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Query: MCL1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MCL1 0 -3.753 1.740 -0.780 -0.419

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MCL1 Ubiquitylation K308 -0.687 0.011 _DWLVK(gl)QR_
MCL1 Ubiquitylation K194 -1.646 -1.025 _EQATGAK(gl)DTK(gl)PMGR_
MCL1 Phosphorylation T163 -1.997 -1.027 _RPAVLPLLELVGESGNNTSTDGSLPST(ph)PPPAEEEEDELYR_
MCL1 Ubiquitylation K197 -1.782 -1.165 _EQATGAK(gl)DTK(gl)PMGR_
MCL1 Ubiquitylation K40 -0.321 _LLATEK(gl)EASAR_

Background Information for MCL1:


Pubmed-MCL1 »
Uniprot-MCL1 »
Biogrid-MCL1 »
ProteomicsDB-MCL1 »

Tumorportal-MCL1 »
COSMIC-MCL1 »
GenomeRNAi-MCL1 »
Genecards-MCL1


Protein-protein Interactions for MCL1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCL2L11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EDEM2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EDNRA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR77 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MCL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RANBP6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MCL1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Blc2_fam IPR026298 0.14
Category members Bcl2-like IPR002475 0.05


Protein complexes (CORUM database) featuring MCL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5823 MCL1-BAK1 complex Database 0


Categories featuring MCL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0008637 apoptotic mitochondrial changes Database 0.01
Category members Pathway Pathway_652 PID_IL6_7_PATHWAY 0 0
Category members GO Category GO:0001709 cell fate determination Database 0
Category members GO Category GO:0019725 cellular homeostasis Database 0
Category members GO Category GO:0034097 response to cytokine Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0051434 BH3 domain binding Database 0


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