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I-kappaB kinase/NF-kappaB signaling
(GO:0007249)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
RPS27A 4 -1.330 2.560 -0.309 0.131 -0.009
UBC 3 -0.309 0.131 -0.009
UBC 3
UBC 3
UBB 3 -0.309 0.131 -0.009
UBA52 3 -1.260 2.180 -0.309 0.131 -0.009
UBA52 3 -1.260 2.180
TAB3 2 -0.550 1.560 0.022 -0.207
TAB3 2 -0.550 1.560
TAB1 1 1.890 -0.670
TAB1 1 1.890 -0.670 1.657
RIPK2 1 -1.740 3.580
TANK 1 0.110 0.120
BCL10 1 0.000 0.200
TIFA 1 -1.510 2.530
SNIP1 1 1.160 -0.620
TAB2 0 -0.030 -0.580
IKBKG 0
HACD3 0 0.540 -0.250
HACD3 0 0.540 -0.250 0.188 0.116
IKBKB 0 0.400 0.610
MAP3K7 0 -1.120 1.140 -1.048
AZI2 0 0.690 -0.730
CHUK 0 -0.480
TICAM2 0 0.641 1.449

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
AZI2 Ubiquitylation K192 -0.015 _IELQK(gl)AK_
BCL10 Phosphorylation S138 1.515 1.393 _SNS(ph)DESNFSEK_
CHUK Ubiquitylation K296 -1.637 _GGPVDLTLK(gl)QPR_
HACD3 Ubiquitylation K122 0.325 _QVNITVQK(gl)K_
HACD3 Ubiquitylation K123 -0.603 0.819 _K(gl)VSQWWER_
HACD3 Phosphorylation S152 0.751 0.683 _WLDES(ph)DAEM(ox)ELR_
IKBKB Ubiquitylation K106 0.253 _K(gl)YLNQFENCCGLR_
IKBKB Phosphorylation S672 0.670 0.244 _GPVSGS(ph)PDSMNASR_
IKBKG Ubiquitylation K285 -1.202 -0.389 _QEVIDKLK(gl)EEAEQHK_
IKBKG Ubiquitylation K309 0.123 0.725 _AQADIYK(gl)ADFQAER_
IKBKG Ubiquitylation K344 0.060 _LK(gl)ASCQESAR_
IKBKG Phosphorylation S387 -1.270 -1.418 _S(ph)PPEEPPDFCCPK_
MAP3K7 Phosphorylation S374 0.149 -0.337 _GS(ph)SVESLPPTSEGK_
MAP3K7 Phosphorylation S375 0.171 -0.087 _GSS(ph)VESLPPTSEGK_
MAP3K7 Phosphorylation S389 1.072 1.445 _RMS(ph)ADMSEIEAR_
MAP3K7 Phosphorylation S439 0.246 0.198 _S(ph)IQDLTVTGTEPGQVSSR_
MAP3K7 Ubiquitylation K474 -0.385 -0.242 _MITTSGPTSEK(gl)PTR_
MAP3K7 Ubiquitylation K589 -0.104 _SLSTYYQQCK(gl)K_
MAP3K7 Ubiquitylation K590 -0.551 0.560 _K(gl)QLEVIR_
RIPK2 Ubiquitylation K410 -2.810 _AAFCDHK(gl)TTPCSSAIINPLSTAGNSER_
RIPK2 Phosphorylation S531 0.884 0.839 _SPS(ph)LNLLQNK_
RIPK2 Ubiquitylation K538 -2.659 _SPSLNLLQNK(gl)SM_
RPS27A Ubiquitylation K6 1.066 0.995 _MQIFVK(gl)TLTGK_
RPS27A Ubiquitylation K11 -0.488 -0.081 _TLTGK(gl)TITLEVEPSDTIENVKAK(gl)_
RPS27A Ubiquitylation K27 -0.882 -0.159 _TLTGK(gl)TITLEVEPSDTIENVK(gl)AK_
RPS27A Ubiquitylation K29 -1.087 -1.029 _AK(gl)IQDK(gl)EGIPPDQQR_
