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Query: MSH6

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MSH6 2 6.291 -0.410 0.140 -0.115 0.232 0.645 0.407 0.101

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MSH6 Phosphorylation S830 0.130 1.666 _IHNVGS(ph)PLK_
MSH6 Ubiquitylation K1291 0.633 _FIK(gl)GACPK_
MSH6 Phosphorylation S137 0.203 0.359 _VHVQFFDDS(ph)PTR_
MSH6 Ubiquitylation K334 0.193 _QATSISSETK(gl)NTLR_
MSH6 Ubiquitylation K519 2.264 0.186 _IITK(gl)GTQTYSVLEGDPSENYSK_
MSH6 Ubiquitylation K476 1.536 0.184 _YSDSLVQK(gl)GYK_
MSH6 Ubiquitylation K852 -0.044 _AIMYEETTYSK(gl)K_
MSH6 Ubiquitylation K853 -0.044 _AIMYEETTYSK(gl)K_
MSH6 Ubiquitylation K1030 0.394 -0.156 _DVSLK(gl)DCMR_
MSH6 Ubiquitylation K1325 -0.190 _EFEK(gl)MNQSLR_
MSH6 Phosphorylation S227 -0.199 -0.192 _SEEDNEIES(ph)EEEVQPK_
MSH6 Phosphorylation S43 0.319 -0.234 _AAAAPGASPS(ph)PGGDAAWSEAGPGPR_
MSH6 Ubiquitylation K728 0.082 -0.280 _SGAIFTK(gl)AYQR_
MSH6 Ubiquitylation K896 -0.342 _QVISLQTK(gl)NPEGR_
MSH6 Ubiquitylation K1240 -0.672 _ELAETIK(gl)CR_
MSH6 Ubiquitylation K1009 -0.817 _YWTK(gl)TIEK_
MSH6 Ubiquitylation K997 -0.863 _NLPEEYELK(gl)STK_
MSH6 Phosphorylation S41 -0.708 -0.948 _AAAAPGAS(ph)PSPGGDAAWSEAGPGPRPLAR_
MSH6 Ubiquitylation K771 -0.582 -1.069 _VDTCHTPFGK(gl)R_
MSH6 Ubiquitylation K1296 -1.142 _GACPK(gl)SYGFNAAR_
MSH6 Ubiquitylation K1315 -1.738 _LANLPEEVIQK(gl)GHR_
MSH6 Phosphorylation T139 0.209 _VHVQFFDDSPT(ph)R_

Background Information for MSH6:


Pubmed-MSH6 »
Uniprot-MSH6 »
Biogrid-MSH6 »
ProteomicsDB-MSH6 »

Tumorportal-MSH6 »
COSMIC-MSH6 »
GenomeRNAi-MSH6 »
Genecards-MSH6


Protein-protein Interactions for MSH6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3I Cat. description Hein, Mann, Cell 2015
Category members IP bait MSH6 Cat. description Hein, Mann, Cell 2015


Protein Domains in MSH6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members PWWP_dom IPR000313 0.63
Category members DNA_mismatch_repair_MutS-lik_N IPR007695 0.43
Category members DNA_mmatch_repair_MutS_con_dom IPR007860 0.43
Category members DNA_mismatch_repair_MutS_N IPR016151 0.17
Category members DNA_mismatch_repair_MutS_C IPR000432 0.16
Category members DNA_mismatch_repair_MutS_core IPR007696 0.16
Category members DNA_mismatch_repair_MutS_clamp IPR007861 0.16


