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Query: UBB

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
UBB 3 12.049 -0.309 0.131 -0.009

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
UBB Ubiquitylation K152 4.747 4.970 _CCLTYCFNK(gl)PEDK_
UBB Ubiquitylation K113 1.572 3.672 _YYK(gl)VDENGK(gl)ISR_
UBB Ubiquitylation K107 2.949 3.611 _YYK(gl)VDENGK(gl)ISR_
UBB Ubiquitylation K99 0.109 2.111 _VK(gl)LAVLK_
UBB Ubiquitylation K104 0.674 2.102 _LAVLK(gl)YYK_
UBB Ubiquitylation K6 1.066 0.995 _MQIFVK(gl)TLTGK_
UBB Phosphorylation S57 1.909 0.548 _TLS(ph)DYNIQK_
UBB Ubiquitylation K48 -0.062 0.315 _LIFAGK(gl)QLEDGRTLSDYNIQK_
UBB Ubiquitylation K63 0.276 0.299 _TLSDYNIQK(gl)ESTLHLVLR_
UBB Ubiquitylation K11 -0.488 -0.081 _TLTGK(gl)TITLEVEPSDTIENVKAK(gl)_
UBB Ubiquitylation K27 -0.882 -0.159 _TLTGK(gl)TITLEVEPSDTIENVK(gl)AK_
UBB Ubiquitylation K33 -0.736 -0.407 _IQDK(gl)EGIPPDQQR_
UBB Ubiquitylation K29 -1.087 -1.029 _AK(gl)IQDK(gl)EGIPPDQQR_
UBB Ubiquitylation K156 4.809 _CCLTYCFNKPEDK(gl)_

Background Information for UBB:


Pubmed-UBB »
Uniprot-UBB »
Biogrid-UBB »
ProteomicsDB-UBB »

Tumorportal-UBB »
COSMIC-UBB »
GenomeRNAi-UBB »
Genecards-UBB


Protein-protein Interactions for UBB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AKAP13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AKT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP2S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APBB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APOL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARPC5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ASB9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATP6V0D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BTBD6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C16orf58 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C19orf39 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C22orf41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C5orf44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C7orf69 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CALCOCO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAV3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDH19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CIB4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CNPPD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COMMD8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COPS7B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPA6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRYBA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CSNK1G3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CUTA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CXorf59 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CYP7B1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DFFB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DHX57 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNAJB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EID1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF2B2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ENSA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FADS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM188A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM58A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM73B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM8A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FANCG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXL16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXL21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXO6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FNTB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FUZ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLT1D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GRTP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HRSP12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IKBKG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL1F5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL20RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INPP5K Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INTU Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KCNS3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LIMK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LITAF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LTBR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGOH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYO1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NICN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NR1I3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NR2C2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OSTalpha Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PANK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDGFRB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PFDN4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPARD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPTC7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRKACG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRMT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRPS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB30 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAPGEF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RASL10B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHEB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF126 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF19B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RTDR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SKP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC13A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC17A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC45A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPANXA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPINK7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TGM5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMCO6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFAIP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF10A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPTE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRAF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIM11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBE2D2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBE2E3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBL7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait USP48 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UXT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VPS36 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VWA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VWA5A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR83 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WSB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YAF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFAND2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in UBB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Rad60/SUMO_like IPR022617 1.93
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members Ubiquitin-like IPR000626 1.61
Category members Ubiquitin IPR019956 0.87


Protein complexes (CORUM database) featuring UBB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring UBB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.38
Category members GO Category GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.35
Category members GO Category GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.26
Category members GO Category GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Database 2.59
Category members GO Category GO:0002474 antigen processing and presentation of peptide antigen via MHC class I Database 2.5
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members GO Category GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Database 2.46
Category members GO Category GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I Database 2.21
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Database 1.39
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0008585 female gonad development Database 0.64
Category members GO Category GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway Database 0.64
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0021888 hypothalamus gonadotrophin-releasing hormone neuron development Database 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0032481 positive regulation of type I interferon production Database 0.54
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members GO Category GO:0016197 endosomal transport Database 0.43
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members GO Category GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia Database 0.32
Category members GO Category GO:0035666 TRIF-dependent toll-like receptor signaling pathway Database 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0034138 toll-like receptor 3 signaling pathway Database 0.28
Category members GO Category GO:0010992 ubiquitin homeostasis Database 0.28
Category members GO Category GO:0034142 toll-like receptor 4 signaling pathway Database 0.27
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0002756 MyD88-independent toll-like receptor signaling pathway Database 0.25
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Database 0.21
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members GO Category GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway Database 0.09
Category members GO Category GO:0030666 endocytic vesicle membrane Database 0.08
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0007144 female meiosis I Database 0.04
Category members GO Category GO:0034146 toll-like receptor 5 signaling pathway Database 0.04
Category members GO Category GO:0034166 toll-like receptor 10 signaling pathway Database 0.04
Category members GO Category GO:0034162 toll-like receptor 9 signaling pathway Database 0.04
Category members GO Category GO:0032479 regulation of type I interferon production Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members GO Category GO:0034134 toll-like receptor 2 signaling pathway Database 0.01
Category members Pathway Pathway_31 KEGG_PARKINSONS_DISEASE 0 0
Category members GO Category GO:0000187 activation of MAPK activity Database 0
Category members GO Category GO:0002755 MyD88-dependent toll-like receptor signaling pathway Database 0
Category members GO Category GO:0007141 male meiosis I Database 0
Category members GO Category GO:0007220 Notch receptor processing Database 0
Category members GO Category GO:0007249 I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0007254 JNK cascade Database 0
Category members GO Category GO:0010008 endosome membrane Database 0
Category members GO Category GO:0019068 virion assembly Database 0
Category members GO Category GO:0019082 viral protein processing Database 0
Category members GO Category GO:0032480 negative regulation of type I interferon production Database 0
Category members GO Category GO:0034220 ion transmembrane transport Database 0
Category members GO Category GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway Database 0
Category members GO Category GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0
Category members GO Category GO:0051403 stress-activated MAPK cascade Database 0
Category members GO Category GO:0060613 fat pad development Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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