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bioLOGIC Data

Query: UBC

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
UBC	3	12.049
UBC	3	12.049			-0.309	0.131	-0.009

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
UBC	Ubiquitylation	K152	4.747	4.970	_CCLTYCFNK(gl)PEDK_
UBC	Ubiquitylation	K113	1.572	3.672	_YYK(gl)VDENGK(gl)ISR_
UBC	Ubiquitylation	K107	2.949	3.611	_YYK(gl)VDENGK(gl)ISR_
UBC	Ubiquitylation	K99	0.109	2.111	_VK(gl)LAVLK_
UBC	Ubiquitylation	K104	0.674	2.102	_LAVLK(gl)YYK_
UBC	Ubiquitylation	K6	1.066	0.995	_MQIFVK(gl)TLTGK_
UBC	Phosphorylation	S57	1.909	0.548	_TLS(ph)DYNIQK_
UBC	Ubiquitylation	K48	-0.062	0.315	_LIFAGK(gl)QLEDGRTLSDYNIQK_
UBC	Ubiquitylation	K48	-0.062	0.315	_LIFAGK(gl)QLEDGRTLSDYNIQK_
UBC	Ubiquitylation	K48	-0.062	0.315	_LIFAGK(gl)QLEDGRTLSDYNIQK_
UBC	Ubiquitylation	K63	0.276	0.299	_TLSDYNIQK(gl)ESTLHLVLR_
UBC	Ubiquitylation	K11	-0.488	-0.081	_TLTGK(gl)TITLEVEPSDTIENVKAK(gl)_
UBC	Ubiquitylation	K27	-0.882	-0.159	_TLTGK(gl)TITLEVEPSDTIENVK(gl)AK_
UBC	Ubiquitylation	K33	-0.736	-0.407	_IQDK(gl)EGIPPDQQR_
UBC	Ubiquitylation	K29	-1.087	-1.029	_AK(gl)IQDK(gl)EGIPPDQQR_
UBC	Ubiquitylation	K156	4.809		_CCLTYCFNKPEDK(gl)_

Background Information for UBC:

Pubmed-UBC »

Uniprot-UBC »

Biogrid-UBC »

ProteomicsDB-UBC »

Tumorportal-UBC »

COSMIC-UBC »

GenomeRNAi-UBC »

Genecards-UBC

Protein-protein Interactions for UBC

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait RHOT2	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in UBC

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	Rad60/SUMO_like	IPR022617	1.93
Category members	Ubiquitin-rel_dom	IPR029071	1.79
Category members	Ubiquitin-like	IPR000626	1.61
Category members	Ubiquitin	IPR019956	0.87

Protein complexes (CORUM database) featuring UBC

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)