Protein complexes (CORUM database) featuring MSH6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 433 BASC complex (BRCA1-associated genome surveillance complex) Database 1.74
Category members Corum 286 PCNA-MSH2-MSH6 complex Database 0.88
Category members Corum 289 PCNA-MSH2-MSH6 complex Database 0.88
Category members Corum 377 PCNA-MutS-alpha-DNA initial complex Database 0.88
Category members Corum 436 BASC (Ab C-20) complex (BRCA1-associated genome surveillance complex) Database 0.88
Category members Corum 434 BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) Database 0.83
Category members Corum 2817 BRCA1-BARD1-BACH1-DNA damage complex I Database 0.79
Category members Corum 376 PCNA-MutS-alpha-MutL-alpha-DNA complex Database 0.43
Category members Corum 1078 MSH2-MSH6 complex Database 0.35
Category members Corum 2740 MutS-alpha complex Database 0.35
Category members Corum 374 MSH2-MSH6 complex Database 0.35
Category members Corum 369 MSH2-MSH6-PMS2-MLH1 complex Database 0.18
Category members Corum 370 MSH2-MSH6-PMS1-MLH1 complex Database 0.18
Category members Corum 431 MSH2-MSH6-PMS2-MLH1 complex Database 0.18
Category members Corum 2226 MutS-alpha-PK-zeta complex Database 0.13
Category members Corum 438 GCN5-TRRAP histone acetyltransferase complex Database 0.05
Category members Corum 2224 MSH2/6-BLM-p53-RAD51 complex Database 0


Categories featuring MSH6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members DDR Literature pubmedid:24055347 Jungmichel et al., 2013 UV-stimulated poly(ADP-Ribosyl)ation targets Jungmichel et al., 2013 INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members GO Category GO:0008094 DNA-dependent ATPase activity Database 2.31
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0032405 MutLalpha complex binding Database 1.47
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members Pathway Pathway_341 KEGG_MISMATCH_REPAIR 0 1.02
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0000228 nuclear chromosome Database 0.89
Category members GO Category GO:0009411 response to UV Database 0.79
Category members GO Category GO:0051096 positive regulation of helicase activity Database 0.73
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0000710 meiotic mismatch repair Database 0.54
Category members GO Category GO:0035064 methylated histone residue binding Database 0.53
Category members Disease phenotype MUIR-TORRE_SYNDROME MUIR-TORRE SYNDROME Database 0.46
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members GO Category GO:0032137 guanine/thymine mispair binding Database 0.46
Category members GO Category GO:0032142 single guanine insertion binding Database 0.43
Category members GO Category GO:0032357 oxidized purine DNA binding Database 0.43
Category members GO Category GO:0032143 single thymine insertion binding Database 0.35
Category members GO Category GO:0032301 MutSalpha complex Database 0.35
Category members GO Category GO:0006298 mismatch repair Database 0.33
Category members GO Category GO:0045910 negative regulation of DNA recombination Database 0.31
Category members GO Category GO:0030983 mismatched DNA binding Database 0.27
Category members GO Category GO:0043531 ADP binding Database 0.27
Category members Disease phenotype ENDOMETRIAL_CANCER ENDOMETRIAL CANCER Database 0.21
Category members GO Category GO:0016447 somatic recombination of immunoglobulin gene segments Database 0.21
Category members GO Category GO:0000400 four-way junction DNA binding Database 0.2
Category members Disease phenotype Constitutional_mismatch_repair_deficiency_syndrome Constitutional mismatch repair deficiency syndrome Database 0.18
Category members Disease phenotype MISMATCH_REPAIR_CANCER_SYNDROME MISMATCH REPAIR CANCER SYNDROME Database 0.18
Category members Disease phenotype Nonpolyposis_Turcot_syndrome Nonpolyposis Turcot syndrome Database 0.18
Category members Disease phenotype Hereditary_nonpolyposis_colon_cancer Hereditary nonpolyposis colon cancer Database 0.14
Category members GO Category GO:0045190 isotype switching Database 0.11
Category members GO Category GO:0008340 determination of adult lifespan Database 0.05
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0007131 reciprocal meiotic recombination Database 0
Category members GO Category GO:0016446 somatic hypermutation of immunoglobulin genes Database 0


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