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Query: SFN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SFN 0 -9.839 0.890 0.120 -4.300

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SFN Ubiquitylation K11 0.561 0.388 _AK(gl)LAEQAER_
SFN Ubiquitylation K49 -0.093 0.337 _NLLSVAYK(gl)_

Background Information for SFN:


Pubmed-SFN »
Uniprot-SFN »
Biogrid-SFN »
ProteomicsDB-SFN »

Tumorportal-SFN »
COSMIC-SFN »
GenomeRNAi-SFN »
Genecards-SFN


Protein-protein Interactions for SFN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HERC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAP3K2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA0930 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SFN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMTNL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SFN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members 14/03/2003 IPR000308 1.96
Category members 14-3-3_domain IPR023410 1.96


Protein complexes (CORUM database) featuring SFN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SFN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members DDR Literature pubmedid:24055347 Jungmichel et al., 2013 UV-stimulated poly(ADP-Ribosyl)ation targets Jungmichel et al., 2013 INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members Pathway Pathway_934 PID_PI3KCI_AKT_PATHWAY 0 2.5
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members Pathway Pathway_636 PID_PI3K_PLC_TRK_PATHWAY 0 1.85
Category members Pathway Pathway_455 PID_INSULIN_GLUCOSE_PATHWAY 0 1.7
Category members Pathway Pathway_1023 PID_NFAT_3PATHWAY 0 1.46
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members Pathway Pathway_118 PID_FOXO_PATHWAY 0 0.97
Category members Pathway Pathway_509 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 0 0.62
Category members GO Category GO:0030659 cytoplasmic vesicle membrane Database 0.62
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members Pathway Pathway_444 PID_P38_MK2_PATHWAY 0 0.42
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0051219 phosphoprotein binding Database 0.33
Category members Pathway Pathway_408 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 0 0.32
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0001836 release of cytochrome c from mitochondria Database 0.18
Category members Pathway Pathway_165 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0 0.18
Category members GO Category GO:0008426 protein kinase C inhibitor activity Database 0.15
Category members GO Category GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity Database 0.13
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Pathway Pathway_626 PID_A6B1_A6B4_INTEGRIN_PATHWAY 0 0.09
Category members GO Category GO:0046827 positive regulation of protein export from nucleus Database 0.03
Category members GO Category GO:0043616 keratinocyte proliferation Database 0.01
Category members Pathway Pathway_176 KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 0 0
Category members Pathway Pathway_209 PID_DELTA_NP63_PATHWAY 0 0
Category members GO Category GO:0006469 negative regulation of protein kinase activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0030216 keratinocyte differentiation Database 0
Category members GO Category GO:0030307 positive regulation of cell growth Database 0
Category members GO Category GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0043588 skin development Database 0


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