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Query: IKBKB

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
IKBKB 0 1.777 0.400 0.610

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
IKBKB Phosphorylation S672 0.670 0.244 _GPVSGS(ph)PDSMNASR_
IKBKB Ubiquitylation K106 0.253 _K(gl)YLNQFENCCGLR_

Background Information for IKBKB:


Pubmed-IKBKB »
Uniprot-IKBKB »
Biogrid-IKBKB »
ProteomicsDB-IKBKB »

Tumorportal-IKBKB »
COSMIC-IKBKB »
GenomeRNAi-IKBKB »
Genecards-IKBKB


Protein-protein Interactions for IKBKB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDC37 Cat. description Hein, Mann, Cell 2015
Category members IP bait IKBKG Cat. description Hein, Mann, Cell 2015
Category members IP bait IKBKB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IKBKG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAP3K14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in IKBKB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ubiquitin-rel_dom IPR029071 1.79
Category members Ubiquitin-like IPR000626 1.61
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members LipoPS_kinase IPR010440 0
Category members Tyr_kinase_cat_dom IPR020635 0
Category members IKKbetaNEMObind IPR022007 0


Protein complexes (CORUM database) featuring IKBKB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5266 TNF-alpha/NF-kappa B signaling complex 6 Database 3.74
Category members Corum 5234 IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex Database 0.57
Category members Corum 5233 TNF-alpha/NF-kappa B signaling complex 5 Database 0.29
Category members Corum 2727 SRC-3 complex Database 0.1
Category members Corum 2055 CASP8-CHUK-IKBKB-MALT1-BCL10 complex Database 0
Category members Corum 2056 BCL10-CHUK-BCL10-IKBKB complex Database 0
Category members Corum 2100 CHUK-IKBKB-MAP3K14 complex Database 0
Category members Corum 2101 IKKA-IKKB complex Database 0
Category members Corum 2105 IkappaB kinase complex (IKBKB, CHUK, IKBKAP, NFKBIA, RELA, MAP3K14) Database 0
Category members Corum 2118 CHUK-ERC1-IKBKB-IKBKG Database 0
Category members Corum 2121 CHUK-IKBKB-IKBKG complex Database 0
Category members Corum 5194 TNF-alpha/NF-kappa B signaling complex (SEC16A, CHUK, IKBKB, NFKB2, REL, IKBKG, MAP3K14, RELA, FBXW7, USP2) Database 0
Category members Corum 5828 IKBKG-IKBKB complex Database 0
Category members Corum 5844 I-kappa-B kinase (IKK) complex Database 0