Categories featuring UBC

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	DDR Literature	pubmedid:24332808	Marechal et al., 2014 RPA-mediated recruitment		INF
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005654	nucleoplasm	Database	INF
Category members	GO Category	GO:0005829	cytosol	Database	INF
Category members	GO Category	GO:0006281	DNA repair	Database	INF
Category members	GO Category	GO:0010467	gene expression	Database	INF
Category members	GO Category	GO:0016032	viral process	Database	INF
Category members	GO Category	GO:0016070	RNA metabolic process	Database	INF
Category members	GO Category	GO:0016071	mRNA metabolic process	Database	INF
Category members	GO Category	GO:0000278	mitotic cell cycle	Database	10.63
Category members	DDR Literature	pubmedid:19647519	Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation		3.6
Category members	GO Category	GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Database	3.38
Category members	GO Category	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Database	3.35
Category members	GO Category	GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Database	3.26
Category members	GO Category	GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Database	2.59
Category members	GO Category	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Database	2.5
Category members	GO Category	GO:0000209	protein polyubiquitination	Database	2.46
Category members	GO Category	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Database	2.46
Category members	GO Category	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	Database	2.21
Category members	GO Category	GO:0006915	apoptotic process	Database	2.12
Category members	GO Category	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Database	1.39
Category members	GO Category	GO:0000082	G1/S transition of mitotic cell cycle	Database	1.23
Category members	GO Category	GO:0005886	plasma membrane	Database	1.21
Category members	GO Category	GO:0006351	transcription, DNA-templated	Database	1.07
Category members	GO Category	GO:0042981	regulation of apoptotic process	Database	0.79
Category members	GO Category	GO:0008585	female gonad development	Database	0.64
Category members	GO Category	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Database	0.64
Category members	GO Category	GO:0048011	neurotrophin TRK receptor signaling pathway	Database	0.63
Category members	GO Category	GO:0021888	hypothalamus gonadotrophin-releasing hormone neuron development	Database	0.62
Category members	GO Category	GO:0043066	negative regulation of apoptotic process	Database	0.6
Category members	GO Category	GO:0032481	positive regulation of type I interferon production	Database	0.54
Category members	GO Category	GO:0019221	cytokine-mediated signaling pathway	Database	0.44
Category members	GO Category	GO:0016197	endosomal transport	Database	0.43
Category members	GO Category	GO:0038095	Fc-epsilon receptor signaling pathway	Database	0.36
Category members	GO Category	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	Database	0.32
Category members	GO Category	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Database	0.29
Category members	GO Category	GO:0008543	fibroblast growth factor receptor signaling pathway	Database	0.29
Category members	GO Category	GO:0034138	toll-like receptor 3 signaling pathway	Database	0.28
Category members	GO Category	GO:0010992	ubiquitin homeostasis	Database	0.28
Category members	GO Category	GO:0034142	toll-like receptor 4 signaling pathway	Database	0.27
Category members	GO Category	GO:0007173	epidermal growth factor receptor signaling pathway	Database	0.26
Category members	GO Category	GO:0043065	positive regulation of apoptotic process	Database	0.26
Category members	GO Category	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Database	0.25
Category members	GO Category	GO:0006367	transcription initiation from RNA polymerase II promoter	Database	0.25
Category members	GO Category	GO:0007179	transforming growth factor beta receptor signaling pathway	Database	0.25
Category members	GO Category	GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	Database	0.21
Category members	GO Category	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Database	0.13
Category members	GO Category	GO:0002224	toll-like receptor signaling pathway	Database	0.12
Category members	GO Category	GO:0055085	transmembrane transport	Database	0.12
Category members	GO Category	GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	Database	0.09
Category members	GO Category	GO:0030666	endocytic vesicle membrane	Database	0.08
Category members	GO Category	GO:0050852	T cell receptor signaling pathway	Database	0.06
Category members	GO Category	GO:0045087	innate immune response	Database	0.05
Category members	GO Category	GO:0007219	Notch signaling pathway	Database	0.05
Category members	GO Category	GO:0007144	female meiosis I	Database	0.04
Category members	GO Category	GO:0034146	toll-like receptor 5 signaling pathway	Database	0.04
Category members	GO Category	GO:0034166	toll-like receptor 10 signaling pathway	Database	0.04
Category members	GO Category	GO:0034162	toll-like receptor 9 signaling pathway	Database	0.04
Category members	GO Category	GO:0032479	regulation of type I interferon production	Database	0.04
Category members	GO Category	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Database	0.02
Category members	GO Category	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Database	0.02
Category members	GO Category	GO:0034134	toll-like receptor 2 signaling pathway	Database	0.01
Category members	Pathway	Pathway_43	KEGG_PPAR_SIGNALING_PATHWAY	0	0
Category members	GO Category	GO:0000187	activation of MAPK activity	Database	0
Category members	GO Category	GO:0002020	protease binding	Database	0
Category members	GO Category	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Database	0
Category members	GO Category	GO:0007141	male meiosis I	Database	0
Category members	GO Category	GO:0007220	Notch receptor processing	Database	0
Category members	GO Category	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Database	0
Category members	GO Category	GO:0007254	JNK cascade	Database	0
Category members	GO Category	GO:0010008	endosome membrane	Database	0
Category members	GO Category	GO:0019068	virion assembly	Database	0
Category members	GO Category	GO:0019082	viral protein processing	Database	0
Category members	GO Category	GO:0032480	negative regulation of type I interferon production	Database	0
Category members	GO Category	GO:0034220	ion transmembrane transport	Database	0
Category members	GO Category	GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	Database	0
Category members	GO Category	GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	Database	0
Category members	GO Category	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Database	0
Category members	GO Category	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Database	0
Category members	GO Category	GO:0051403	stress-activated MAPK cascade	Database	0
Category members	GO Category	GO:0060613	fat pad development	Database	0
Category members	GO Category	GO:0071456	cellular response to hypoxia	Database	0