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Query: BCL10

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BCL10 1 3.108 0.000 0.200

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BCL10 Phosphorylation S138 1.515 1.393 _SNS(ph)DESNFSEK_

Background Information for BCL10:


Pubmed-BCL10 »
Uniprot-BCL10 »
Biogrid-BCL10 »
ProteomicsDB-BCL10 »

Tumorportal-BCL10 »
COSMIC-BCL10 »
GenomeRNAi-BCL10 »
Genecards-BCL10


Protein-protein Interactions for BCL10
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015


Protein Domains in BCL10
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DEATH-like_dom IPR011029 1.15
Category members CARD IPR001315 0.55


Protein complexes (CORUM database) featuring BCL10
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2053 BCL10-MALT1 complex Database 0
Category members Corum 2054 CASP8-FADD-MALT1-BCL10 complex Database 0
Category members Corum 2055 CASP8-CHUK-IKBKB-MALT1-BCL10 complex Database 0
Category members Corum 2056 BCL10-CHUK-BCL10-IKBKB complex Database 0
Category members Corum 2745 Ubiquitin ligase complex (TRAF6, TAB2, MALT1, UEV1A, BCL10) Database 0
Category members Corum 2752 CARMA1-BCL10-MALT1 complex Database 0
Category members Corum 2753 FYB-CARMA1-BCL-10-MALT1 complex Database 0


Categories featuring BCL10
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_706 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 0 1.96
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0043130 ubiquitin binding Database 1.22
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_804 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 0 0.86
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members Pathway Pathway_754 SA_PROGRAMMED_CELL_DEATH 0 0.61
Category members GO Category GO:0042327 positive regulation of phosphorylation Database 0.52
Category members GO Category GO:0019900 kinase binding Database 0.45
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Disease phenotype MESOTHELIOMA_MALIGNANT MESOTHELIOMA MALIGNANT Database 0.31
Category members GO Category GO:0019209 kinase activator activity Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0051059 NF-kappaB binding Database 0.25
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members GO Category GO:0001783 B cell apoptotic process Database 0.23
Category members Pathway Pathway_573 REACTOME_TCR_SIGNALING 0 0.2
Category members Pathway Pathway_648 KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.19
Category members Pathway Pathway_705 PID_CD8_TCR_PATHWAY 0 0.17
Category members GO Category GO:0050870 positive regulation of T cell activation Database 0.13
Category members GO Category GO:0043422 protein kinase B binding Database 0.12
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0050856 regulation of T cell receptor signaling pathway Database 0.11
Category members Pathway Pathway_687 PID_TCR_PATHWAY 0 0.08
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0043621 protein self-association Database 0.07
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0005881 cytoplasmic microtubule Database 0.04
Category members GO Category GO:0042226 interleukin-6 biosynthetic process Database 0.04
Category members GO Category GO:0009620 response to fungus Database 0.02
Category members Pathway Pathway_1051 PID_NFKAPPAB_CANONICAL_PATHWAY 0 0
Category members Pathway Pathway_540 PID_BCR_5PATHWAY 0 0
Category members Pathway Pathway_618 REACTOME_DOWNSTREAM_TCR_SIGNALING 0 0
Category members GO Category GO:0001772 immunological synapse Database 0
Category members GO Category GO:0001843 neural tube closure Database 0
Category members GO Category GO:0002020 protease binding Database 0
Category members GO Category GO:0002237 response to molecule of bacterial origin Database 0
Category members GO Category GO:0002250 adaptive immune response Database 0
Category members GO Category GO:0002906 negative regulation of mature B cell apoptotic process Database 0
Category members GO Category GO:0005764 lysosome Database 0
Category members GO Category GO:0006968 cellular defense response Database 0
Category members GO Category GO:0007249 I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0016064 immunoglobulin mediated immune response Database 0
Category members GO Category GO:0031398 positive regulation of protein ubiquitination Database 0
Category members GO Category GO:0032094 response to food Database 0
Category members GO Category GO:0032449 CBM complex Database 0
Category members GO Category GO:0032765 positive regulation of mast cell cytokine production Database 0
Category members GO Category GO:0042101 T cell receptor complex Database 0
Category members GO Category GO:0042109 lymphotoxin A biosynthetic process Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0045416 positive regulation of interleukin-8 biosynthetic process Database 0
Category members GO Category GO:0046696 lipopolysaccharide receptor complex Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0
Category members GO Category GO:0051259 protein oligomerization Database 0
Category members GO Category GO:0051260 protein homooligomerization Database 0
Category members GO Category GO:0070231 T cell apoptotic process Database 0
Category members GO Category GO:0071260 cellular response to mechanical stimulus Database 0


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