RPS27A Ubiquitylation K33 -0.736 -0.407 _IQDK(gl)EGIPPDQQR_
RPS27A Ubiquitylation K48 -0.062 0.315 _LIFAGK(gl)QLEDGRTLSDYNIQK_
RPS27A Phosphorylation S57 1.909 0.548 _TLS(ph)DYNIQK_
RPS27A Ubiquitylation K63 0.276 0.299 _TLSDYNIQK(gl)ESTLHLVLR_
RPS27A Ubiquitylation K99 0.109 2.111 _VK(gl)LAVLK_
RPS27A Ubiquitylation K104 0.674 2.102 _LAVLK(gl)YYK_
RPS27A Ubiquitylation K107 2.949 3.611 _YYK(gl)VDENGK(gl)ISR_
RPS27A Ubiquitylation K113 1.572 3.672 _YYK(gl)VDENGK(gl)ISR_
RPS27A Ubiquitylation K152 4.747 4.970 _CCLTYCFNK(gl)PEDK_
RPS27A Ubiquitylation K156 4.809 _CCLTYCFNKPEDK(gl)_
SNIP1 Phosphorylation S35 -0.473 -0.436 _QERLS(ph)PEVAPPAHR_
SNIP1 Phosphorylation S49 -0.946 _RPDHS(ph)GGSPSPPTSEPAR_
SNIP1 Phosphorylation S52 -1.157 -1.156 _RPDHSGGS(ph)PSPPTSEPAR_
SNIP1 Phosphorylation S153 0.008 0.248 _RTS(ph)NERPGSGQGQGR_
SNIP1 Phosphorylation S200 2.205 _NDVGGGGS(ph)ESQELVPRPGGNNK_
SNIP1 Phosphorylation S202 2.205 _NDVGGGGS(ph)ESQELVPRPGGNNK_
TAB1 Phosphorylation S7 -0.170 0.140 _S(ph)LLQSEQQPSWTDDLPLCHLSGVGSASNR_
TAB1 Phosphorylation S16 -0.138 0.069 _SLLQSEQQPS(ph)WTDDLPLCHLSGVGSASNR_
TAB1 Ubiquitylation K186 -1.015 _SYSADGK(gl)GTESHPPEDSWLK_
TAB1 Ubiquitylation K371 0.032 _LSQLGLDAGK(gl)IK_
TAB1 Ubiquitylation K373 -0.007 _LSQLGLDAGKIK(gl)_
TAB2 Phosphorylation S580 -0.075 _S(ph)NSISQIPSLEEMQQLR_
TAB2 Phosphorylation S582 0.331 _SNS(ph)ISQIPSLEEMQQLR_
TAB2 Ubiquitylation K653 -0.519 -0.200 _SIIK(gl)TPK_
TAB3 Phosphorylation S4 3.009 1.852 _(ac)AQS(ph)SPQLDIQVLHDLR_
TAB3 Phosphorylation S5 3.009 1.852 _(ac)AQS(ph)SPQLDIQVLHDLR_
TANK Ubiquitylation K195 -2.273 0.787 _QEALFK(gl)PQAK_
TANK Ubiquitylation K199 -1.047 _TDKQEALFKPQAK(gl)DDINR_
TANK Ubiquitylation K231 -0.635 1.969 _GLCRDEEDTSFESLSK(gl)FNVK_
TANK Ubiquitylation K308 -0.969 _TTDK(gl)TKPSNLVNTCIR_
TANK Ubiquitylation K310 -0.969 _TTDK(gl)TKPSNLVNTCIR_
TIFA Ubiquitylation K48 -0.386 _LPSSEVVK(gl)FGR_
TIFA Ubiquitylation K63 0.876 -0.239 _NSNICHYTFQDK(gl)QVSR_
UBA52 Ubiquitylation K6 1.066 0.995 _MQIFVK(gl)TLTGK_
UBA52 Ubiquitylation K11 -0.488 -0.081 _TLTGK(gl)TITLEVEPSDTIENVKAK(gl)_
UBA52 Ubiquitylation K27 -0.882 -0.159 _TLTGK(gl)TITLEVEPSDTIENVK(gl)AK_
UBA52 Ubiquitylation K29 -1.087 -1.029 _AK(gl)IQDK(gl)EGIPPDQQR_
UBA52 Ubiquitylation K33 -0.736 -0.407 _IQDK(gl)EGIPPDQQR_
UBA52 Ubiquitylation K48 -0.062 0.315 _LIFAGK(gl)QLEDGRTLSDYNIQK_
