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Query: TBK1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TBK1 0 -0.689

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TBK1 Ubiquitylation K137 -0.689 _DIK(gl)PGNIMR_

Background Information for TBK1:


Pubmed-TBK1 »
Uniprot-TBK1 »
Biogrid-TBK1 »
ProteomicsDB-TBK1 »

Tumorportal-TBK1 »
COSMIC-TBK1 »
GenomeRNAi-TBK1 »
Genecards-TBK1


Protein-protein Interactions for TBK1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APBA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BBOX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CALCOCO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIF1AN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IKBKG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRAF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRAF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIM10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TXLNA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TXLNB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TBK1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring TBK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5212 Kinase maturation complex 2 Database 0.18
Category members Corum 5286 TNF-alpha/NF-kappa B signaling complex 10 Database 0.18


Categories featuring TBK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0032481 positive regulation of type I interferon production Database 0.54
Category members GO Category GO:0006954 inflammatory response Database 0.49
Category members GO Category GO:0051219 phosphoprotein binding Database 0.33
Category members GO Category GO:0035666 TRIF-dependent toll-like receptor signaling pathway Database 0.29
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0034138 toll-like receptor 3 signaling pathway Database 0.28
Category members GO Category GO:0034142 toll-like receptor 4 signaling pathway Database 0.27
Category members GO Category GO:0002756 MyD88-independent toll-like receptor signaling pathway Database 0.25
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members GO Category GO:0050830 defense response to Gram-positive bacterium Database 0.09
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members Pathway Pathway_484 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 0 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_1226 REACTOME_TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY 0 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0033138 positive regulation of peptidyl-serine phosphorylation Database 0.03
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1165 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION 0 0
Category members Pathway Pathway_354 KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 0 0
Category members Pathway Pathway_483 KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_612 KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_785 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING 0 0
Category members Pathway Pathway_825 REACTOME_ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON 0 0
Category members Disease phenotype Herpetic_encephalitis Herpetic encephalitis Database 0
Category members GO Category GO:0002218 activation of innate immune response Database 0
Category members GO Category GO:0007249 I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0010008 endosome membrane Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0032480 negative regulation of type I interferon production Database 0
Category members GO Category GO:0032727 positive regulation of interferon-alpha production Database 0
Category members GO Category GO:0032728 positive regulation of interferon-beta production Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0045359 positive regulation of interferon-beta biosynthetic process Database 0


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