GO Category GO:0007129 synapsis Database 0
Category members GO Category GO:0007131 reciprocal meiotic recombination Database 0
Category members GO Category GO:0007140 male meiosis Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0016446 somatic hypermutation of immunoglobulin genes Database 0
Category members GO Category GO:0032300 mismatch repair complex Database 0
Category members GO Category GO:0032389 MutLalpha complex Database 0
Category members GO Category GO:0032407 MutSalpha complex binding Database 0
Category members GO Category GO:0043566 structure-specific DNA binding Database 0


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