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Query: IKBKG

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
IKBKG 0 -1.840

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
IKBKG Ubiquitylation K309 0.123 0.725 _AQADIYK(gl)ADFQAER_
IKBKG Ubiquitylation K344 0.060 _LK(gl)ASCQESAR_
IKBKG Ubiquitylation K285 -1.202 -0.389 _QEVIDKLK(gl)EEAEQHK_
IKBKG Phosphorylation S387 -1.270 -1.418 _S(ph)PPEEPPDFCCPK_

Background Information for IKBKG:


Pubmed-IKBKG »
Uniprot-IKBKG »
Biogrid-IKBKG »
ProteomicsDB-IKBKG »

Tumorportal-IKBKG »
COSMIC-IKBKG »
GenomeRNAi-IKBKG »
Genecards-IKBKG


Protein-protein Interactions for IKBKG
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDC37 Cat. description Hein, Mann, Cell 2015
Category members IP bait IKBKG Cat. description Hein, Mann, Cell 2015
Category members IP bait NFKBIA Cat. description Hein, Mann, Cell 2015
Category members IP bait ARNTL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM196A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INHA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LTBR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAP3K14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYNC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in IKBKG
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring IKBKG
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5266 TNF-alpha/NF-kappa B signaling complex 6 Database 3.74
Category members Corum 5233 TNF-alpha/NF-kappa B signaling complex 5 Database 0.29
Category members Corum 5829 IKBKG-CHUK complex Database 0.18
Category members Corum 5286 TNF-alpha/NF-kappa B signaling complex 10 Database 0.18
Category members Corum 2727 SRC-3 complex Database 0.1
Category members Corum 4043 NEMO-HIF2(alpha)-ARNT complex Database 0.1
Category members Corum 5232 TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) Database 0.09
Category members Corum 5193 TNF-alpha/NF-kappa B signaling complex (CHUK, KPNA3, NFKB2, NFKBIB, REL, IKBKG, NFKB1, NFKBIE, RELB, NFKBIA, RELA, TNIP2) Database 0.03
Category members Corum 2118 CHUK-ERC1-IKBKB-IKBKG Database 0
Category members Corum 2121 CHUK-IKBKB-IKBKG complex Database 0
Category members Corum 5194 TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) Database 0
Category members Corum 5230 CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex Database 0
Category members Corum 5828 IKBKG-IKBKB complex Database 0
Category members Corum 5844 I-kappa-B kinase (IKK) complex Database 0


Categories featuring IKBKG
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_706 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 0 1.96
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0006955 immune response Database 1.22
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_608 SIG_CD40PATHWAYMAP 0 0.89
Category members Pathway Pathway_804 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 0 0.86
Category members Pathway Pathway_1043 REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 0 0.78
Category members GO Category GO:0032481 positive regulation of type I interferon production Database 0.54
Category members GO Category GO:0006954 inflammatory response Database 0.49
Category members Pathway Pathway_542 BIOCARTA_AKT_PATHWAY 0 0.45
Category members Pathway Pathway_975 REACTOME_IL1_SIGNALING 0 0.42
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0035666 TRIF-dependent toll-like receptor signaling pathway Database 0.29
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0034138 toll-like receptor 3 signaling pathway Database 0.28
Category members GO Category GO:0034142 toll-like receptor 4 signaling pathway Database 0.27
Category members GO Category GO:0002756 MyD88-independent toll-like receptor signaling pathway Database 0.25
Category members Pathway Pathway_1053 KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_188 KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 0 0.24
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members GO Category GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Database 0.21
Category members Pathway Pathway_573 REACTOME_TCR_SIGNALING 0 0.2
Category members Pathway Pathway_648 KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.19
Category members Pathway Pathway_596 PID_TRAIL_PATHWAY 0 0.17
Category members Pathway Pathway_705 PID_CD8_TCR_PATHWAY 0 0.17
Category members GO Category GO:0007250 activation of NF-kappaB-inducing kinase activity Database 0.17
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members Pathway Pathway_514 ST_GAQ_PATHWAY 0 0.17
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0008385 IkappaB kinase complex Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_797 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 0 0.12
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members GO Category GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway Database 0.09
Category members Pathway Pathway_687 PID_TCR_PATHWAY 0 0.08
Category members Pathway Pathway_484 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 0 0.06
Category members Pathway Pathway_953 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI 0 0.06
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members Pathway Pathway_814 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_996 REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 0 0.05
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members Pathway Pathway_1056 REACTOME_NOD1_2_SIGNALING_PATHWAY 0 0.04
Category members Pathway Pathway_834 REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 0 0.04
Category members GO Category GO:0034146 toll-like receptor 5 signaling pathway Database 0.04
Category members GO Category GO:0034166 toll-like receptor 10 signaling pathway Database 0.04
Category members Pathway Pathway_1052 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX 0 0.04
Category members GO Category GO:0034162 toll-like receptor 9 signaling pathway Database 0.04
Category members GO Category GO:0001782 B cell homeostasis Database 0.02
Category members GO Category GO:0034134 toll-like receptor 2 signaling pathway Database 0.01
Category members Pathway Pathway_1047 BIOCARTA_RELA_PATHWAY 0 0.01
Category members Pathway Pathway_1021 ST_TUMOR_NECROSIS_FACTOR_PATHWAY 0 0
Category members Pathway Pathway_1025 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 0 0
Category members Pathway Pathway_1042 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 0 0
Category members Pathway Pathway_1045 BIOCARTA_TNFR2_PATHWAY 0 0
Category members Pathway Pathway_1046 BIOCARTA_STRESS_PATHWAY 0 0
Category members Pathway Pathway_1051 PID_NFKAPPAB_CANONICAL_PATHWAY 0 0
Category members Pathway Pathway_1055 BIOCARTA_CD40_PATHWAY 0 0
Category members Pathway Pathway_1057 BIOCARTA_NFKB_PATHWAY 0 0
Category members Pathway Pathway_1120 REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION 0 0
Category members Pathway Pathway_1121 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 0 0
Category members Pathway Pathway_207 KEGG_PRIMARY_IMMUNODEFICIENCY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_354 KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 0 0
Category members Pathway Pathway_40 KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_483 KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_500 PID_FCER1_PATHWAY 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_540 PID_BCR_5PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_589 BIOCARTA_RACCYCD_PATHWAY 0 0
Category members Pathway Pathway_606 KEGG_ACUTE_MYELOID_LEUKEMIA 0 0
Category members Pathway Pathway_612 KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_618 REACTOME_DOWNSTREAM_TCR_SIGNALING 0 0
Category members Pathway Pathway_631 PID_IL1_PATHWAY 0 0
Category members Pathway Pathway_650 PID_FAS_PATHWAY 0 0
Category members Pathway Pathway_658 ST_GA13_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members Pathway Pathway_850 PID_TOLL_ENDOGENOUS_PATHWAY 0 0
Category members Pathway Pathway_937 BIOCARTA_TOLL_PATHWAY 0 0
Category members Pathway Pathway_954 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION 0 0
Category members Pathway Pathway_958 REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX 0 0
Category members GO Category GO:0000187 activation of MAPK activity Database 0
Category members GO Category GO:0002755 MyD88-dependent toll-like receptor signaling pathway Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0007249 I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0007254 JNK cascade Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway Database 0
Category members GO Category GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0
Category members GO Category GO:0051403 stress-activated MAPK cascade Database 0


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