UBA52 Phosphorylation S57 1.909 0.548 _TLS(ph)DYNIQK_
UBA52 Ubiquitylation K63 0.276 0.299 _TLSDYNIQK(gl)ESTLHLVLR_
UBA52 Ubiquitylation K93 0.181 2.418 _YNCDK(gl)MICR_
UBA52 Ubiquitylation K99 0.109 2.111 _VK(gl)LAVLK_
UBA52 Ubiquitylation K104 0.674 2.102 _LAVLK(gl)YYK_
UBA52 Ubiquitylation K107 2.949 3.611 _YYK(gl)VDENGK(gl)ISR_
UBA52 Ubiquitylation K113 1.572 3.672 _YYK(gl)VDENGK(gl)ISR_
UBA52 Ubiquitylation K152 4.747 4.970 _CCLTYCFNK(gl)PEDK_
UBA52 Ubiquitylation K156 4.809 _CCLTYCFNKPEDK(gl)_
UBB Ubiquitylation K6 1.066 0.995 _MQIFVK(gl)TLTGK_
UBB Ubiquitylation K11 -0.488 -0.081 _TLTGK(gl)TITLEVEPSDTIENVKAK(gl)_
UBB Ubiquitylation K27 -0.882 -0.159 _TLTGK(gl)TITLEVEPSDTIENVK(gl)AK_
UBB Ubiquitylation K29 -1.087 -1.029 _AK(gl)IQDK(gl)EGIPPDQQR_
UBB Ubiquitylation K33 -0.736 -0.407 _IQDK(gl)EGIPPDQQR_
UBB Ubiquitylation K48 -0.062 0.315 _LIFAGK(gl)QLEDGRTLSDYNIQK_
UBB Phosphorylation S57 1.909 0.548 _TLS(ph)DYNIQK_
UBB Ubiquitylation K63 0.276 0.299 _TLSDYNIQK(gl)ESTLHLVLR_
UBB Ubiquitylation K99 0.109 2.111 _VK(gl)LAVLK_
UBB Ubiquitylation K104 0.674 2.102 _LAVLK(gl)YYK_
UBB Ubiquitylation K107 2.949 3.611 _YYK(gl)VDENGK(gl)ISR_
UBB Ubiquitylation K113 1.572 3.672 _YYK(gl)VDENGK(gl)ISR_
UBB Ubiquitylation K152 4.747 4.970 _CCLTYCFNK(gl)PEDK_
UBB Ubiquitylation K156 4.809 _CCLTYCFNKPEDK(gl)_
UBC Ubiquitylation K6 1.066 0.995 _MQIFVK(gl)TLTGK_
UBC Ubiquitylation K11 -0.488 -0.081 _TLTGK(gl)TITLEVEPSDTIENVKAK(gl)_
UBC Ubiquitylation K27 -0.882 -0.159 _TLTGK(gl)TITLEVEPSDTIENVK(gl)AK_
UBC Ubiquitylation K29 -1.087 -1.029 _AK(gl)IQDK(gl)EGIPPDQQR_
UBC Ubiquitylation K33 -0.736 -0.407 _IQDK(gl)EGIPPDQQR_
UBC Ubiquitylation K48 -0.062 0.315 _LIFAGK(gl)QLEDGRTLSDYNIQK_
UBC Ubiquitylation K48 -0.062 0.315 _LIFAGK(gl)QLEDGRTLSDYNIQK_
UBC Ubiquitylation K48 -0.062 0.315 _LIFAGK(gl)QLEDGRTLSDYNIQK_
UBC Phosphorylation S57 1.909 0.548 _TLS(ph)DYNIQK_
UBC Ubiquitylation K63 0.276 0.299 _TLSDYNIQK(gl)ESTLHLVLR_
UBC Ubiquitylation K99 0.109 2.111 _VK(gl)LAVLK_
UBC Ubiquitylation K104 0.674 2.102 _LAVLK(gl)YYK_
UBC Ubiquitylation K107 2.949 3.611 _YYK(gl)VDENGK(gl)ISR_
UBC Ubiquitylation K113 1.572 3.672 _YYK(gl)VDENGK(gl)ISR_
UBC Ubiquitylation K152 4.747 4.970 _CCLTYCFNK(gl)PEDK_
UBC Ubiquitylation K156 4.809 _CCLTYCFNKPEDK(gl)_


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