Categories featuring IKBKB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members Pathway Pathway_706 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 0 1.96
Category members Pathway Pathway_118 PID_FOXO_PATHWAY 0 0.97
Category members Pathway Pathway_804 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 0 0.86
Category members Pathway Pathway_1043 REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 0 0.78
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0032481 positive regulation of type I interferon production Database 0.54
Category members Pathway Pathway_208 PID_TAP63_PATHWAY 0 0.52
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0006954 inflammatory response Database 0.49
Category members Pathway Pathway_542 BIOCARTA_AKT_PATHWAY 0 0.45
Category members Pathway Pathway_975 REACTOME_IL1_SIGNALING 0 0.42
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members GO Category GO:0035666 TRIF-dependent toll-like receptor signaling pathway Database 0.29
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0034138 toll-like receptor 3 signaling pathway Database 0.28
Category members GO Category GO:0034142 toll-like receptor 4 signaling pathway Database 0.27
Category members GO Category GO:0002756 MyD88-independent toll-like receptor signaling pathway Database 0.25
Category members Pathway Pathway_1053 KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_188 KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION 0 0.24
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members GO Category GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Database 0.21
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members Pathway Pathway_573 REACTOME_TCR_SIGNALING 0 0.2
Category members Pathway Pathway_648 KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.19
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_596 PID_TRAIL_PATHWAY 0 0.17
Category members Pathway Pathway_705 PID_CD8_TCR_PATHWAY 0 0.17
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0008385 IkappaB kinase complex Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_797 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 0 0.12
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members GO Category GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway Database 0.09
Category members Pathway Pathway_687 PID_TCR_PATHWAY 0 0.08
Category members Pathway Pathway_484 REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 0 0.06
Category members Pathway Pathway_953 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI 0 0.06
Category members GO Category GO:0050852 T cell receptor signaling pathway Database 0.06
Category members Pathway Pathway_814 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members Pathway Pathway_1056 REACTOME_NOD1_2_SIGNALING_PATHWAY 0 0.04
Category members Pathway Pathway_834 REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 0 0.04
Category members GO Category GO:0034146 toll-like receptor 5 signaling pathway Database 0.04
Category members GO Category GO:0034166 toll-like receptor 10 signaling pathway Database 0.04
Category members Pathway Pathway_1052 REACTOME_IRAK1_RECRUITS_IKK_COMPLEX 0 0.04
Category members GO Category GO:0034162 toll-like receptor 9 signaling pathway Database 0.04
Category members GO Category GO:0071356 cellular response to tumor necrosis factor Database 0.03
Category members GO Category GO:0001782 B cell homeostasis Database 0.02
Category members GO Category GO:0034134 toll-like receptor 2 signaling pathway Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1047 BIOCARTA_RELA_PATHWAY 0 0.01
Category members Pathway Pathway_1000 BIOCARTA_MAPK_PATHWAY 0 0
Category members Pathway Pathway_1025 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 0 0
Category members Pathway Pathway_1042 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 0 0
Category members Pathway Pathway_1044 BIOCARTA_NTHI_PATHWAY 0 0
Category members Pathway Pathway_1045 BIOCARTA_TNFR2_PATHWAY 0 0
Category members Pathway Pathway_1046 BIOCARTA_STRESS_PATHWAY 0 0
Category members Pathway Pathway_1048 BIOCARTA_KERATINOCYTE_PATHWAY 0 0
Category members Pathway Pathway_1051 PID_NFKAPPAB_CANONICAL_PATHWAY 0 0
Category members Pathway Pathway_1054 BIOCARTA_IL1R_PATHWAY 0 0
Category members Pathway Pathway_1055 BIOCARTA_CD40_PATHWAY 0 0
Category members Pathway Pathway_1057 BIOCARTA_NFKB_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_354 KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 0 0
Category members Pathway Pathway_40 KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_483 KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_500 PID_FCER1_PATHWAY 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_540 PID_BCR_5PATHWAY 0 0
Category members Pathway Pathway_569 PID_GMCSF_PATHWAY 0 0
Category members Pathway Pathway_572 KEGG_APOPTOSIS 0 0
Category members Pathway Pathway_589 BIOCARTA_RACCYCD_PATHWAY 0 0
Category members Pathway Pathway_606 KEGG_ACUTE_MYELOID_LEUKEMIA 0 0
Category members Pathway Pathway_610 PID_NFKAPPAB_ATYPICAL_PATHWAY 0 0
Category members Pathway Pathway_612 KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_618 REACTOME_DOWNSTREAM_TCR_SIGNALING 0 0
Category members Pathway Pathway_631 PID_IL1_PATHWAY 0 0
Category members Pathway Pathway_650 PID_FAS_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members Pathway Pathway_786 REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES 0 0
Category members Pathway Pathway_803 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL 0 0
Category members Pathway Pathway_806 REACTOME_P75NTR_SIGNALS_VIA_NFKB 0 0
Category members Pathway Pathway_850 PID_TOLL_ENDOGENOUS_PATHWAY 0 0
Category members Pathway Pathway_882 BIOCARTA_TID_PATHWAY 0 0
Category members Pathway Pathway_902 BIOCARTA_41BB_PATHWAY 0 0
Category members Pathway Pathway_937 BIOCARTA_TOLL_PATHWAY 0 0
Category members Pathway Pathway_954 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION 0 0
Category members Pathway Pathway_958 REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX 0 0
Category members Pathway Pathway_97 KEGG_TYPE_II_DIABETES_MELLITUS 0 0
Category members GO Category GO:0002755 MyD88-dependent toll-like receptor signaling pathway Database 0
Category members GO Category GO:0007249 I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0007252 I-kappaB phosphorylation Database 0
Category members GO Category GO:0008384 IkappaB kinase activity Database 0
Category members GO Category GO:0009103 lipopolysaccharide biosynthetic process Database 0
Category members GO Category GO:0009615 response to virus Database 0
Category members GO Category GO:0009898 cytoplasmic side of plasma membrane Database 0
Category members GO Category GO:0010765 positive regulation of sodium ion transport Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0016773 phosphotransferase activity, alcohol group as acceptor Database 0
Category members GO Category GO:0035631 CD40 receptor complex Database 0
Category members GO Category GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway Database 0
Category members GO Category GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0


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